MX9403382A - Xantinas sustituidas en la posicion 8 como agentes receptores selectivosde adenosina. - Google Patents

Xantinas sustituidas en la posicion 8 como agentes receptores selectivosde adenosina.

Info

Publication number
MX9403382A
MX9403382A MX9403382A MX9403382A MX9403382A MX 9403382 A MX9403382 A MX 9403382A MX 9403382 A MX9403382 A MX 9403382A MX 9403382 A MX9403382 A MX 9403382A MX 9403382 A MX9403382 A MX 9403382A
Authority
MX
Mexico
Prior art keywords
adenosine
ladenosine
physiological effects
selective receiving
receiving agents
Prior art date
Application number
MX9403382A
Other languages
English (en)
Inventor
Norton P Peet
Nelsen L Lentz
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of MX9403382A publication Critical patent/MX9403382A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La presente invención se refiere a los derivados de xantina que actúan enforma selectiva en los receptores de adenosina y los cuales actúan engeneral como antagonistas de adenosinas. A partir de los estudios in vitrose sabe que los efectos fisiológicos específicos se pueden distinguir comoun resultado de esta selectividad y que la actividad receptora de laadenosina in vitro tiene correlación con la actividad receptora de laadenosina in vivo. Las formulaciones farmacéuticas de los compuestos enmateria se pueden preparar sobre las bases de la actividad del enlaceselectivo de los compuestos descritos en la presente los cuales mejoraránciertos efectos fisiológicos mientras que reducen otros, tales como ladisminución de la presión sanguínea sin disminuir el ritmo cardiaco.
MX9403382A 1993-05-06 1994-05-06 Xantinas sustituidas en la posicion 8 como agentes receptores selectivosde adenosina. MX9403382A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5852393A 1993-05-06 1993-05-06

Publications (1)

Publication Number Publication Date
MX9403382A true MX9403382A (es) 1995-01-31

Family

ID=22017346

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9403382A MX9403382A (es) 1993-05-06 1994-05-06 Xantinas sustituidas en la posicion 8 como agentes receptores selectivosde adenosina.

Country Status (14)

Country Link
US (1) US5734052A (es)
EP (1) EP0697020A1 (es)
JP (1) JPH08509977A (es)
CN (1) CN1043473C (es)
AU (1) AU676323B2 (es)
CA (1) CA2159989C (es)
FI (1) FI955257A0 (es)
HU (1) HUT72327A (es)
IL (1) IL109521A (es)
MX (1) MX9403382A (es)
NO (1) NO954399L (es)
NZ (1) NZ265790A (es)
WO (1) WO1994026744A1 (es)
ZA (1) ZA943015B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025362A (en) * 1998-08-31 2000-02-15 Fukunaga; Atsuo F. Uses of xanthine compounds
US6258794B1 (en) 1999-12-14 2001-07-10 The Mclean Hospital Corporation Treatment of mental conditions including depression
US8871751B2 (en) * 2008-01-18 2014-10-28 The Board Of Trustees Of The University Of Illinois Compositions and methods relating to nuclear hormone and steroid hormone receptors including inhibitors of estrogen receptor alpha-mediated gene expression and inhibition of breast cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1435916A (en) * 1972-05-11 1976-05-19 Beecham Group Ltd Pharmaceutical weight-reducing compositions
US4772607A (en) * 1986-05-20 1988-09-20 Warner-Lambert Company Dialkenyl derivatives of xanthine, pharmaceutical compositions and methods of use therefor
US5047534A (en) * 1990-03-26 1991-09-10 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
DE4019892A1 (de) * 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
US5087827A (en) * 1991-02-11 1992-02-11 Tektronix, Inc. Variable voltage transition circuit
US5208240A (en) * 1991-03-12 1993-05-04 Merrell Dow Pharmaceuticals Inc. 8-substituted purines as selective adenosine receptor agents

Also Published As

Publication number Publication date
HU9503154D0 (en) 1996-01-29
FI955257A (fi) 1995-11-02
ZA943015B (en) 1995-01-30
NZ265790A (en) 1996-10-28
IL109521A0 (en) 1994-08-26
US5734052A (en) 1998-03-31
AU6703294A (en) 1994-12-12
CN1043473C (zh) 1999-05-26
EP0697020A1 (en) 1996-02-21
WO1994026744A1 (en) 1994-11-24
NO954399D0 (no) 1995-11-03
IL109521A (en) 1999-09-22
NO954399L (no) 1996-01-08
CA2159989C (en) 1994-11-24
FI955257A0 (fi) 1995-11-02
CA2159989A1 (en) 1994-11-24
JPH08509977A (ja) 1996-10-22
AU676323B2 (en) 1997-03-06
CN1122599A (zh) 1996-05-15
HUT72327A (en) 1996-04-29

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees