MX9204051A - ACETYLENE DERIVATIVE THAT HAVE LIPOXIGENASE INHIBITING ACTIVITY - Google Patents

ACETYLENE DERIVATIVE THAT HAVE LIPOXIGENASE INHIBITING ACTIVITY

Info

Publication number
MX9204051A
MX9204051A MX9204051A MX9204051A MX9204051A MX 9204051 A MX9204051 A MX 9204051A MX 9204051 A MX9204051 A MX 9204051A MX 9204051 A MX9204051 A MX 9204051A MX 9204051 A MX9204051 A MX 9204051A
Authority
MX
Mexico
Prior art keywords
lipoxigenase
inhibiting activity
furyl
benzo
thienyl
Prior art date
Application number
MX9204051A
Other languages
Spanish (es)
Inventor
Dee W Brooks
Andrew O Stewart
Daniel J Kerkman
Pramila A Bhatia
Anwer Basha
Jonathan G Martin
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority claimed from PCT/US1991/004911 external-priority patent/WO1992001682A1/en
Publication of MX9204051A publication Critical patent/MX9204051A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compuestos de la estructura (I) en donde p y q son 0 o 1, pero ambos no pueden ser iguales, M es un catión farmacéuticamente aceptable o un grupo metabólicamente desdoblable, B es un enlace de valencia o un grupo alquileno recto o ramificado, R es alquilo, cicloalquilo o -NR1R2, en donde R1 y R2 son hidrógeno, alquilo, cicloalquilo o alcanoilo, y A es, opcionalmente, arilo carbocíclico substituido, furilo, benzo(b)furilo, tienilo o benzo(b)tienilo son inhibidores potentes de las enzimas de lipoxigenasa e inhiben así la biosíntesis de los leucotrienos. Estos compuestos son útiles en el tratamiento o mejora de enfermedades alérgicas e inflamatorias.Compounds of structure (I) where p and q are 0 or 1, but cannot both be the same, M is a pharmaceutically acceptable cation or a metabolically cleavable group, B is a valence bond or a straight or branched alkylene group, R is alkyl, cycloalkyl, or -NR1R2, where R1 and R2 are hydrogen, alkyl, cycloalkyl, or alkanoyl, and A is optionally substituted carbocyclic aryl, furyl, benzo (b) furyl, thienyl, or benzo (b) thienyl are potent inhibitors of lipoxygenase enzymes and thus inhibit leukotriene biosynthesis. These compounds are useful in the treatment or improvement of allergic and inflammatory diseases.

MX9204051A 1991-07-11 1991-07-11 ACETYLENE DERIVATIVE THAT HAVE LIPOXIGENASE INHIBITING ACTIVITY MX9204051A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1991/004911 WO1992001682A1 (en) 1990-07-25 1991-07-11 Acetylene derivatives having lipoxygenase inhibitory activity

Publications (1)

Publication Number Publication Date
MX9204051A true MX9204051A (en) 1993-08-01

Family

ID=22225666

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9204051A MX9204051A (en) 1991-07-11 1991-07-11 ACETYLENE DERIVATIVE THAT HAVE LIPOXIGENASE INHIBITING ACTIVITY

Country Status (1)

Country Link
MX (1) MX9204051A (en)

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees