MX9700446A - Antagonistas de la hormona paratiroide (pth) y de los peptidos relacionados con la hormona paratiroide (pthrp). - Google Patents

Antagonistas de la hormona paratiroide (pth) y de los peptidos relacionados con la hormona paratiroide (pthrp).

Info

Publication number
MX9700446A
MX9700446A MX9700446A MX9700446A MX9700446A MX 9700446 A MX9700446 A MX 9700446A MX 9700446 A MX9700446 A MX 9700446A MX 9700446 A MX9700446 A MX 9700446A MX 9700446 A MX9700446 A MX 9700446A
Authority
MX
Mexico
Prior art keywords
pth
amino acid
pthrp
tryptophane
aromatic
Prior art date
Application number
MX9700446A
Other languages
English (en)
Other versions
MXPA97000446A (es
Inventor
Francois Cardinaux
Jean Honore M Feyen
Rainer Gamse
Frank Otto Gombert
Original Assignee
Novartis Ag Quien Tambien Usa
Social Bajo Las Versiones De N
Rtis Sa Y Novartis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9415255A external-priority patent/GB9415255D0/en
Priority claimed from GB9415254A external-priority patent/GB9415254D0/en
Application filed by Novartis Ag Quien Tambien Usa, Social Bajo Las Versiones De N, Rtis Sa Y Novartis Inc filed Critical Novartis Ag Quien Tambien Usa
Publication of MX9700446A publication Critical patent/MX9700446A/es
Publication of MXPA97000446A publication Critical patent/MXPA97000446A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion se refiere a compuestos PTH o PTHrP que tienen una potente actividad antagonica al receptor de PTH/PTHrP en el cual por lo menos uno de los residuos de aminoácidos que se presentan naturalmente en las posiciones 2 y 10, está reemplazado por triptofano u otro residuo de aminoácido que lleva un grupo aromático o un heteroaromático en su cadena lateral y, opcionalmente por lo menos uno de los residuos de aminoácidos que se presentan naturalmente en las posiciones 3 y 6 está reemplazado además por triptofano o por otro residuo de aminoácido que lleva grupo aromático o un grupo heteroaromático en su cadena lateral, tienen actividad farmacologica, por ejemplo, para la prevencion de condiciones que están asociadas con el incremento de calcio en el plasma causado por una liberacion excesiva de PTH o PTHrP.
MXPA/A/1997/000446A 1994-07-28 1997-01-16 Antagonistas de la hormona paratiroide (pth) y delos peptidos relacionados con la hormona paratiroide (pthrp) MXPA97000446A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9415255A GB9415255D0 (en) 1994-07-28 1994-07-28 Organic compounds
GB9415254A GB9415254D0 (en) 1994-07-28 1994-07-28 Organic compounds
GB9415254.3 1994-07-28
GB9415255.0 1994-07-28

Publications (2)

Publication Number Publication Date
MX9700446A true MX9700446A (es) 1998-06-28
MXPA97000446A MXPA97000446A (es) 1998-10-30

Family

ID=

Also Published As

Publication number Publication date
PL318017A1 (en) 1997-05-12
NO970356L (no) 1997-01-28
BR9508433A (pt) 1998-07-14
HUT77979A (hu) 1999-01-28
TR199500915A2 (tr) 1996-06-21
FI970168A0 (fi) 1997-01-15
FI970168A (fi) 1997-01-15
AU3167095A (en) 1996-02-22
CO4410206A1 (es) 1997-01-09
JPH10502091A (ja) 1998-02-24
WO1996003437A1 (en) 1996-02-08
SK12097A3 (en) 1997-08-06
EP0773958A1 (en) 1997-05-21
CZ23397A3 (en) 1997-07-16
IL114736A0 (en) 1995-11-27
NO970356D0 (no) 1997-01-28
CA2192787A1 (en) 1996-02-08

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