MX9300482A - PROCESS FOR THE PREPARATION OF 2-AMINO-6-CHLOROPURINE. - Google Patents

PROCESS FOR THE PREPARATION OF 2-AMINO-6-CHLOROPURINE.

Info

Publication number
MX9300482A
MX9300482A MX9300482A MX9300482A MX9300482A MX 9300482 A MX9300482 A MX 9300482A MX 9300482 A MX9300482 A MX 9300482A MX 9300482 A MX9300482 A MX 9300482A MX 9300482 A MX9300482 A MX 9300482A
Authority
MX
Mexico
Prior art keywords
chloropurine
amino
preparation
acyl group
diacylated
Prior art date
Application number
MX9300482A
Other languages
Spanish (es)
Inventor
Christopher Robert Jame Killen
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of MX9300482A publication Critical patent/MX9300482A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describe un proceso para la preparación de 2-amino-6-cloropurina que comprende la reacción de un derivado 2,9-diacilado de guanina con un agente de cloración, en presencia de un catalizador de transferencia de fase que contienen iones cloruro y después de esto la eliminación del grupo 9-acilo y el grupo 2-acilo mediante hidrólisis.A process for the preparation of 2-amino-6-chloropurine is described which comprises the reaction of a 2,9-diacylated guanine derivative with a chlorinating agent, in the presence of a phase transfer catalyst containing chloride ions and then hence the removal of the 9-acyl group and the 2-acyl group by hydrolysis.

MX9300482A 1992-01-30 1993-01-28 PROCESS FOR THE PREPARATION OF 2-AMINO-6-CHLOROPURINE. MX9300482A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929201961A GB9201961D0 (en) 1992-01-30 1992-01-30 Pharmaceuticals

Publications (1)

Publication Number Publication Date
MX9300482A true MX9300482A (en) 1994-07-29

Family

ID=10709516

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9300482A MX9300482A (en) 1992-01-30 1993-01-28 PROCESS FOR THE PREPARATION OF 2-AMINO-6-CHLOROPURINE.

Country Status (10)

Country Link
EP (1) EP0625154A1 (en)
JP (1) JPH07503246A (en)
KR (1) KR950700299A (en)
AU (1) AU669874B2 (en)
CA (1) CA2117435A1 (en)
GB (1) GB9201961D0 (en)
MX (1) MX9300482A (en)
NZ (1) NZ246677A (en)
WO (1) WO1993015075A1 (en)
ZA (1) ZA93615B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4231036A1 (en) * 1992-09-17 1994-03-24 Basf Ag Process for the preparation of 2-amino-6-halopurines
JPH07133276A (en) * 1993-09-17 1995-05-23 Jiyuuzen Kagaku Kk Production of 2-acetylamono-6-chloropurine
DE4415196C1 (en) * 1994-04-30 1995-04-27 Boehringer Ingelheim Kg Improved process for the preparation of 2-amino-6-chloropurine and 2-acylamino-6-chloropurines
CA2189088C (en) 1995-11-09 2005-09-20 Masatoshi Sakai 2-amino-6-chloropurine and method for preparing the same
JP4223408B2 (en) 2002-04-04 2009-02-12 住友化学株式会社 Method for producing 2,6-dihalopurine
CN102336755B (en) * 2011-09-30 2013-03-27 浙江工业大学 Chemical synthesis method of 6-chloropurine
CN113214260B (en) * 2021-05-10 2022-04-01 上海凌凯医药科技有限公司 Synthesis method of 2-acetamido-9-acetyl purine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485225D1 (en) 1983-08-18 1991-12-05 Beecham Group Plc ANTIVIRAL GUANINE DERIVATIVES.
DE3582399D1 (en) 1984-09-20 1991-05-08 Beecham Group Plc PURINE DERIVATIVES AND THEIR PHARMACEUTICAL USE.
GB8507606D0 (en) * 1985-03-23 1985-05-01 Beecham Group Plc Process
DE3941657A1 (en) 1989-12-16 1991-06-20 Hoechst Ag METHOD FOR PRODUCING 2-ACYLAMINO-6-HALOGEN PURINE FROM 2,9-DIACYLGUANINE
DE3941658A1 (en) * 1989-12-16 1991-06-20 Hoechst Ag METHOD FOR PRODUCING 2-ACYLAMINO-9-ACYL-6-HALOGEN PURIN
GB9102127D0 (en) * 1991-01-31 1991-03-13 Smithkline Beecham Plc Pharmaceuticals

Also Published As

Publication number Publication date
EP0625154A1 (en) 1994-11-23
NZ246677A (en) 1996-02-27
AU669874B2 (en) 1996-06-27
AU3365493A (en) 1993-09-01
ZA93615B (en) 1993-11-26
GB9201961D0 (en) 1992-03-18
CA2117435A1 (en) 1993-08-05
KR950700299A (en) 1995-01-16
JPH07503246A (en) 1995-04-06
WO1993015075A1 (en) 1993-08-05

Similar Documents

Publication Publication Date Title
ES2140514T3 (en) PROCEDURE FOR THE TREATMENT OF AN ARTICLE AND A NEW AQUEOUS HYDROGEN PEROXIDE SOLUTION.
BR9007059A (en) MANUFACTURE OF 1,1,1,2-TETRAFLUOR ETANO
ES2167908T3 (en) PROCEDURE FOR THE PREPARATION OF HYDROFLUOROCARBONS.
ES2095940T3 (en) PROCEDURE FOR THE PREPARATION OF S-ACIL-GLUTATION DERIVATIVES AND COMPOUNDS OBTAINED BY SUCH PROCEDURE.
MX9300482A (en) PROCESS FOR THE PREPARATION OF 2-AMINO-6-CHLOROPURINE.
FI895389A0 (en) FOERFARANDE FOER FRAMSTAELLNING AV 3,5-DIMETHYL-4-METOXIPYRIDINDERIVAT SAMT NY MELLANPRODUKT HAERFOER.
MX167823B (en) PROCEDURE FOR PREPARING 2-AMINO-6-CHLOROPORIN
IT1177020B (en) PROCESS FOR THE SYNTHESIS OF 2-METHOXY-6-BROMO NAPHTHALENE
DK0569421T3 (en) Pharmaceutical compounds
ES2122149T3 (en) PROCEDURE FOR THE PREPARATION OF 1-CHLORO-1-FLUOROETHANE AND / OR 1,1-DIFLUOROETHANE.
KR950702507A (en) PROCESS FOR THE PREPARATION OF FERRIC CHLORIDE
MX9102537A (en) IMPROVEMENTS IN PROCESS TO REMOVE VINILIDEN CHLORIDE AND OTHER UNSATURATED COMPOUNDS OF 1,1-DICHLORO-1-FLUOROETHANE.
IL65597A (en) Preparation of 1alpha,24,25-trihydroxy-and 24,25-dihydroxy-cholesterol and certain novel intermediates used therein
DE3585632D1 (en) SELECTIVE HALOGENING OF BENZENE DI AND TRIMETHANOLATED COMPOUNDS.
BR8700653A (en) PROCESS FOR DEHYDROCHOLORATION OF HALOGENOALCANS IN THE PRESENCE OF AN INITIATOR BASED ON AN ORGANIC CHLORINE PRODUCT
ES2101938T3 (en) PROCEDURE FOR THE PREPARATION OF 1,1,1,2-TETRAFLUORETHANE.
CS358689A2 (en) Method of 4-chloro-3-alkoxybut-2e-enoic acid's alkyl esters production
ES2080517T3 (en) PROCEDURE FOR THE PREPARATION OF 3,4-DIHALO-1,2-EPOXIBUTANES.
ES2184301T3 (en) PROCEDURE FOR THE PREPARATION OF A DEOXIURIDINE DERIVATIVE.
ES2055006T3 (en) PROCEDURE FOR THE PRODUCTION OF CETO-DIESTERS.
OA06383A (en) Process for the electrolytic preparation of alkali chlorates.
ES2118845T3 (en) PROCESS FOR THE PREPARATION OF TRIMETILALUMINIO BY REACTION OF METALLALUMINIO CHLORIDE WITH SODIUM IN SOLID STATE REACTORS.
BR9815103A (en) Process for the production of hydrofluorocarbons
ES2157395T3 (en) PROCEDURE FOR THE PREPARATION OF DIFLUOROMETHANE.
DE3161432D1 (en) 4-lower hydrocarbyl-3-phenoxypyridine-1-oxides, process for their production, compositions containing them, and their use