MX9301512A - PROCESS FOR THE PREPARATION OF RUFLOXACIN AND SALTS OF THE SAME. - Google Patents

PROCESS FOR THE PREPARATION OF RUFLOXACIN AND SALTS OF THE SAME.

Info

Publication number
MX9301512A
MX9301512A MX9301512A MX9301512A MX9301512A MX 9301512 A MX9301512 A MX 9301512A MX 9301512 A MX9301512 A MX 9301512A MX 9301512 A MX9301512 A MX 9301512A MX 9301512 A MX9301512 A MX 9301512A
Authority
MX
Mexico
Prior art keywords
rufloxacin
formula
salts
preparation
same
Prior art date
Application number
MX9301512A
Other languages
Spanish (es)
Inventor
Luigi Ratti
Original Assignee
Geofarma Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geofarma Srl filed Critical Geofarma Srl
Publication of MX9301512A publication Critical patent/MX9301512A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

El rufloxacin se prepara reduciendo un disulfuro de quinolona de la fórmula (II) ver formula (2). Sometiendo la 2-mercaptometil quinolona obtenida de esta manera de la fórmula (III) ver la figura (3). A una ciclización en un medio base e hidrolizado el éster de rufloxacin obtenido de esta manera, para aislar rufloxacin. Un nuevo método de hidrolizar el éster de rufloxacin para dar rufloxacin y sus sales farmacéuticamente aceptables, también se describe.Rufloxacin is prepared by reducing a quinolone disulfide of formula (II) see formula (2). Submitting the 2-mercaptomethyl quinolone thus obtained from formula (III) see figure (3). Upon cyclization in a base medium and hydrolyzed the rufloxacin ester thus obtained, to isolate rufloxacin. A new method of hydrolyzing the rufloxacin ester to give rufloxacin and its pharmaceutically acceptable salts, is also described.

MX9301512A 1992-03-18 1993-03-18 PROCESS FOR THE PREPARATION OF RUFLOXACIN AND SALTS OF THE SAME. MX9301512A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000630A ITMI920630A1 (en) 1992-03-18 1992-03-18 QUINOLONIC DISULFIDE

Publications (1)

Publication Number Publication Date
MX9301512A true MX9301512A (en) 1993-11-01

Family

ID=11362488

Family Applications (2)

Application Number Title Priority Date Filing Date
MX9301512A MX9301512A (en) 1992-03-18 1993-03-18 PROCESS FOR THE PREPARATION OF RUFLOXACIN AND SALTS OF THE SAME.
MX9301513A MX9301513A (en) 1992-03-18 1993-03-18 QUINOLONE DISULFIDE.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX9301513A MX9301513A (en) 1992-03-18 1993-03-18 QUINOLONE DISULFIDE.

Country Status (3)

Country Link
IL (2) IL105076A0 (en)
IT (1) ITMI920630A1 (en)
MX (2) MX9301512A (en)

Also Published As

Publication number Publication date
MX9301513A (en) 1993-11-01
IL105076A0 (en) 1993-07-08
IL105075A0 (en) 1993-07-08
ITMI920630A0 (en) 1992-03-18
ITMI920630A1 (en) 1993-09-19

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