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Application filed by Smithkline Beechman PlcfiledCriticalSmithkline Beechman Plc
Priority claimed from PCT/EP1995/001757external-prioritypatent/WO1995031456A1/en
Publication of MXPA96005632ApublicationCriticalpatent/MXPA96005632A/en
Publication of MX9605632ApublicationCriticalpatent/MX9605632A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R1 represents (a) in which r represents an integer of 2 to 4, s represents 1 or 2 and t represents 0 or 1; R2 is a group OR4, where R4 is C1-4alkyl, C2-4alkenyl or C2-4alkynyl or a group OCOR5 where R5 is hydrogen or R4; and R3 is CN; said process comprising reacting a compound of formula (II) wherein R1' is R1 or a group convertible thereto, and R3' is an electron withdrawing group, with a source of nitrous acid, and thereafter converting the resulting =NOH group to =NR2 wherein R2 is as defined in formula (I), converting R1' and R3' when other than R1 and R3 to R1 and R3, and thereafter optionally forming a pharmaceutically acceptable salt.
MX9605632A1995-05-091995-05-09Process for the preparation of azabicyclic derivatives.
MX9605632A
(en)
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