MX361113B - Method for the isolation and synthesis of 3-(1', 1'- dimethylallyl)-herniarin, as well as (e)-3-(1',1'-dimethyl-3'nit ro-allyl-herniarin, from casimiroa pubescens, and use thereof as an antidepressant. - Google Patents
Method for the isolation and synthesis of 3-(1', 1'- dimethylallyl)-herniarin, as well as (e)-3-(1',1'-dimethyl-3'nit ro-allyl-herniarin, from casimiroa pubescens, and use thereof as an antidepressant.Info
- Publication number
- MX361113B MX361113B MX2014007297A MX2014007297A MX361113B MX 361113 B MX361113 B MX 361113B MX 2014007297 A MX2014007297 A MX 2014007297A MX 2014007297 A MX2014007297 A MX 2014007297A MX 361113 B MX361113 B MX 361113B
- Authority
- MX
- Mexico
- Prior art keywords
- herniarin
- dimethylallyl
- allyl
- dimethyl
- isolation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
- C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring
- C07D311/50—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring with elements other than carbon and hydrogen in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to the compounds 3-(1',1' -dimethylallyl)-herniarin (1) y 3- (1,1'-dimethyl-3' nitro allyl-herniarin] (3) (NHR) derived from coumarin, which have excellent antidepressant activity. The compound 3- (1,1'-dimethyl-3' nitro allyl-herniarin] (3) (NHR) is synthesised by means of a nitration reaction of the compound 3-(1',1'-dimethylallyl)-herniarin. The present invention also relates to the method for the isolation and synthesis of the compound 3 -(1',1'-dimethylallyl)-herniarin.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2014007297A MX361113B (en) | 2014-06-17 | 2014-06-17 | Method for the isolation and synthesis of 3-(1', 1'- dimethylallyl)-herniarin, as well as (e)-3-(1',1'-dimethyl-3'nit ro-allyl-herniarin, from casimiroa pubescens, and use thereof as an antidepressant. |
PCT/MX2015/000093 WO2015194928A1 (en) | 2014-06-17 | 2015-06-10 | Method for the isolation and synthesis of 3-(1´, 1´- dimethylallyl)-herniarin, as well as (e)-3-(1´,1´-dimethyl-3´nitro-allyl-herniarin, from casimiroa pubescens, and use thereof as an antidepressant |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2014007297A MX361113B (en) | 2014-06-17 | 2014-06-17 | Method for the isolation and synthesis of 3-(1', 1'- dimethylallyl)-herniarin, as well as (e)-3-(1',1'-dimethyl-3'nit ro-allyl-herniarin, from casimiroa pubescens, and use thereof as an antidepressant. |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014007297A MX2014007297A (en) | 2015-12-17 |
MX361113B true MX361113B (en) | 2018-11-20 |
Family
ID=54935826
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014007297A MX361113B (en) | 2014-06-17 | 2014-06-17 | Method for the isolation and synthesis of 3-(1', 1'- dimethylallyl)-herniarin, as well as (e)-3-(1',1'-dimethyl-3'nit ro-allyl-herniarin, from casimiroa pubescens, and use thereof as an antidepressant. |
Country Status (2)
Country | Link |
---|---|
MX (1) | MX361113B (en) |
WO (1) | WO2015194928A1 (en) |
-
2014
- 2014-06-17 MX MX2014007297A patent/MX361113B/en active IP Right Grant
-
2015
- 2015-06-10 WO PCT/MX2015/000093 patent/WO2015194928A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2015194928A1 (en) | 2015-12-23 |
MX2014007297A (en) | 2015-12-17 |
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Legal Events
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FG | Grant or registration |