MX389934B - ADJUVANT COMPOSITION OF A GROWTH FACTOR AND A NEUROPEPTIDE TO ACCELERATE WOUND HEALING AND ORGAN REPITELLIZATION. - Google Patents
ADJUVANT COMPOSITION OF A GROWTH FACTOR AND A NEUROPEPTIDE TO ACCELERATE WOUND HEALING AND ORGAN REPITELLIZATION.Info
- Publication number
- MX389934B MX389934B MX2016016339A MX2016016339A MX389934B MX 389934 B MX389934 B MX 389934B MX 2016016339 A MX2016016339 A MX 2016016339A MX 2016016339 A MX2016016339 A MX 2016016339A MX 389934 B MX389934 B MX 389934B
- Authority
- MX
- Mexico
- Prior art keywords
- growth factor
- organ
- neuropeptide
- wound healing
- repitellization
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 210000000056 organ Anatomy 0.000 title abstract 4
- 239000003102 growth factor Substances 0.000 title abstract 3
- 230000029663 wound healing Effects 0.000 title abstract 2
- 239000002671 adjuvant Substances 0.000 title 1
- 102400001368 Epidermal growth factor Human genes 0.000 abstract 2
- 101800003838 Epidermal growth factor Proteins 0.000 abstract 2
- 102000003797 Neuropeptides Human genes 0.000 abstract 2
- 108090000189 Neuropeptides Proteins 0.000 abstract 2
- 102000050267 Neurotensin Human genes 0.000 abstract 2
- 101800001814 Neurotensin Proteins 0.000 abstract 2
- 229940116977 epidermal growth factor Drugs 0.000 abstract 2
- PCJGZPGTCUMMOT-ISULXFBGSA-N neurotensin Chemical group C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 PCJGZPGTCUMMOT-ISULXFBGSA-N 0.000 abstract 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical group C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 abstract 2
- 230000006866 deterioration Effects 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 206010020718 hyperplasia Diseases 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to the pharmaceutical and biotechnology industry for wound healing and organ re-epithelisation treatments. The advantages of the invention with respect to compositions of the prior art are that, in addition to accelerating the healing process, the composition makes it possible to speed up organ re-epithelisation without generating hyperplasia, thereby improving organ quality following a deterioration. The composition is formed by a growth factor and a neuropeptide. The growth factor is epidermal growth factor, while the neuropeptide is neurotensin. The composition contains epidermal growth factor in a concentration of 0.00001-10 mg/ml and neurotensin in a concentration of 0.00001-10 mg/ml. The combination can have any pharmaceutical form and can be administered by any route of administration.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2016016339A MX389934B (en) | 2016-12-09 | 2016-12-09 | ADJUVANT COMPOSITION OF A GROWTH FACTOR AND A NEUROPEPTIDE TO ACCELERATE WOUND HEALING AND ORGAN REPITELLIZATION. |
| PCT/IB2017/057673 WO2018104874A1 (en) | 2016-12-09 | 2017-12-06 | Adjuvant composition comprising a growth factor and a neuropeptide for accelerating wound healing and organ re-epithelisation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2016016339A MX389934B (en) | 2016-12-09 | 2016-12-09 | ADJUVANT COMPOSITION OF A GROWTH FACTOR AND A NEUROPEPTIDE TO ACCELERATE WOUND HEALING AND ORGAN REPITELLIZATION. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016016339A MX2016016339A (en) | 2018-06-08 |
| MX389934B true MX389934B (en) | 2025-03-20 |
Family
ID=62491777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016016339A MX389934B (en) | 2016-12-09 | 2016-12-09 | ADJUVANT COMPOSITION OF A GROWTH FACTOR AND A NEUROPEPTIDE TO ACCELERATE WOUND HEALING AND ORGAN REPITELLIZATION. |
Country Status (2)
| Country | Link |
|---|---|
| MX (1) | MX389934B (en) |
| WO (1) | WO2018104874A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20211569T1 (en) | 2016-06-07 | 2022-01-21 | Modernatx, Inc. | Modified rna encoding vegf-a polypeptides, formulations, and uses relating thereto |
| CA3080592A1 (en) | 2017-10-31 | 2019-05-09 | Modernatx, Inc. | Lipid nanoparticles for delivering modified rna encoding a vegf-a polypeptide |
| JP2022532078A (en) * | 2019-05-08 | 2022-07-13 | アストラゼネカ アクチボラグ | Compositions for skin and wounds and methods of their use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE253374T1 (en) * | 1998-03-07 | 2003-11-15 | Dae Woong Pharma | TOPICAL COMPOSITION CONTAINING HUMAN EPIDERMAL GROWTH FACTOR |
| CU23043A1 (en) * | 2001-12-20 | 2005-05-20 | Ct Ingenieria Genetica Biotech | PHARMACEUTICAL COMPOSITION CONTAINING EPIDROMIC GROWTH FACTOR (EGF) FOR THE PREVENTION OF AMBASSATION OF DIABETIC FOOT. |
| US7776815B2 (en) * | 2004-02-24 | 2010-08-17 | Wisconsin Alumni Research Foundation | Use of neuropeptides for ligament healing |
| CU23388B6 (en) * | 2006-01-31 | 2009-07-16 | Ct Ingenieria Genetica Biotech | PHARMACEUTICAL COMPOSITION OF MICROSPHERES TO PREVENT AMPUTATION OF THE DIABETIC FOOT |
-
2016
- 2016-12-09 MX MX2016016339A patent/MX389934B/en unknown
-
2017
- 2017-12-06 WO PCT/IB2017/057673 patent/WO2018104874A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| MX2016016339A (en) | 2018-06-08 |
| WO2018104874A1 (en) | 2018-06-14 |
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