MX9602774A - Dispositivo de escala mediana, para preparacion de muestra y sistemas para determinacion y procesamiento de analitos. - Google Patents

Dispositivo de escala mediana, para preparacion de muestra y sistemas para determinacion y procesamiento de analitos.

Info

Publication number
MX9602774A
MX9602774A MX9602774A MX9602774A MX9602774A MX 9602774 A MX9602774 A MX 9602774A MX 9602774 A MX9602774 A MX 9602774A MX 9602774 A MX9602774 A MX 9602774A MX 9602774 A MX9602774 A MX 9602774A
Authority
MX
Mexico
Prior art keywords
sample preparation
preparation device
analytes
determination
systems
Prior art date
Application number
MX9602774A
Other languages
English (en)
Other versions
MXPA96002774A (es
Inventor
Peter Wilding
Larry J Kricka
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/338,369 external-priority patent/US5726026A/en
Priority claimed from US08/338,728 external-priority patent/US5587128A/en
Priority claimed from US08/338,380 external-priority patent/US5744366A/en
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of MX9602774A publication Critical patent/MX9602774A/es
Publication of MXPA96002774A publication Critical patent/MXPA96002774A/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/02—Inorganic material
    • B01D71/0213—Silicon
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/02—Inorganic material
    • B01D71/0215—Silicon carbide; Silicon nitride; Silicon oxycarbide
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00826—Quartz
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00828—Silicon wafers or plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00831—Glass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

Un dispositivo de escala mediana para preparacion de muestra capaz de proporcionar muestras para prueba de microvolumenes, separadas en una fraccion de célula enriquecida y una fraccion de reducido contenido de célula, para efectuar diferentes análisis, tales como ensayos de aglutamiento, determinaciones que involucran amplificacion de polinucleotido y similares. Se describen también los sistemas analíticos que incluyen tales dispositivos.
MXPA/A/1996/002774A 1994-11-14 1996-07-15 Dispositivo de escala mediana, para preparacion de muestra y sistemas para determinacion y procesamiento de analitos MXPA96002774A (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US08/338,369 US5726026A (en) 1992-05-01 1994-11-14 Mesoscale sample preparation device and systems for determination and processing of analytes
US08/338,728 US5587128A (en) 1992-05-01 1994-11-14 Mesoscale polynucleotide amplification devices
US08338728 1994-11-14
US08338369 1994-11-14
US08/338,380 US5744366A (en) 1992-05-01 1994-11-14 Mesoscale devices and methods for analysis of motile cells
US08338380 1994-11-14
PCT/US1995/014825 WO1996014934A1 (en) 1994-11-14 1995-11-13 Mesoscale sample preparation device and systems for determination and processing of analytes

Publications (2)

Publication Number Publication Date
MX9602774A true MX9602774A (es) 1997-07-31
MXPA96002774A MXPA96002774A (es) 1997-12-01

Family

ID=

Also Published As

Publication number Publication date
DE69533159T2 (de) 2005-07-21
ATE269160T1 (de) 2004-07-15
WO1996014934A1 (en) 1996-05-23
JP3220158B2 (ja) 2001-10-22
CA2181190C (en) 2001-02-06
CA2181190A1 (en) 1996-05-23
CN1143917A (zh) 1997-02-26
DE69533159D1 (de) 2004-07-22
EP0739240A1 (en) 1996-10-30
AU4236996A (en) 1996-06-06
EP0739240B1 (en) 2004-06-16
AU704277B2 (en) 1999-04-15
CN1110369C (zh) 2003-06-04
JPH09509498A (ja) 1997-09-22

Similar Documents

Publication Publication Date Title
CA2181190A1 (en) Mesoscale Sample Preparation Device and Systems for Determination and Processing of Analytes
CA2115276A1 (en) Reagent compositions for analytical testing
IL109817A0 (en) Improved method and analytical system for performing fibrinogen assays accurately, rapidly and simply
CA2383262A1 (en) Analytical test device with substrate having oriented through going channels and improved methods and apparatus for using same
MY129171A (en) Chromatographic assay device and method for detecting the presence of an analyte in a blood sample
EP0961110A3 (en) Device for preparing thin liquid samples for microscopic analysis
WO1999016781A3 (de) Automatisierbare universell anwendbare probenvorbereitungsmethode
CA2346951A1 (en) Structure and method for automatic analysis of samples
ZA978630B (en) Method for collecting samples of liquid specimens for analytical testing.
WO1993022055A3 (en) Fluid handling in microfabricated analytical devices
WO2000008466A3 (en) Analytical test device and method
AU4817897A (en) Immunoassay device employing applicator component and self-contained, external reagent container
GR3036073T3 (en) Analytical test apparatus with on board negative and positive control.
AU9066998A (en) Use of check surfaces for identifying disturbing samples in a detection procedure
CA2195875A1 (en) Devices and methods utilizing arrays of structures for analyte capture
CA2096389A1 (en) Analysis of samples by capillary electrophoretic immunosubtraction
WO2003106964A3 (en) HIGH EFFICIENCY METHODS AND DEVICES FOR ASSAYING ANALYTES IN A FLUID SAMPLE
EP0814336A3 (en) Reagents and methods for releasing and measuring lead from biological matrices
WO2004011607A3 (en) Reagent and method for determination of a substance using an immunoaggregator
GB9709821D0 (en) Allergy assay
DK158481C (da) Fremgangsmaade til analyse af antistoffer samt reagens dertil
ES2112320T3 (es) Procedimientos y reactivos con captura de iones que permiten determinar el contenido en digoxina.
WO2003046514A3 (en) Particle-based ligand assay with extended dynamic range
NO162535C (no) Innretning for uttrekking og kondisjonering av proever av materialer i fast, flytende eller gassform, for analyse derav.
CA2285219A1 (en) Detection of low level analytes in samples

Legal Events

Date Code Title Description
FG Grant or registration