MX386201B - Ligadores de brazo colgante corto para nucleótidos en aplicaciones de secuenciación. - Google Patents

Ligadores de brazo colgante corto para nucleótidos en aplicaciones de secuenciación.

Info

Publication number
MX386201B
MX386201B MX2019012373A MX2019012373A MX386201B MX 386201 B MX386201 B MX 386201B MX 2019012373 A MX2019012373 A MX 2019012373A MX 2019012373 A MX2019012373 A MX 2019012373A MX 386201 B MX386201 B MX 386201B
Authority
MX
Mexico
Prior art keywords
ligators
nucleotides
sequencing applications
compounds
arm
Prior art date
Application number
MX2019012373A
Other languages
English (en)
Inventor
Antoine Francais
Elena Cressina
Xiaohai Liu
Original Assignee
Illumina Cambridge Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Cambridge Ltd filed Critical Illumina Cambridge Ltd
Publication of MX386201B publication Critical patent/MX386201B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Chemical Kinetics & Catalysis (AREA)

Abstract

La presente invención se refiere a nuevos compuestos de nucleótido y oligonucleótido y su uso en aplicaciones de secuenciación de ácido nucleico.
MX2019012373A 2017-07-12 2018-07-12 Ligadores de brazo colgante corto para nucleótidos en aplicaciones de secuenciación. MX386201B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1711219.4A GB201711219D0 (en) 2017-07-12 2017-07-12 Short pendant arm linkers for nucleotides in sequencing applications
PCT/EP2018/069030 WO2019012080A1 (en) 2017-07-12 2018-07-12 SHORT ARM LINKS FOR NUCLEOTIDES IN SEQUENCING APPLICATIONS

Publications (1)

Publication Number Publication Date
MX386201B true MX386201B (es) 2025-03-18

Family

ID=59676794

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019012373A MX386201B (es) 2017-07-12 2018-07-12 Ligadores de brazo colgante corto para nucleótidos en aplicaciones de secuenciación.
MX2021011019A MX2021011019A (es) 2017-07-12 2019-10-16 Ligadores de brazo colgante corto para nucleotidos en aplicaciones de secuenciacion.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021011019A MX2021011019A (es) 2017-07-12 2019-10-16 Ligadores de brazo colgante corto para nucleotidos en aplicaciones de secuenciacion.

Country Status (14)

Country Link
US (4) US10526648B2 (es)
EP (1) EP3652191A1 (es)
JP (1) JP7041695B2 (es)
KR (2) KR20220119182A (es)
CN (1) CN111094315B (es)
AU (1) AU2018298847B2 (es)
CA (1) CA3060152A1 (es)
GB (1) GB201711219D0 (es)
IL (1) IL271428B1 (es)
MX (2) MX386201B (es)
MY (1) MY196912A (es)
RU (1) RU2019137083A (es)
WO (1) WO2019012080A1 (es)
ZA (1) ZA201906836B (es)

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GB201711219D0 (en) 2017-07-12 2017-08-23 Illumina Cambridge Ltd Short pendant arm linkers for nucleotides in sequencing applications
CA3103739A1 (en) 2018-12-05 2020-06-11 Illumina, Inc. Polymerases, compositions, and methods of use
CN113710686A (zh) 2019-02-19 2021-11-26 阿尔缇玛基因组学公司 用于光学检测和测序的接头和方法
MY209343A (en) 2019-03-01 2025-07-03 Illumina Cambridge Ltd Exocyclic amine substituted coumarin compounds and uses as fluorescent labels
KR102865446B1 (ko) 2019-03-01 2025-09-29 일루미나 케임브리지 리미티드 삼차 아민 치환된 쿠마린 화합물 및 형광 표지로서의 이의 용도
JP2023510454A (ja) 2019-11-27 2023-03-14 イルミナ ケンブリッジ リミテッド シクロオクタテトラエンを含有する色素及び組成物
EP4317168A4 (en) * 2021-04-01 2025-08-27 Bgi Shenzhen NUCLEOTIDE ANALOGUE FOR SEQUENCING
US12077789B2 (en) 2021-08-14 2024-09-03 Illumina, Inc. Polymerases, compositions, and methods of use
CN116239493B (zh) * 2023-03-15 2024-07-26 杭州易速微控基因技术有限公司 一种Linker类化合物的合成方法

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Also Published As

Publication number Publication date
US20200131569A1 (en) 2020-04-30
WO2019012080A1 (en) 2019-01-17
US20190017111A1 (en) 2019-01-17
AU2018298847A1 (en) 2019-11-07
CN111094315A (zh) 2020-05-01
RU2019137083A3 (es) 2021-06-18
US12071662B2 (en) 2024-08-27
JP7041695B2 (ja) 2022-03-24
MY196912A (en) 2023-05-10
BR112019027614A2 (pt) 2020-07-07
RU2019137083A (ru) 2021-06-18
US20230348968A1 (en) 2023-11-02
US11001888B2 (en) 2021-05-11
US11655502B2 (en) 2023-05-23
AU2018298847B2 (en) 2021-02-11
KR20220119182A (ko) 2022-08-26
MX2021011019A (es) 2021-10-14
GB201711219D0 (en) 2017-08-23
NZ759350A (en) 2023-10-27
CA3060152A1 (en) 2019-01-17
JP2020527131A (ja) 2020-09-03
US20210230687A1 (en) 2021-07-29
EP3652191A1 (en) 2020-05-20
IL271428B1 (en) 2026-03-01
IL271428A (en) 2020-01-30
ZA201906836B (en) 2023-04-26
US10526648B2 (en) 2020-01-07
CN111094315B (zh) 2024-04-09
KR20200023282A (ko) 2020-03-04

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