MX9709503A - Inhibicion bacteriana con un compuesto de oligosacarido. - Google Patents
Inhibicion bacteriana con un compuesto de oligosacarido.Info
- Publication number
- MX9709503A MX9709503A MX9709503A MX9709503A MX9709503A MX 9709503 A MX9709503 A MX 9709503A MX 9709503 A MX9709503 A MX 9709503A MX 9709503 A MX9709503 A MX 9709503A MX 9709503 A MX9709503 A MX 9709503A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- cation
- beta
- sialic acid
- so3b
- Prior art date
Links
- -1 oligosaccharide compound Chemical class 0.000 title abstract 3
- 230000001580 bacterial effect Effects 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 229920001542 oligosaccharide Polymers 0.000 title 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 abstract 3
- 150000001768 cations Chemical class 0.000 abstract 3
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 241001453380 Burkholderia Species 0.000 abstract 1
- 241000589513 Burkholderia cepacia Species 0.000 abstract 1
- 241000606768 Haemophilus influenzae Species 0.000 abstract 1
- 241000606766 Haemophilus parainfluenzae Species 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 206010057190 Respiratory tract infections Diseases 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invencion se refiere a un método para el tratamiento de infecciones respiratorias provocadas por una bacteria seleccionada dentro del grupo que consiste de S. pneumoniae, H. influenza, H. parinfluenzae, Burkholderia (Pseudomonas cepacia) y una mezcla de las mismas, mediante la administracion de una cantidad inhibitoria efectiva del compuesto de la formula (I), donde R1 es H, (beta-1)GalNAc-, SO3B (donde B es H o un cation) o un ácido siálico de la formula (II), donde R6, R7, R8 y R10 son cada uno independientemente H, acilo C1-C6, lactilo, alquilo C1-C6, sulfato, fosfato, anhidro, un ácido siálico de formula (II), (alfa-1)Fuc, (beta-1)Glc o bien (beta-1)Gal; R9 es NH-acilo C1-C6, glicolilamido, amino o hidrocilo; y A es H o bien un cation; R2 es H o bien (alfa-1)Fuc-; R3 y R4 son cada uno independientemente OH o bien NHAc; R5 es H, SO3B (donde B es H o un cation) o bien un ácido siálico de la formula (II) de conformidad con lo arriba definido; e Y es un enlace químico o bien un grupo de enlace; Z es H o bien un soporte multivalente; m es 0 o bien 1; y p es un numero entero de 1 a 1000; y una composicion farmacéutica que lo contiene.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/488,053 US5736533A (en) | 1995-06-07 | 1995-06-07 | Bacterial inhibition with an oligosaccharide compound |
| US08488053 | 1995-06-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9709503A true MX9709503A (es) | 1998-10-31 |
| MXPA97009503A MXPA97009503A (es) | 1999-01-11 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| EP0839042A1 (en) | 1998-05-06 |
| WO1996040169A1 (en) | 1996-12-19 |
| KR19990022658A (ko) | 1999-03-25 |
| AU5886596A (en) | 1996-12-30 |
| CA2224102A1 (en) | 1996-12-19 |
| NZ308961A (en) | 1999-10-28 |
| CN1192687A (zh) | 1998-09-09 |
| HUP9901150A2 (hu) | 1999-08-30 |
| EP0839042A4 (en) | 1999-04-07 |
| US6001819A (en) | 1999-12-14 |
| JPH11507043A (ja) | 1999-06-22 |
| IL122406A0 (en) | 1998-06-15 |
| US5736533A (en) | 1998-04-07 |
| HUP9901150A3 (en) | 2001-11-28 |
| AU710078B2 (en) | 1999-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69425671D1 (de) | Glucosamin-disaccharide, verfahren zu deren herstellung, pharmazeutische präparate davon und ihre verwendung | |
| MY109669A (en) | N,o-sulphated heparosans, process for, preparing them and pharmaceutical compositions containing them | |
| MX9604020A (es) | Arilalquildiazinonas. | |
| BR9714287A (pt) | Antibiótico cristalino designado solvato 6-o-metileritromicina forma 0, solvato de 6-o-metileritromicina forma 0, composição, processos para tratamento de infecções bacterianas em um mamìfero hospedeiro com necessidade de tal tratamento e para preparação de solvato de 6-o-metileritomicina a forma 0, 6-o-metileritromicina forma 0--etanolato, suspensão para administração oral, e, complexo de solvato de 6-o-metileritromicina a forma 0-carbÈmero. | |
| CA2419801A1 (en) | Steroid derived antibiotics | |
| DE69432627D1 (en) | Polymergebundene camptothecin-derivate | |
| MY122353A (en) | 13-membered azalides and their use as antibiotic agents | |
| DK0544592T3 (da) | N,O-sulfaterede heparosaner med høj molekylvægt, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger inde | |
| BG105543A (en) | Novel macrolide antibiotics | |
| IL71239A (en) | Pharmaceutical composition containing oligosaccharide derivatives for treatment or prophylaxis of pneumococcus infections | |
| NL300231I2 (nl) | Polyribosylribitolfosfaat omvattende entstofsamenstelling tegen haemophilus influenza type b en werkwijze voor de bereiding ervan. | |
| JPS57106695A (en) | Anthracycline g lycoside compound | |
| HUT70480A (en) | Mono and bis alkylamino-anthracyclines pharmaceutical compns. contg. them and process to prepare the said compds. | |
| TW268015B (es) | ||
| DE3172152D1 (en) | Anthracycline glycosides, intermediate compounds, process for preparing both and pharmaceutical compositions | |
| MY113874A (en) | Zwitterionic forms of trovafloxacin | |
| ATE199706T1 (de) | Vitamin d analoga und verfahren zu ihrer herstellung | |
| MY109729A (en) | Benzofuranylimidazole derivatives, a process for the preparation and therapeutical compositions containing the same | |
| UA48982C2 (uk) | Поліморфи проліків тровафлоксацину, спосіб їх отримання, спосіб лікування бактеріальної інфекції і фармацевтична композиція | |
| IE880737L (en) | 6-oxoprostaglandin-E derivatives. Method for their¹manufacture and their use as pharmaceuticals | |
| WO1983004263A1 (en) | Glucuronides and methods for their preparation | |
| ZA968280B (en) | Disubstituted piperidine derivatives | |
| AU1601483A (en) | Glucuronides and methods for their preparation | |
| JPS55162795A (en) | Novel aminoglycoside and its preparation | |
| JPS58188894A (ja) | ３−デメトキシフオルチマイシン類 |