MX9302869A - NEW DERIVATIVES OF DIHYDROXYBENCILAMINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. - Google Patents

NEW DERIVATIVES OF DIHYDROXYBENCILAMINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.

Info

Publication number
MX9302869A
MX9302869A MX9302869A MX9302869A MX9302869A MX 9302869 A MX9302869 A MX 9302869A MX 9302869 A MX9302869 A MX 9302869A MX 9302869 A MX9302869 A MX 9302869A MX 9302869 A MX9302869 A MX 9302869A
Authority
MX
Mexico
Prior art keywords
preparation
pharmaceutical compositions
dihydroxybencilamine
contain
aryloxycarbonyl
Prior art date
Application number
MX9302869A
Other languages
Spanish (es)
Inventor
Janine Boiziau
Huixiong Chen
Christiane Garbay
Jean-Bernard Le Pecq
Fabienne Parker
Bernard-Pierre Roques
Bruno Tocque
Original Assignee
Rhone Poulenc Rorer Sa
Inst Nat Sante Et De
Rech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa, Inst Nat Sante Et De, Rech filed Critical Rhone Poulenc Rorer Sa
Publication of MX9302869A publication Critical patent/MX9302869A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/64—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen los nuevos derivados de la 2, 5-dihidroxibencilamina de fórmula general (I), la preparación y las composiciones farmacéuticas que los contienen. En la fórmula general (I), uno de los símbolos R1 ó R2 representa un átomo de hidrógeno o de halógeno o radical hidroxi, alcoxi, alcoilcarboniloxi, arilcarboniloxi, mercapto, alcoiltio, amino, formilamino, alcoilcarbonilamino, arilcarbonilamino y el otro representa un radical alcoxi, alcoximetilo, alcoilcarbonilo, arilcarbonilo, alcoiloxicarbonilo, ariloxicarbonilo, alqueniloxicarbonilo, ariloxicarbonilo, carbamoilo o tiocarbamoilo en donde el átomo de nitrógeno esta eventualmente sustituido por uno o dos radicales alcoilos o fenilos, los radicales alcoilos, fenilos y arilos están eventualmente sustituidos. Los nuevos productos de fórmula (I) manifiestan una actividad antitumoral notable.Novel 2,5-dihydroxybenzylamine derivatives of general formula (I), the preparation and the pharmaceutical compositions containing them are described. In the general formula (I), one of the symbols R1 or R2 represents a hydrogen or halogen atom or hydroxy, alkoxy, alkoxycarbonyloxy, arylcarbonyloxy, mercapto, alkoylthio, amino, formylamino, alkoxycarbonylamino, arylcarbonylamino radical and the other represents a radical alkoxy, alkoxymethyl, alkoxycarbonyl, arylcarbonyl, alkyloxycarbonyl, aryloxycarbonyl, alkenyloxycarbonyl, aryloxycarbonyl, carbamoyl or thiocarbamoyl in which the nitrogen atom is optionally substituted by one or two alkyls or phenyl radicals, the alkyls, phenyl and aryl radicals. The new products of formula (I) show remarkable anti-tumor activity.

MX9302869A 1992-05-18 1993-05-17 NEW DERIVATIVES OF DIHYDROXYBENCILAMINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. MX9302869A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9205980A FR2691145A1 (en) 1992-05-18 1992-05-18 Novel dihydroxybenzylamine derivatives, their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
MX9302869A true MX9302869A (en) 1993-11-01

Family

ID=9429866

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9302869A MX9302869A (en) 1992-05-18 1993-05-17 NEW DERIVATIVES OF DIHYDROXYBENCILAMINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.

Country Status (8)

Country Link
EP (1) EP0641311A1 (en)
JP (1) JPH07506585A (en)
AU (1) AU4075693A (en)
FR (1) FR2691145A1 (en)
MX (1) MX9302869A (en)
TW (1) TW252095B (en)
WO (1) WO1993023364A1 (en)
ZA (1) ZA933426B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2321307A1 (en) * 1998-02-27 1999-09-02 Venkatachala L. Narayanan Disubstituted lavendustin a analogs and pharmaceutical compositions comprising the analogs
US7208143B2 (en) * 2004-09-29 2007-04-24 Isp Investments Inc. Antiperspirant compositions
US7166275B2 (en) * 2003-07-11 2007-01-23 Isp Investments Inc. Compositions containing phenethyl aryl esters as solubilizing agents for active organic compounds
JP2006008642A (en) * 2004-06-29 2006-01-12 Sumitomo Bakelite Co Ltd Aminophenol compound, thermosetting compound and method for producing the same
US20090298905A1 (en) 2005-04-15 2009-12-03 Fernando Pedro Cossio Nitrogenatd trans-stilbene analogs, method for the obtention and medical applications thereof
US11926574B2 (en) 2021-06-08 2024-03-12 Atai Therapeutics Inc. Dimethoxyphenylalkylamine activators of serotonin receptors
JP2024522174A (en) 2021-06-09 2024-06-11 アタイ セラピューティクス， インコーポレイテッド Novel prodrugs and conjugates of dimethyltryptamine
WO2023129909A1 (en) 2021-12-27 2023-07-06 ATAI Life Sciences AG Aminotetraline activators of serotonin receptors
WO2023129956A2 (en) 2021-12-30 2023-07-06 ATAI Life Sciences AG Dimethyltryptamine analogues as nitric oxide delivery drugs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2120091A1 (en) * 1971-04-24 1972-11-09 Agfa-Gevaert Ag, 5090 Leverkusen Color former for the peroxide color intensification process

Also Published As

Publication number Publication date
WO1993023364A1 (en) 1993-11-25
FR2691145A1 (en) 1993-11-19
EP0641311A1 (en) 1995-03-08
JPH07506585A (en) 1995-07-20
ZA933426B (en) 1994-08-02
AU4075693A (en) 1993-12-13
TW252095B (en) 1995-07-21

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