MX364619B - Process for the obtention of praziquantel enantiomers and 4' ûhydroxylated derivatives thereof. - Google Patents
Process for the obtention of praziquantel enantiomers and 4' ûhydroxylated derivatives thereof.Info
- Publication number
- MX364619B MX364619B MX2012009920A MX2012009920A MX364619B MX 364619 B MX364619 B MX 364619B MX 2012009920 A MX2012009920 A MX 2012009920A MX 2012009920 A MX2012009920 A MX 2012009920A MX 364619 B MX364619 B MX 364619B
- Authority
- MX
- Mexico
- Prior art keywords
- praziquantel
- ûhydroxylated
- obtention
- enantiomers
- derivatives
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a novel process for easily and affordably obtaining (R)-(-)-praziquantel, (S)-(+)-praziquantel, as well as a process for the synthesis of the main hydroxylated metabolites thereof. The process of the present invention involves the resolution of the praziquanamine 12, 3, 6, 7 11b-hexahydro-4h-pyrazine [2,1-a]isoquinoline-4-ona, with (S)-(+)-naproxen as a resolution agent; while the synthesis of the stereoisomers cis and trans-4’-hydroxylated of (R)-(-)-praziquantel is performed from the mixture of cis and trans-4’hydroxy cyclohexanecarboxylate of ethyl and the (R)-(-)-praziquinamine.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2012009920A MX364619B (en) | 2012-08-27 | 2012-08-27 | Process for the obtention of praziquantel enantiomers and 4' ûhydroxylated derivatives thereof. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2012009920A MX364619B (en) | 2012-08-27 | 2012-08-27 | Process for the obtention of praziquantel enantiomers and 4' ûhydroxylated derivatives thereof. |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012009920A MX2012009920A (en) | 2014-02-26 |
MX364619B true MX364619B (en) | 2019-03-15 |
Family
ID=50732410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012009920A MX364619B (en) | 2012-08-27 | 2012-08-27 | Process for the obtention of praziquantel enantiomers and 4' ûhydroxylated derivatives thereof. |
Country Status (1)
Country | Link |
---|---|
MX (1) | MX364619B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105061424B (en) * | 2015-08-31 | 2016-10-05 | 上海海洋大学 | A kind of synthetic method of praziquantel metabolite |
CN107151246B (en) * | 2016-03-04 | 2019-01-22 | 苏州同力生物医药有限公司 | The preparation method of one kind (R)-praziquantel amine salt and levo-praziquantel |
CN105753865A (en) * | 2016-03-23 | 2016-07-13 | 江苏诚信药业有限公司 | Process for synthesizing levopraziquantel |
-
2012
- 2012-08-27 MX MX2012009920A patent/MX364619B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
MX2012009920A (en) | 2014-02-26 |
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