MX9605550A - Metodo para detectar priones en una muestra, y animal transgenico utilizado para lo mismo. - Google Patents
Metodo para detectar priones en una muestra, y animal transgenico utilizado para lo mismo.Info
- Publication number
- MX9605550A MX9605550A MX9605550A MX9605550A MX9605550A MX 9605550 A MX9605550 A MX 9605550A MX 9605550 A MX9605550 A MX 9605550A MX 9605550 A MX9605550 A MX 9605550A MX 9605550 A MX9605550 A MX 9605550A
- Authority
- MX
- Mexico
- Prior art keywords
- transgenic animal
- sample
- same
- animal used
- detecting prions
- Prior art date
Links
- 230000009261 transgenic effect Effects 0.000 title abstract 3
- 102000029797 Prion Human genes 0.000 title abstract 2
- 108091000054 Prion Proteins 0.000 title abstract 2
- 102100025818 Major prion protein Human genes 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 108700026220 vif Genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0337—Animal models for infectious diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0337—Animal models for infectious diseases
- A01K2267/0343—Animal model for prion disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
La invencion incluye un gen de PrP artificial, un animal transgénico que contiene al gen, y un ensayo en donde el animal transgénico se utiliza para detectar la presencia de priones patogénicos en una muestra, o para diagnosticar una causa de muerte.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/242,188 US5565186A (en) | 1994-05-13 | 1994-05-13 | Method of detecting prions in a sample and transgenic animal used for same |
US08242188 | 1994-05-13 | ||
PCT/US1995/004426 WO1995031466A1 (en) | 1994-05-13 | 1995-04-10 | Method of detecting prions in a sample and transgenic animal used for same |
Publications (2)
Publication Number | Publication Date |
---|---|
MX9605550A true MX9605550A (es) | 1998-05-31 |
MXPA96005550A MXPA96005550A (es) | 1998-10-23 |
Family
ID=
Also Published As
Publication number | Publication date |
---|---|
CA2190160A1 (en) | 1995-11-23 |
WO1995031466A1 (en) | 1995-11-23 |
JPH10503925A (ja) | 1998-04-14 |
NZ284278A (en) | 1998-09-24 |
EP0759028A4 (en) | 1999-11-24 |
AU691277B2 (en) | 1998-05-14 |
US5565186A (en) | 1996-10-15 |
AU2284195A (en) | 1995-12-05 |
BR9507894A (pt) | 1997-09-23 |
DE759028T1 (de) | 2001-10-25 |
US5763740A (en) | 1998-06-09 |
EP0759028A1 (en) | 1997-02-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0759028A4 (en) | METHOD FOR DETECTING PRIONS IN A SAMPLE AND TRANSGENIC ANIMAL USED TO PERFORM THIS DETECTION | |
ATE114051T1 (de) | Verfahren zum nachweis von endotoxin. | |
EP0605003A3 (en) | Test procedure for the detection of the presence of bacteria. | |
MY103811A (en) | Detection of chemicals by immunoassay | |
DE69227379D1 (de) | Verfahren und Reagenzien zur Bestimmung von Bakterien in der zerebrospinalen Flüssigkeit | |
DE69422687D1 (de) | Biosensor zur hämatokritbestimmung | |
ATE234469T1 (de) | Verfahren zur erfassung des status eines organismus durch messung von peptiden | |
DE69737513D1 (de) | Teilchenförmiges markierungsmittel verwendendes analytassay | |
DE3875325D1 (de) | Vorrichtung zur messung von druckunterschieden waehrend des bohrens. | |
DK0943097T3 (da) | Fremgangsmåde til at påvise IgE | |
ES2157220T3 (es) | Aparato de ensayo analitico con control negativo y positivo incorporado. | |
DE69005069D1 (de) | Vorrichtung zur Feststellung des Vorhandenseins von fremden Stoffen. | |
DE69903831D1 (de) | Trenn- und nachweisverfahren für spermatozoide | |
DE69009922D1 (de) | Vorrichtung zur magnetischen Defekterkennung für Stahlbänder. | |
ES2184260T3 (es) | Sistema de ensayo que utiliza particulas magneticas. | |
MX9800894A (es) | Deteccion de priones en una muestra y preparacion de priones y animal transgenico utilizado para la misma. | |
AU2841695A (en) | A method for detecting disturbances of the protein C/protein S system | |
AU4663997A (en) | Detection and identification of non-polio enteroviruses | |
DE69628847D1 (de) | Testverfahren und testsatz zur diagnose von autoimmunerkrankungen | |
ES2112898T3 (es) | Metodo de ensayo. | |
DE3780604D1 (de) | Vorrichtung zur auswertung eines sauerstoffuehlers. | |
DE59000468D1 (de) | Verfahren zur schnellen pruefung der wirksamkeit von agenzien auf mikroorganismen. | |
AU3457101A (en) | Method for the evaluation of implantable materials | |
DE68917387D1 (de) | Dioxetane zur verwendung bei immuntests. | |
EP0445626A3 (en) | Functional test for determining protein s activity |