MX9701363A - Compuestos de 1, 4-dihidropiridina. - Google Patents
Compuestos de 1, 4-dihidropiridina.Info
- Publication number
- MX9701363A MX9701363A MX9701363A MX9701363A MX9701363A MX 9701363 A MX9701363 A MX 9701363A MX 9701363 A MX9701363 A MX 9701363A MX 9701363 A MX9701363 A MX 9701363A MX 9701363 A MX9701363 A MX 9701363A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- alkyl
- unsubstituted
- heterocyclic
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Un compuesto de formula (I) y sus sales farmacéuticamente aceptables, en la cual A1 y A2 son cada uno de ellos halos; X es un enlace directo, CH2, CO, O, S, S(O)2; R1 se selecciona entre una diversidad de grupos tales como hidrogeno; alquilo C1-4 sustituido o sin sustituir; piperidinilo sustituido o sin sustituir; cicloalquilo, bicicloalquilo o tricicloaquilo C5-14 sustituido o sin sustituir , azaciclo-azabiciclo- o azatriciclo-, biciclo-alquenilo C7-10; benzociclo-alquilo C5-7; y un grupo heterocíclico, R2 es hidrogeno, alquilo C1-4, fenilo sustituido o sin sustituir y un grupo heterocíclico; y R3 y R4 son cada uno alquilo C1-5. Los nuevos compuestos de dihidropiridina de esta invencion tiene una excelente actividad antagonistas de bradicinina y por tanto son utiles para el tratamiento de inflamacion, enfermedad cardiovascular, dolor, resfriado comun, alergias, asma, pancreatitis, quemaduras, infeccion por virus, herida craneal, trauma multiple o similares en mamíferos, especialmente seres humanos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP1994/001398 WO1996006083A1 (en) | 1994-08-24 | 1994-08-24 | 2-(piperazinyl-1-carbonylmethyl)-1,4-dihydropyridines as bradykinin antagonists |
PCT/IB1995/000400 WO1996006082A1 (en) | 1994-08-24 | 1995-05-26 | Dihydropyridine derivatives as bradykinin antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9701363A true MX9701363A (es) | 1997-05-31 |
Family
ID=14098614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9701363A MX9701363A (es) | 1994-08-24 | 1995-05-26 | Compuestos de 1, 4-dihidropiridina. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5859011A (es) |
EP (1) | EP0777653B1 (es) |
JP (1) | JP3001978B2 (es) |
KR (1) | KR100235285B1 (es) |
CN (1) | CN1087737C (es) |
AT (1) | ATE204567T1 (es) |
AU (1) | AU689587B2 (es) |
CA (1) | CA2198231C (es) |
DE (1) | DE69522332T2 (es) |
DK (1) | DK0777653T3 (es) |
ES (1) | ES2159637T3 (es) |
FI (1) | FI970745A (es) |
GR (1) | GR3036907T3 (es) |
IL (1) | IL114968A (es) |
MX (1) | MX9701363A (es) |
MY (1) | MY115372A (es) |
NO (1) | NO970806L (es) |
NZ (1) | NZ285155A (es) |
TW (1) | TW500722B (es) |
WO (2) | WO1996006083A1 (es) |
ZA (1) | ZA977057B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TNSN97037A1 (fr) * | 1996-02-19 | 2005-03-15 | Pfizer | Derives de 1,4 -dihydropyridine, procede pour leur preparation et compositions pharmaceutiques les contenant. |
MX9701245A (es) * | 1996-02-19 | 1998-04-30 | Pfizer | Compuestos de 1,4 dihidropiridina. |
JP3823388B2 (ja) * | 1996-09-04 | 2006-09-20 | カシオ計算機株式会社 | 印刷装置 |
JPH11106375A (ja) * | 1997-08-18 | 1999-04-20 | Pfizer Pharmaceut Inc | ブラジキニンアンタゴニストとしての光学的に活性な1,4−ジヒドロピリジン化合物 |
KR100579792B1 (ko) | 1998-05-13 | 2006-05-12 | 동화약품공업주식회사 | 신규 2,5-피리딘디카복실산 유도체 |
DE60007603T2 (de) * | 1999-12-10 | 2004-06-24 | Pfizer Inc. | 5-Ring Heteroarylsubstituierte 1,4-Dihydropyridine als Bradykinin Antagonisten |
EP1110962A1 (en) * | 1999-12-10 | 2001-06-27 | Pfizer Inc. | Process for preparing 1,4-dihydropyridine compounds |
ES2191598T3 (es) * | 1999-12-10 | 2003-09-16 | Pfizer | Compuestos de 1,4-dihidropiridina sustituidos como antagonistas de bradiquinina. |
US6653313B2 (en) * | 2000-08-10 | 2003-11-25 | Warner-Lambert Company Llc | 1,4-dihydropyridine compounds as bradykinin antagonists |
DK2813502T3 (en) | 2013-06-14 | 2017-02-27 | Dompé Farm S P A | Bradykinin receptor antagonists and pharmaceutical compositions containing them |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5162497A (en) * | 1987-09-24 | 1992-11-10 | The Administrators Of The Tulane Educational Fund | Bradykinin analogs with non-peptide bond |
US5120750A (en) * | 1989-01-17 | 1992-06-09 | Synphar Laboratories, Inc. | Generation of 1,4-dihydropyridine derivatives |
US5610142A (en) * | 1992-10-08 | 1997-03-11 | Scios Inc. | Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids |
-
1994
- 1994-08-24 WO PCT/JP1994/001398 patent/WO1996006083A1/en unknown
-
1995
- 1995-05-26 US US08/793,561 patent/US5859011A/en not_active Expired - Fee Related
- 1995-05-26 EP EP95918113A patent/EP0777653B1/en not_active Expired - Lifetime
- 1995-05-26 JP JP8507896A patent/JP3001978B2/ja not_active Expired - Fee Related
- 1995-05-26 CN CN95194758A patent/CN1087737C/zh not_active Expired - Fee Related
- 1995-05-26 KR KR1019970701151A patent/KR100235285B1/ko not_active Application Discontinuation
- 1995-05-26 AT AT95918113T patent/ATE204567T1/de not_active IP Right Cessation
- 1995-05-26 DE DE69522332T patent/DE69522332T2/de not_active Expired - Fee Related
- 1995-05-26 WO PCT/IB1995/000400 patent/WO1996006082A1/en active IP Right Grant
- 1995-05-26 MX MX9701363A patent/MX9701363A/es not_active IP Right Cessation
- 1995-05-26 ES ES95918113T patent/ES2159637T3/es not_active Expired - Lifetime
- 1995-05-26 CA CA002198231A patent/CA2198231C/en not_active Expired - Fee Related
- 1995-05-26 AU AU24166/95A patent/AU689587B2/en not_active Ceased
- 1995-05-26 DK DK95918113T patent/DK0777653T3/da active
- 1995-07-11 TW TW084107170A patent/TW500722B/zh not_active IP Right Cessation
- 1995-08-17 IL IL11496895A patent/IL114968A/xx not_active IP Right Cessation
- 1995-08-22 MY MYPI95002477A patent/MY115372A/en unknown
- 1995-08-23 ZA ZA9707057A patent/ZA977057B/xx unknown
-
1997
- 1997-02-21 NO NO970806A patent/NO970806L/no not_active Application Discontinuation
- 1997-02-21 FI FI970745A patent/FI970745A/fi not_active Application Discontinuation
- 1997-02-24 NZ NZ285155A patent/NZ285155A/en unknown
-
2001
- 2001-10-16 GR GR20010401777T patent/GR3036907T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2198231A1 (en) | 1996-02-29 |
DE69522332D1 (de) | 2001-09-27 |
NO970806L (no) | 1997-04-21 |
AU2416695A (en) | 1996-03-14 |
MY115372A (en) | 2003-05-31 |
WO1996006082A1 (en) | 1996-02-29 |
DE69522332T2 (de) | 2002-01-03 |
WO1996006083A1 (en) | 1996-02-29 |
KR100235285B1 (ko) | 2000-02-01 |
GR3036907T3 (en) | 2002-01-31 |
ZA977057B (en) | 1997-02-24 |
IL114968A (en) | 1999-08-17 |
TW500722B (en) | 2002-09-01 |
JPH09510992A (ja) | 1997-11-04 |
DK0777653T3 (da) | 2001-10-08 |
CN1156449A (zh) | 1997-08-06 |
EP0777653B1 (en) | 2001-08-22 |
US5859011A (en) | 1999-01-12 |
NZ285155A (en) | 1998-06-26 |
CN1087737C (zh) | 2002-07-17 |
FI970745A0 (fi) | 1997-02-21 |
NO970806D0 (no) | 1997-02-21 |
CA2198231C (en) | 1999-12-07 |
FI970745A (fi) | 1997-02-21 |
EP0777653A1 (en) | 1997-06-11 |
AU689587B2 (en) | 1998-04-02 |
JP3001978B2 (ja) | 2000-01-24 |
KR970705555A (ko) | 1997-10-09 |
ES2159637T3 (es) | 2001-10-16 |
IL114968A0 (en) | 1995-12-08 |
ATE204567T1 (de) | 2001-09-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO913750L (no) | Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske derivater. | |
NZ325449A (en) | Naphthyl-substituted benzimidazole derivatives as anticoagulants | |
DE69433744D1 (de) | 3-amino-5-carboxy-substituierte piperidine und 3-amino-4-carboxy-substituierte pyrrolidine als tachykinin-antagonisten | |
TW330202B (en) | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | |
ATE293617T1 (de) | Oxybenzamidderivate als faktor-xa-inhibitoren | |
CA2360360A1 (en) | Piperidyl benzamide compounds, composition containing same and their use thereof | |
DE69012840D1 (de) | Adenosin-Derivate, die eine Aktivität gegen Bluthochdruck haben. | |
MX9701363A (es) | Compuestos de 1, 4-dihidropiridina. | |
FR2712591B1 (fr) | Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique. | |
NZ333513A (en) | 1,4-di-substituted piperidines and medicaments useful as muscarinic antagonists | |
NO934718L (no) | Nye HIV protease inhibitorer | |
UA85502C2 (en) | Diazaindole-dicarbonyl-piperazinyl antiviral agents | |
DK26289D0 (da) | Anvendelse af 1,4-disubstitueret piperidinyl til fremstilling af et farmaceutisk praeparat til behandling af insomnia | |
ATE259376T1 (de) | Heterozyklische verbindungen, ihre zwischenprodukte und elastase-inhibitoren | |
NO172893C (no) | Analogifremgangsmaate for fremstilling av nye terapeutisk aktive cefem-forbindelser | |
WO1999062893A3 (de) | Neue neurokininantagonisten, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen | |
CA2278057A1 (en) | Tachykinin antagonists | |
DE69522118T2 (de) | Thiazolidonon- oder oxazolidinonderivate zur behandlung von angina pectoris und zusammensetzungen die diese als wirkstoffe enthält | |
MX9701245A (es) | Compuestos de 1,4 dihidropiridina. | |
WO2003018564A1 (fr) | Inhibiteur d'acat selectif de la paroi vasculaire | |
CA2245857A1 (en) | 1,4-dihydropyridine compounds as bradykinin antagonists | |
ATE126190T1 (de) | 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-5- | |
SE9902596D0 (sv) | Pharmaceutically active compounds | |
DE69722630D1 (de) | Therapeutisches mittel zur behandlung von nierenerkrankungen | |
IT1232160B (it) | 2-(n-acil)ammino-6,7-dimetossi tetraline, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' antiipertensiva che le contengono |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
MM | Annulment or lapse due to non-payment of fees |