MX9301513A - QUINOLONE DISULFIDE. - Google Patents

QUINOLONE DISULFIDE.

Info

Publication number
MX9301513A
MX9301513A MX9301513A MX9301513A MX9301513A MX 9301513 A MX9301513 A MX 9301513A MX 9301513 A MX9301513 A MX 9301513A MX 9301513 A MX9301513 A MX 9301513A MX 9301513 A MX9301513 A MX 9301513A
Authority
MX
Mexico
Prior art keywords
disulfide
alkyl
quinolone
formula
see
Prior art date
Application number
MX9301513A
Other languages
Spanish (es)
Inventor
Luigi Ratti
Original Assignee
Geofarma Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geofarma Srl filed Critical Geofarma Srl
Publication of MX9301513A publication Critical patent/MX9301513A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describe un disulfuro de quinolona de la fórmula (I) ver formula (1). En donde R es alquilo se c1-c4, un proceso para la preparación del mismo que comprenda hacer reaccionar un 2,3,5-trifluoro-4-(4-metilpiperazin-1-il)benzoilac etato de alquilo (II) ver figura (2). Con N,N-dimetilformamida dimetilacetal, seguido por la reacción con 2-aminoetanotiol, ciclización intramolecular en la presencia de una base. El producto (I) se transforma en rufloxacin en sus sales farmacéuticamente aceptables por reducción del disulfuro (I), la ciclización final e hidrólisis.A quinolone disulfide of the formula (I) is described see formula (1). Where R is C1-c4 alkyl, a process for the preparation thereof comprising reacting an alkyl (II) 2,3,5-trifluoro-4- (4-methylpiperazin-1-yl) benzoylacetate see figure (2). With N, N-dimethylformamide dimethylacetal, followed by reaction with 2-aminoethanothiol, intramolecular cyclization in the presence of a base. Product (I) is transformed into rufloxacin into its pharmaceutically acceptable salts by reduction of disulfide (I), final cyclization, and hydrolysis.

MX9301513A 1992-03-18 1993-03-18 QUINOLONE DISULFIDE. MX9301513A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000630A ITMI920630A1 (en) 1992-03-18 1992-03-18 QUINOLONIC DISULFIDE

Publications (1)

Publication Number Publication Date
MX9301513A true MX9301513A (en) 1993-11-01

Family

ID=11362488

Family Applications (2)

Application Number Title Priority Date Filing Date
MX9301512A MX9301512A (en) 1992-03-18 1993-03-18 PROCESS FOR THE PREPARATION OF RUFLOXACIN AND SALTS OF THE SAME.
MX9301513A MX9301513A (en) 1992-03-18 1993-03-18 QUINOLONE DISULFIDE.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX9301512A MX9301512A (en) 1992-03-18 1993-03-18 PROCESS FOR THE PREPARATION OF RUFLOXACIN AND SALTS OF THE SAME.

Country Status (3)

Country Link
IL (2) IL105076A0 (en)
IT (1) ITMI920630A1 (en)
MX (2) MX9301512A (en)

Also Published As

Publication number Publication date
IL105076A0 (en) 1993-07-08
IL105075A0 (en) 1993-07-08
MX9301512A (en) 1993-11-01
ITMI920630A0 (en) 1992-03-18
ITMI920630A1 (en) 1993-09-19

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