MX368707B - Compuestos para usarse para inhibir c-kit cinasa fosforilada constitutivamente activa. - Google Patents
Compuestos para usarse para inhibir c-kit cinasa fosforilada constitutivamente activa.Info
- Publication number
- MX368707B MX368707B MX2013010840A MX2013010840A MX368707B MX 368707 B MX368707 B MX 368707B MX 2013010840 A MX2013010840 A MX 2013010840A MX 2013010840 A MX2013010840 A MX 2013010840A MX 368707 B MX368707 B MX 368707B
- Authority
- MX
- Mexico
- Prior art keywords
- kit
- mutant
- compound
- kinase activity
- present
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 title 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261705838P | 2012-09-26 | 2012-09-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013010840A MX2013010840A (es) | 2015-04-27 |
| MX368707B true MX368707B (es) | 2019-10-11 |
Family
ID=50295125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013010840A MX368707B (es) | 2012-09-26 | 2013-09-20 | Compuestos para usarse para inhibir c-kit cinasa fosforilada constitutivamente activa. |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9480683B2 (OSRAM) |
| JP (1) | JP6042157B2 (OSRAM) |
| KR (2) | KR20140040594A (OSRAM) |
| CN (2) | CN103655563A (OSRAM) |
| AU (1) | AU2013204841B2 (OSRAM) |
| CA (1) | CA2812258C (OSRAM) |
| MX (1) | MX368707B (OSRAM) |
| TW (1) | TWI599356B (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI569799B (zh) | 2012-09-21 | 2017-02-11 | 安羅格製藥股份有限公司 | 抑制組成型活性磷酸化ｆｌｔ３激酶的方法 |
| KR20140040594A (ko) | 2012-09-26 | 2014-04-03 | 아로그 파마슈티칼스, 엘엘씨 | 돌연변이체 c-kit의 억제 방법 |
| US10835525B2 (en) | 2012-09-26 | 2020-11-17 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| US11642340B2 (en) * | 2012-09-26 | 2023-05-09 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| BR112015016282A2 (pt) | 2013-01-07 | 2017-07-11 | Arog Pharmaceuticals Inc | crenolanibe para tratamento de distúrbios proliferativos de flt3 mutado |
| ES2831084T3 (es) | 2016-06-10 | 2021-06-07 | Vitae Pharmaceuticals Inc | Inhibidores de la interacción menina-MLL |
| WO2018014519A1 (zh) * | 2016-07-18 | 2018-01-25 | 北京雅康博生物科技有限公司 | 用于检测c-kit基因突变的引物、探针及试剂盒 |
| HK1257195A1 (zh) | 2016-11-02 | 2019-10-18 | 安罗格制药有限责任公司 | 用於治疗flt3突变型增殖性疾患相关突变的克莱拉尼 |
| CN107382983B (zh) * | 2017-08-24 | 2020-08-07 | 扬州市三药制药有限公司 | 一种治疗白血病药物的合成方法 |
| DE102019204219A1 (de) * | 2019-03-27 | 2020-10-01 | Robert Bosch Gmbh | Verfahren zur Diagnose von Abgassensoren |
| US11471451B2 (en) * | 2019-08-19 | 2022-10-18 | Arog Pharmaceuticals, Inc. | Uses of crenolanib |
| CN113855671A (zh) * | 2020-05-26 | 2021-12-31 | 江苏恒瑞医药股份有限公司 | 法米替尼在制备用于治疗c-KIT或PDGFRA突变的肿瘤的药物中的用途 |
| WO2022019998A1 (en) | 2020-07-20 | 2022-01-27 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| CA3186319A1 (en) * | 2020-07-20 | 2022-01-27 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| WO2022090547A1 (en) | 2020-10-30 | 2022-05-05 | Dsm Ip Assets B.V. | Production of carotenoids by fermentation |
| US11969420B2 (en) | 2020-10-30 | 2024-04-30 | Arog Pharmaceuticals, Inc. | Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders |
| KR20230145381A (ko) * | 2021-02-09 | 2023-10-17 | 재스퍼 테라퓨틱스 인코포레이티드 | 변형된 줄기 세포 조성물 및 사용 방법 |
| CN113683594B (zh) * | 2021-09-07 | 2022-12-27 | 曲靖师范学院 | 一种喹啉-苯并咪唑盐类化合物及其合成方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5990146A (en) | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
| EP1017682A4 (en) | 1997-09-26 | 2000-11-08 | Merck & Co Inc | NEW ANGIOGENESIS INHIBITORS |
| UA75055C2 (uk) | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі |
| PA8580301A1 (es) * | 2002-08-28 | 2005-05-24 | Pfizer Prod Inc | Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos |
| CN100404530C (zh) | 2003-06-24 | 2008-07-23 | 辉瑞产品公司 | 1-[2-(苯并咪唑-1-基)喹啉-8-基]哌啶-4-基胺衍生物的制备方法 |
| US20130230511A1 (en) * | 2012-02-03 | 2013-09-05 | Board Of Regents, The University Of Texas System | Biomarkers for response to tyrosine kinase pathway inhibitors in cancer |
| TWI569799B (zh) | 2012-09-21 | 2017-02-11 | 安羅格製藥股份有限公司 | 抑制組成型活性磷酸化ｆｌｔ３激酶的方法 |
| KR20140040594A (ko) | 2012-09-26 | 2014-04-03 | 아로그 파마슈티칼스, 엘엘씨 | 돌연변이체 c-kit의 억제 방법 |
-
2012
- 2012-09-28 KR KR1020120109114A patent/KR20140040594A/ko not_active Ceased
- 2012-09-28 JP JP2012217361A patent/JP6042157B2/ja not_active Expired - Fee Related
- 2012-09-28 TW TW101135903A patent/TWI599356B/zh not_active IP Right Cessation
- 2012-09-29 CN CN201210378267.5A patent/CN103655563A/zh active Pending
- 2012-09-29 CN CN201810781649.XA patent/CN109010340A/zh active Pending
-
2013
- 2013-04-10 CA CA2812258A patent/CA2812258C/en active Active
- 2013-04-12 AU AU2013204841A patent/AU2013204841B2/en not_active Ceased
- 2013-09-13 US US14/026,886 patent/US9480683B2/en not_active Expired - Fee Related
- 2013-09-20 MX MX2013010840A patent/MX368707B/es active IP Right Grant
-
2016
- 2016-09-02 US US15/255,912 patent/US9889127B2/en active Active
-
2017
- 2017-10-17 KR KR1020170134689A patent/KR101886006B1/ko not_active Expired - Fee Related
-
2018
- 2018-01-04 US US15/862,011 patent/US10251877B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20140088147A1 (en) | 2014-03-27 |
| CN109010340A (zh) | 2018-12-18 |
| TWI599356B (zh) | 2017-09-21 |
| US10251877B2 (en) | 2019-04-09 |
| CA2812258C (en) | 2016-12-13 |
| JP6042157B2 (ja) | 2016-12-14 |
| KR20140040594A (ko) | 2014-04-03 |
| MX2013010840A (es) | 2015-04-27 |
| AU2013204841A1 (en) | 2014-04-10 |
| CN103655563A (zh) | 2014-03-26 |
| US9889127B2 (en) | 2018-02-13 |
| US9480683B2 (en) | 2016-11-01 |
| JP2014065696A (ja) | 2014-04-17 |
| US20160367545A1 (en) | 2016-12-22 |
| AU2013204841B2 (en) | 2016-04-28 |
| CA2812258A1 (en) | 2014-03-26 |
| KR20170119659A (ko) | 2017-10-27 |
| US20180125839A1 (en) | 2018-05-10 |
| KR101886006B1 (ko) | 2018-08-06 |
| TW201417815A (zh) | 2014-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |