MX9301513A - QUINOLONE DISULFIDE. - Google Patents
QUINOLONE DISULFIDE.Info
- Publication number
- MX9301513A MX9301513A MX9301513A MX9301513A MX9301513A MX 9301513 A MX9301513 A MX 9301513A MX 9301513 A MX9301513 A MX 9301513A MX 9301513 A MX9301513 A MX 9301513A MX 9301513 A MX9301513 A MX 9301513A
- Authority
- MX
- Mexico
- Prior art keywords
- disulfide
- alkyl
- quinolone
- formula
- see
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describe un disulfuro de quinolona de la fórmula (I) ver formula (1). En donde R es alquilo se c1-c4, un proceso para la preparación del mismo que comprenda hacer reaccionar un 2,3,5-trifluoro-4-(4-metilpiperazin-1-il)benzoilac etato de alquilo (II) ver figura (2). Con N,N-dimetilformamida dimetilacetal, seguido por la reacción con 2-aminoetanotiol, ciclización intramolecular en la presencia de una base. El producto (I) se transforma en rufloxacin en sus sales farmacéuticamente aceptables por reducción del disulfuro (I), la ciclización final e hidrólisis.A quinolone disulfide of the formula (I) is described see formula (1). Where R is C1-c4 alkyl, a process for the preparation thereof comprising reacting an alkyl (II) 2,3,5-trifluoro-4- (4-methylpiperazin-1-yl) benzoylacetate see figure (2). With N, N-dimethylformamide dimethylacetal, followed by reaction with 2-aminoethanothiol, intramolecular cyclization in the presence of a base. Product (I) is transformed into rufloxacin into its pharmaceutically acceptable salts by reduction of disulfide (I), final cyclization, and hydrolysis.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000630A ITMI920630A1 (en) | 1992-03-18 | 1992-03-18 | QUINOLONIC DISULFIDE |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9301513A true MX9301513A (en) | 1993-11-01 |
Family
ID=11362488
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9301512A MX9301512A (en) | 1992-03-18 | 1993-03-18 | PROCESS FOR THE PREPARATION OF RUFLOXACIN AND SALTS OF THE SAME. |
MX9301513A MX9301513A (en) | 1992-03-18 | 1993-03-18 | QUINOLONE DISULFIDE. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9301512A MX9301512A (en) | 1992-03-18 | 1993-03-18 | PROCESS FOR THE PREPARATION OF RUFLOXACIN AND SALTS OF THE SAME. |
Country Status (3)
Country | Link |
---|---|
IL (2) | IL105076A0 (en) |
IT (1) | ITMI920630A1 (en) |
MX (2) | MX9301512A (en) |
-
1992
- 1992-03-18 IT IT000630A patent/ITMI920630A1/en not_active IP Right Cessation
-
1993
- 1993-03-16 IL IL105076A patent/IL105076A0/en unknown
- 1993-03-16 IL IL105075A patent/IL105075A0/en unknown
- 1993-03-18 MX MX9301512A patent/MX9301512A/en unknown
- 1993-03-18 MX MX9301513A patent/MX9301513A/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL105076A0 (en) | 1993-07-08 |
IL105075A0 (en) | 1993-07-08 |
MX9301512A (en) | 1993-11-01 |
ITMI920630A0 (en) | 1992-03-18 |
ITMI920630A1 (en) | 1993-09-19 |
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