MX364619B - Process for the obtention of praziquantel enantiomers and 4' ûhydroxylated derivatives thereof. - Google Patents

Process for the obtention of praziquantel enantiomers and 4' ûhydroxylated derivatives thereof.

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Publication number
MX364619B
MX364619B MX2012009920A MX2012009920A MX364619B MX 364619 B MX364619 B MX 364619B MX 2012009920 A MX2012009920 A MX 2012009920A MX 2012009920 A MX2012009920 A MX 2012009920A MX 364619 B MX364619 B MX 364619B
Authority
MX
Mexico
Prior art keywords
praziquantel
ûhydroxylated
obtention
enantiomers
derivatives
Prior art date
Application number
MX2012009920A
Other languages
Spanish (es)
Other versions
MX2012009920A (en
Inventor
Cedillo Cruz Alberto
Isabel Aguilar Laurents María
Helene Jung Cook Helgi
Original Assignee
Univ Mexico Nac Autonoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Mexico Nac Autonoma filed Critical Univ Mexico Nac Autonoma
Priority to MX2012009920A priority Critical patent/MX364619B/en
Publication of MX2012009920A publication Critical patent/MX2012009920A/en
Publication of MX364619B publication Critical patent/MX364619B/en

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Abstract

The present invention provides a novel process for easily and affordably obtaining (R)-(-)-praziquantel, (S)-(+)-praziquantel, as well as a process for the synthesis of the main hydroxylated metabolites thereof. The process of the present invention involves the resolution of the praziquanamine 12, 3, 6, 7 11b-hexahydro-4h-pyrazine [2,1-a]isoquinoline-4-ona, with (S)-(+)-naproxen as a resolution agent; while the synthesis of the stereoisomers cis and trans-4’-hydroxylated of (R)-(-)-praziquantel is performed from the mixture of cis and trans-4’hydroxy cyclohexanecarboxylate of ethyl and the (R)-(-)-praziquinamine.
MX2012009920A 2012-08-27 2012-08-27 Process for the obtention of praziquantel enantiomers and 4' ûhydroxylated derivatives thereof. MX364619B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MX2012009920A MX364619B (en) 2012-08-27 2012-08-27 Process for the obtention of praziquantel enantiomers and 4' ûhydroxylated derivatives thereof.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MX2012009920A MX364619B (en) 2012-08-27 2012-08-27 Process for the obtention of praziquantel enantiomers and 4' ûhydroxylated derivatives thereof.

Publications (2)

Publication Number Publication Date
MX2012009920A MX2012009920A (en) 2014-02-26
MX364619B true MX364619B (en) 2019-03-15

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ID=50732410

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012009920A MX364619B (en) 2012-08-27 2012-08-27 Process for the obtention of praziquantel enantiomers and 4' ûhydroxylated derivatives thereof.

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MX (1) MX364619B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105061424B (en) * 2015-08-31 2016-10-05 上海海洋大学 A kind of synthetic method of praziquantel metabolite
CN107151246B (en) * 2016-03-04 2019-01-22 苏州同力生物医药有限公司 The preparation method of one kind (R)-praziquantel amine salt and levo-praziquantel
CN105753865A (en) * 2016-03-23 2016-07-13 江苏诚信药业有限公司 Process for synthesizing levopraziquantel

Also Published As

Publication number Publication date
MX2012009920A (en) 2014-02-26

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