MX9603890A - Transgenic production of oligosaccharides and glycoconjugates. - Google Patents

Transgenic production of oligosaccharides and glycoconjugates.

Info

Publication number
MX9603890A
MX9603890A MX9603890A MX9603890A MX9603890A MX 9603890 A MX9603890 A MX 9603890A MX 9603890 A MX9603890 A MX 9603890A MX 9603890 A MX9603890 A MX 9603890A MX 9603890 A MX9603890 A MX 9603890A
Authority
MX
Mexico
Prior art keywords
milk
transgenic
glycoconjugates
heterologous
oligosaccharides
Prior art date
Application number
MX9603890A
Other languages
Spanish (es)
Other versions
MXPA96003890A (en
MX193700B (en
Inventor
Pedro Antonio Prieto
David Fletcher Smith
Richard Dale Cummings
John Joseph Kopchik
Pradif Mukerji
Kelley Wilson Moremen
James Michael Pierce
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX9603890A publication Critical patent/MX9603890A/en
Publication of MXPA96003890A publication Critical patent/MXPA96003890A/en
Publication of MX193700B publication Critical patent/MX193700B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/832—Milk; colostrum

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Polymers & Plastics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention relates to the milk of a transgenic non-human mammal. The milk is characterized in that it contains heterologous components produced as the secondary gene products of a heterologous gene contained in the genome of the transgenic non-human mammal. The heterologous gene encodes a heterologous catalytic entity such as a human enzyme selected from the group consisting of glycosyltransferases, phosphorylases, hydroxylases, peptidases and sulfotransferases. Especially useful in the practice of the invention are human glycosyltransferases. The desired heterologous components include oligosaccharides, glycoconjugates. The oligosaccharides and glycoconjugates may be isolated from the milk of the transgenic mammals and used in the preparation of pharmaceuticals, diagnostic kits, nutritional products and the like. The whole transgenic milk may also be used to formulate nutritional products that provide special advantages. The transgenic milk may also be used in the production of specialized enteral nutritional products.
MX9603890A 1994-03-09 1995-01-24 Transgenic production of oligosaccharides and glycoconjugates. MX193700B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08208889 1994-03-09
US08/208,889 US5750176A (en) 1994-03-09 1994-03-09 Transgenic non-human mammal milk comprising 2'-fucosyl-lactose
PCT/US1995/000967 WO1995024495A1 (en) 1994-03-09 1995-01-24 Transgenic production of oligosaccharides and glycoconjugates

Publications (3)

Publication Number Publication Date
MX9603890A true MX9603890A (en) 1997-07-31
MXPA96003890A MXPA96003890A (en) 1997-12-01
MX193700B MX193700B (en) 1999-10-13

Family

ID=22776455

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9603890A MX193700B (en) 1994-03-09 1995-01-24 Transgenic production of oligosaccharides and glycoconjugates.

Country Status (8)

Country Link
US (1) US5750176A (en)
EP (1) EP0750673A1 (en)
JP (1) JPH09510094A (en)
AU (1) AU697523B2 (en)
CA (1) CA2184686A1 (en)
MX (1) MX193700B (en)
NZ (1) NZ279686A (en)
WO (1) WO1995024495A1 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204431B1 (en) 1994-03-09 2001-03-20 Abbott Laboratories Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk
US6166288A (en) * 1995-09-27 2000-12-26 Nextran Inc. Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
FR2751346A1 (en) * 1996-07-19 1998-01-23 Inst Nat Sante Rech Med PROCESS FOR THE PREPARATION OF NON-HUMAN TRANSGENIC MAMMALIAN ORGANS FOR THEIR TRANSPLANTATION IN MAN, AND NUCLEOTIDE SEQUENCES FOR THE IMPLEMENTATION OF SAID METHOD
US6045854A (en) * 1997-03-31 2000-04-04 Abbott Laboraties Nutritional formulations containing oligosaccharides
US5906982A (en) * 1997-03-31 1999-05-25 Abbott Laboratories Nutritional formulations containing Lacto-N-neoTetraose
US6677145B2 (en) 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US20030163845A1 (en) * 1998-09-02 2003-08-28 Pradip Mukerji Elongase genes and uses thereof
US7070970B2 (en) 1999-08-23 2006-07-04 Abbott Laboratories Elongase genes and uses thereof
DE19958985A1 (en) * 1999-12-07 2001-06-13 Nutricia Nv Oligosaccharide mixture
EP1197550A3 (en) * 2000-08-25 2002-11-20 Pfizer Products Inc. Methods and compositions for diagnosing and treating disorders involving angiogenesis
CA2435685C (en) 2001-01-25 2011-06-07 Abbott Laboratories Desaturase genes and uses thereof
US6635451B2 (en) * 2001-01-25 2003-10-21 Abbott Laboratories Desaturase genes and uses thereof
US7211656B2 (en) * 2002-01-30 2007-05-01 Abbott Laboratories Desaturase genes, enzymes encoded thereby, and uses thereof
US20040231010A1 (en) * 2003-01-09 2004-11-18 Murray James D. Lysozyme transgenic ungulates
WO2005055944A2 (en) 2003-12-05 2005-06-23 Cincinnati Children's Hospital Medical Center Oligosaccharide compositions and use thereof in the treatment of infection
US7456270B2 (en) * 2004-09-01 2008-11-25 Abbott Laboratories Δ6-desaturase genes and uses thereof
AU2006313660B2 (en) * 2005-11-14 2012-07-19 Nestec S.A. Oral tolerance promotion with glycated proteins
WO2009033011A1 (en) 2007-09-07 2009-03-12 Children's Hospital Medical Center Use of secretor, lewis and sialyl antigen levels as predictors for disease
US8030471B2 (en) * 2008-03-06 2011-10-04 Abbott Laboratories Plasmodium malariae and Plasmodium ovale genes and uses thereof
US8268981B2 (en) 2008-03-06 2012-09-18 Abbott Laboratories Plasmodium malariae and plasmodium ovale genes and uses thereof
AR073779A1 (en) * 2008-10-06 2010-12-01 Abbott Lab DELTA GENES -8 DESATURASA, ENZYMES CODED BY THEM AND THEIR USES
US8063193B2 (en) 2009-03-27 2011-11-22 Abbott Laboratories Nucleotide and amino acid sequences encoding an exported protein 1 derived from Plasmodium vivax and uses thereof
WO2011002931A2 (en) 2009-06-30 2011-01-06 Abbott Laboratories Markers of xmrv infection and uses thereof
JP2012532195A (en) 2009-07-06 2012-12-13 チルドレンズ ホスピタル メディカル センター Inhibition of inflammation by milk oligosaccharides
US8188335B2 (en) 2009-07-17 2012-05-29 Abbott Laboratories Δ9-elongase for production of polyunsaturated fatty acid-enriched oils
ES2680920T3 (en) 2010-07-12 2018-09-11 The Regents Of The University Of California Bovine milk oligosaccharides
EP3984551A1 (en) 2011-12-02 2022-04-20 Rhode Island Hospital Vaccine for falciparum malaria
EP2833903B1 (en) 2012-04-05 2018-07-18 Gottfried Himmler Secretory immunoglobulin complex
CN105263319A (en) * 2013-02-13 2016-01-20 法国化学与生物科技实验室 Proteins with modified glycosylation and methods of production thereof
BR112015019341A2 (en) 2013-02-13 2017-08-22 Lab Francais Du Fractionnement ANTI-TNF-ALPHA ANTIBODY, COMPOSITION COMPRISING THE ANTIBODY, METHOD FOR PRODUCING A POPULATION OF ANTIBODIES, MAMMARY GLAND EPITHELIAL CELLS, TRANSGENIC NON-HUMAN MAMMAL, AND, MONOCLONAL ANTI-TNF ANTIBODY COMPOSITION
WO2014130789A1 (en) 2013-02-21 2014-08-28 Children's Hospital Medical Center Use of glycans and glycosyltransferases for diagnosing/monitoring inflammatory bowel disease
US10857167B2 (en) 2015-04-28 2020-12-08 Children's Hospital Medical Center Use of oligosaccharide compositions to enhance weight gain
US11524986B2 (en) 2018-07-11 2022-12-13 Ohio University Peptide-based inhibitors of growth hormone action and methods of use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435363A (en) * 1981-07-02 1984-03-06 Exxon Nuclear Company, Inc. Continuous countercurrent liquid-solids contactor
DE3334167A1 (en) * 1983-09-21 1985-04-04 Siemens AG, 1000 Berlin und 8000 München SEMICONDUCTOR DIODE
US5366894A (en) * 1986-06-30 1994-11-22 Pharmaceutical Proteins Limited Peptide production
GB8615942D0 (en) * 1986-06-30 1986-08-06 Animal & Food Research Council Peptide production
WO1988001648A1 (en) * 1986-08-28 1988-03-10 Immunex Corporation Expression of heterologous proteins by transgenic lactating mammals
EP0832981A1 (en) * 1987-02-17 1998-04-01 Pharming B.V. DNA sequences to target proteins to the mammary gland for efficient secretion
GB8826446D0 (en) * 1988-11-11 1988-12-14 Agricultural & Food Res Peptide production
US5032519A (en) * 1989-10-24 1991-07-16 The Regents Of The Univ. Of California Method for producing secretable glycosyltransferases and other Golgi processing enzymes
EP0502976B1 (en) * 1989-12-01 1996-07-03 Pharming B.V. Production of recombinant polypeptides by bovine species and transgenic methods
US5180674A (en) * 1990-04-16 1993-01-19 The Trustees Of The University Of Pennsylvania Saccharide compositions, methods and apparatus for their synthesis
ATE352612T1 (en) * 1990-08-29 2007-02-15 Pharming Intellectual Pty Bv HOMOLOGOUS RECOMBINATION IN MAMMAL CELLS
US5198466A (en) * 1990-11-09 1993-03-30 Warner-Lambert Company Oxysulfonyl urea acat inhibitors
DK8892D0 (en) * 1992-01-23 1992-01-23 Symbicom Ab HUMANT PROTEING

Also Published As

Publication number Publication date
EP0750673A1 (en) 1997-01-02
CA2184686A1 (en) 1995-09-14
AU1690195A (en) 1995-09-25
WO1995024495A1 (en) 1995-09-14
JPH09510094A (en) 1997-10-14
MX193700B (en) 1999-10-13
NZ279686A (en) 1998-04-27
US5750176A (en) 1998-05-12
AU697523B2 (en) 1998-10-08

Similar Documents

Publication Publication Date Title
MX9603890A (en) Transgenic production of oligosaccharides and glycoconjugates.
Stanley et al. Chinese hamster ovary cells selected for resistance to the cytotoxicity of phytohemagglutinin are deficient in a UDP-N-acetylglucosamine--glycoprotein N-acetylglucosaminyltransferase activity.
AU5445396A (en) Improved enzymatic synthesis of oligosaccharides
BG102107A (en) Improvement of plant yields
RS18304A (en) Self processing plants and plant parts
ATE240637T1 (en) LYSOMAL PROTEINS PRODUCED IN THE MILK OF NON-HUMAN TRANSGENIC ANIMALS
MX9603892A (en) Transgenic animals producing oligosaccharides and glycoconjugates.
HUP0203736A2 (en) Infant formula with improved protein content
FR2771600B1 (en) PREPARATION OF FOOD PRODUCTS BY FERMENTATION OF A MIXTURE OF SOY JUICE AND CEREAL HYDROLYSAT BY STREPTOCOCCUS THERMOPHILUS
DK0568530T3 (en) Dietary fiber-containing food product and process for making this product
NZ289720A (en) Nucleic acids coding for a telomerase, a ribonucleoprotein enzyme involved in telomere synthesis
AU7714594A (en) Substituted ketone derivatives as inhibitors of interleukin-1beta converting enzyme
AU4589089A (en) The use of bacteriolytic enzyme product and protease as additive for improving feed conversion in livestock production
HU9403343D0 (en) New pharmaceutical uses of krill enzymes
AU2932892A (en) Process for producing food and drink
EP0220107A3 (en) Use of angiotensin-converting enzyme inhibitors in macular degeneration
DK41892D0 (en)
DE69722437D1 (en) FOOD INDUCED ANTISECRETORIC PROTEINS
EP0943001B8 (en) Heat stable mutants of starch biosynthesis enzymes
WO1995007357A3 (en) Promoters
AU3063492A (en) Compositions and methods for template-dependent enzymatic synthesis of nucleic acid
WO2002048331A3 (en) Active-site engineering of nucleotidyltransferases and enzymatic methods for the synthesis of natural and 'unnatural' udp- and nucleotide sugars
ES8503934A1 (en) Process for the manufacture of proteinated foodstuffs and various by-products from cereals.
GT200000138CA (en) GENE OF STEPTOMYCES AVERMITILIS THAT DIRECTS THE RELATIONSHIP OF AVERMECTINES B1: B2 (FRACTIONARY APPLICATION NO.3, DERIVED FROM LAPATENT PI-2000-0138)
HUT57270A (en) Process for improving enzyme-activity and synthesis-productivity of organisma

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees