KR950700299A - Preparation of 2-amino-6-chlorpurine - Google Patents

Preparation of 2-amino-6-chlorpurine

Info

Publication number
KR950700299A
KR950700299A KR1019940702650A KR19940702650A KR950700299A KR 950700299 A KR950700299 A KR 950700299A KR 1019940702650 A KR1019940702650 A KR 1019940702650A KR 19940702650 A KR19940702650 A KR 19940702650A KR 950700299 A KR950700299 A KR 950700299A
Authority
KR
South Korea
Prior art keywords
amino
acyl groups
guanine
hydrolysis
phase transfer
Prior art date
Application number
KR1019940702650A
Other languages
Korean (ko)
Inventor
로버트 제임스 킬렌 크리스토퍼
Original Assignee
피터 죤 기딩즈
스미스클라인 비참 피엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 피터 죤 기딩즈, 스미스클라인 비참 피엘씨 filed Critical 피터 죤 기딩즈
Publication of KR950700299A publication Critical patent/KR950700299A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 클로라이드 이온을 함유한 상간이동 촉매의 존재하에 구아닌의 2,9-디아실화된 유도체를 클로르화제와 반응시킨 후에, 가수분해시켜 9-아실 그룹 및 2-아실 그룹을 제거함을 포함하여, 2-아미노-6-클로로푸린을 제조하는 방법에 관한 것이다.The present invention comprises reacting a 2,9-diacylated derivative of guanine with a chlorinating agent in the presence of a phase transfer catalyst containing chloride ions, followed by hydrolysis to remove 9-acyl groups and 2-acyl groups, It relates to a method of preparing 2-amino-6-chloropurine.

Description

2-아미노-6-클로로푸린의 제법(Preparation of 2-amino-6-chlorpurine)Preparation of 2-amino-6-chlorpurine

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (6)

클로라이드 이온을 함유하는 상간이동 촉매의 존재하에 구아닌의 2,9-디아실화 유도체를 클로로화제와 반응시킨 후에, 가수분해시켜 9-아실 그룹 및 2-아실 그룹을 제거함을 특징으로 하여, 2-아미노-6-클로로푸린을 제조하는 방법.2-amino, characterized in that a 2,9-diasylated derivative of guanine is reacted with a chloroating agent in the presence of a phase transfer catalyst containing chloride ions, followed by hydrolysis to remove 9-acyl groups and 2-acyl groups. Method for preparing -6-chloropurine. 제1항에 있어서, EP-A-203685호 및 EP-A-433846호에 기재된 바와 같은 방법.The method of claim 1 as described in EP-A-203685 and EP-A-433846. 제2항에 있어서, 클로르화제가 옥시염화인이고 상간이동 촉매가 메틸트리에틸 암모늄 클로라이드인 방법.The process of claim 2 wherein the chlorinating agent is phosphorus oxychloride and the phase transfer catalyst is methyltriethyl ammonium chloride. 제3항에 있어서, 옥시염화인의 양이 2,9-아실화된 구아닌에 대해 2 내지 4당량인 방법.The method of claim 3, wherein the amount of phosphorus oxychloride is 2 to 4 equivalents to 2,9-acylated guanine. 제1항에 있어서, 수성 수산화나트륨이 가수분해시에 염기성 매질로서 사용되는 방법.The process of claim 1 wherein aqueous sodium hydroxide is used as the basic medium in hydrolysis. 제1항에 있어서, 실질적으로 실시예 1에 참조로 기재된 바와 같은 방법.The method of claim 1 substantially as described by reference in Example 1. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940702650A 1992-01-30 1993-01-28 Preparation of 2-amino-6-chlorpurine KR950700299A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB92-01961.1 1992-01-30
GB929201961A GB9201961D0 (en) 1992-01-30 1992-01-30 Pharmaceuticals
PCT/GB1993/000185 WO1993015075A1 (en) 1992-01-30 1993-01-28 Preparation of 2-amino-6-chloropurine

Publications (1)

Publication Number Publication Date
KR950700299A true KR950700299A (en) 1995-01-16

Family

ID=10709516

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940702650A KR950700299A (en) 1992-01-30 1993-01-28 Preparation of 2-amino-6-chlorpurine

Country Status (10)

Country Link
EP (1) EP0625154A1 (en)
JP (1) JPH07503246A (en)
KR (1) KR950700299A (en)
AU (1) AU669874B2 (en)
CA (1) CA2117435A1 (en)
GB (1) GB9201961D0 (en)
MX (1) MX9300482A (en)
NZ (1) NZ246677A (en)
WO (1) WO1993015075A1 (en)
ZA (1) ZA93615B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4231036A1 (en) * 1992-09-17 1994-03-24 Basf Ag Process for the preparation of 2-amino-6-halopurines
JPH07133276A (en) * 1993-09-17 1995-05-23 Jiyuuzen Kagaku Kk Production of 2-acetylamono-6-chloropurine
DE4415196C1 (en) * 1994-04-30 1995-04-27 Boehringer Ingelheim Kg Improved process for the preparation of 2-amino-6-chloropurine and 2-acylamino-6-chloropurines
CA2189088C (en) * 1995-11-09 2005-09-20 Masatoshi Sakai 2-amino-6-chloropurine and method for preparing the same
US7307167B2 (en) 2002-04-04 2007-12-11 Sumitomo Chemical Company, Limited Production method of 2,6-dihalopurine
CN102336755B (en) * 2011-09-30 2013-03-27 浙江工业大学 Chemical synthesis method of 6-chloropurine
CN113214260B (en) * 2021-05-10 2022-04-01 上海凌凯医药科技有限公司 Synthesis method of 2-acetamido-9-acetyl purine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485225D1 (en) 1983-08-18 1991-12-05 Beecham Group Plc ANTIVIRAL GUANINE DERIVATIVES.
EP0182024B1 (en) 1984-09-20 1991-04-03 Beecham Group Plc Purine derivatives and their pharmaceutical use
GB8507606D0 (en) 1985-03-23 1985-05-01 Beecham Group Plc Process
DE3941658A1 (en) * 1989-12-16 1991-06-20 Hoechst Ag METHOD FOR PRODUCING 2-ACYLAMINO-9-ACYL-6-HALOGEN PURIN
DE3941657A1 (en) * 1989-12-16 1991-06-20 Hoechst Ag METHOD FOR PRODUCING 2-ACYLAMINO-6-HALOGEN PURINE FROM 2,9-DIACYLGUANINE
GB9102127D0 (en) * 1991-01-31 1991-03-13 Smithkline Beecham Plc Pharmaceuticals

Also Published As

Publication number Publication date
ZA93615B (en) 1993-11-26
GB9201961D0 (en) 1992-03-18
AU669874B2 (en) 1996-06-27
JPH07503246A (en) 1995-04-06
NZ246677A (en) 1996-02-27
EP0625154A1 (en) 1994-11-23
MX9300482A (en) 1994-07-29
WO1993015075A1 (en) 1993-08-05
CA2117435A1 (en) 1993-08-05
AU3365493A (en) 1993-09-01

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