MX9301344A - METHOD FOR PRODUCING CARBOHYDRATES. - Google Patents

METHOD FOR PRODUCING CARBOHYDRATES.

Info

Publication number
MX9301344A
MX9301344A MX9301344A MX9301344A MX9301344A MX 9301344 A MX9301344 A MX 9301344A MX 9301344 A MX9301344 A MX 9301344A MX 9301344 A MX9301344 A MX 9301344A MX 9301344 A MX9301344 A MX 9301344A
Authority
MX
Mexico
Prior art keywords
oligosaccharides
cell adhesion
produced
producing carbohydrates
glcnac
Prior art date
Application number
MX9301344A
Other languages
Spanish (es)
Inventor
Sau-Chi Betty Yan
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX9301344A publication Critical patent/MX9301344A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6464Protein C (3.4.21.69)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21069Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Amplifiers (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

The invention relates to oligosaccharides with the sequence GalNAc beta (1-4) (Fuc alpha (1-3) GlcNAc. They are produced by incubating Human Kidney 293 cells and isolating the novel oligosaccharides from the peptide produced. oligosaccharides can be used to act as high affinity ligands of certain cell adhesion receptors, and may be used to prevent or reduce cell adhesion and inflammation.
MX9301344A 1992-03-12 1993-03-11 METHOD FOR PRODUCING CARBOHYDRATES. MX9301344A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84986892A 1992-03-12 1992-03-12

Publications (1)

Publication Number Publication Date
MX9301344A true MX9301344A (en) 1993-09-01

Family

ID=25306715

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9301344A MX9301344A (en) 1992-03-12 1993-03-11 METHOD FOR PRODUCING CARBOHYDRATES.

Country Status (23)

Country Link
EP (1) EP0565241B1 (en)
JP (1) JP3171506B2 (en)
KR (1) KR930019696A (en)
CN (1) CN1079967A (en)
AT (1) ATE137241T1 (en)
AU (1) AU661762B2 (en)
BR (1) BR9301136A (en)
CA (1) CA2091521A1 (en)
CY (1) CY1947A (en)
CZ (1) CZ39093A3 (en)
DE (1) DE69302317T2 (en)
DK (1) DK0565241T3 (en)
ES (1) ES2088227T3 (en)
FI (1) FI931086A (en)
GR (1) GR3020406T3 (en)
HK (1) HK132396A (en)
HU (1) HUT69613A (en)
IL (1) IL105018A0 (en)
MX (1) MX9301344A (en)
NO (1) NO930890L (en)
NZ (1) NZ247105A (en)
YU (1) YU16993A (en)
ZA (1) ZA931723B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002081723A1 (en) * 2001-04-02 2002-10-17 Keio University Process for producing oligosaccharide chain
FI20011664A (en) 2001-08-17 2003-02-18 Carbion Oy Cancer-specific oligosaccharide sequences and their use
US7943763B2 (en) * 2002-07-05 2011-05-17 Otsuka Chemical Holdings Co., Ltd. Process for preparing glycopeptides having asparagine-linked oligosaccharides, and the glycopeptides
JP4790271B2 (en) * 2002-12-26 2011-10-12 康宏 梶原 Three-branched sugar chain asparagine derivatives, the sugar chain asparagine, the sugar chain, and methods for producing them
JP3884725B2 (en) 2003-06-03 2007-02-21 三菱電機株式会社 Waveguide device

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5009889A (en) * 1987-12-31 1991-04-23 Oklahoma Medical Research Foundation Treatment of dysfunctional vascular endothelium using activated protein C

Also Published As

Publication number Publication date
JP3171506B2 (en) 2001-05-28
IL105018A0 (en) 1993-07-08
HUT69613A (en) 1995-09-28
YU16993A (en) 1996-02-19
CZ39093A3 (en) 1994-03-16
AU3519993A (en) 1993-09-16
HU9300687D0 (en) 1993-05-28
CN1079967A (en) 1993-12-29
EP0565241A1 (en) 1993-10-13
CY1947A (en) 1993-03-12
EP0565241B1 (en) 1996-04-24
DK0565241T3 (en) 1996-05-28
GR3020406T3 (en) 1996-09-30
BR9301136A (en) 1993-09-28
NO930890D0 (en) 1993-03-11
CA2091521A1 (en) 1993-09-13
DE69302317D1 (en) 1996-05-30
DE69302317T2 (en) 1996-09-19
HK132396A (en) 1996-07-26
NO930890L (en) 1993-09-13
AU661762B2 (en) 1995-08-03
JPH0625302A (en) 1994-02-01
NZ247105A (en) 1994-11-25
ES2088227T3 (en) 1996-08-01
FI931086A0 (en) 1993-03-11
FI931086A (en) 1993-09-13
ATE137241T1 (en) 1996-05-15
ZA931723B (en) 1994-09-10
KR930019696A (en) 1993-10-18

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