MX2014007297A - Method for the isolation and synthesis of 3-(1', 1'- dimethylallyl)-herniarin, as well as (e)-3-(1',1'-dimethyl-3'nit ro-allyl-herniarin, from casimiroa pubescens, and use thereof as an antidepressant. - Google Patents

Method for the isolation and synthesis of 3-(1', 1'- dimethylallyl)-herniarin, as well as (e)-3-(1',1'-dimethyl-3'nit ro-allyl-herniarin, from casimiroa pubescens, and use thereof as an antidepressant.

Info

Publication number
MX2014007297A
MX2014007297A MX2014007297A MX2014007297A MX2014007297A MX 2014007297 A MX2014007297 A MX 2014007297A MX 2014007297 A MX2014007297 A MX 2014007297A MX 2014007297 A MX2014007297 A MX 2014007297A MX 2014007297 A MX2014007297 A MX 2014007297A
Authority
MX
Mexico
Prior art keywords
herniarin
dimethylallyl
allyl
dimethyl
isolation
Prior art date
Application number
MX2014007297A
Other languages
Spanish (es)
Other versions
MX361113B (en
Inventor
Mariano Martínez Vázquez
Rosa Estrada Reyes
Denisse Ubaldo Suárez
Roberto De La Rosa Sierra
Original Assignee
Univ Nac Autónoma De México
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nac Autónoma De México filed Critical Univ Nac Autónoma De México
Priority to MX2014007297A priority Critical patent/MX361113B/en
Priority to PCT/MX2015/000093 priority patent/WO2015194928A1/en
Publication of MX2014007297A publication Critical patent/MX2014007297A/en
Publication of MX361113B publication Critical patent/MX361113B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
    • C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring
    • C07D311/50—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring with elements other than carbon and hydrogen in position 3

Abstract

The invention relates to the compounds 3-(1',1' -dimethylallyl)-herniarin (1) y 3- (1,1'-dimethyl-3' nitro allyl-herniarin] (3) (NHR) derived from coumarin, which have excellent antidepressant activity. The compound 3- (1,1'-dimethyl-3' nitro allyl-herniarin] (3) (NHR) is synthesised by means of a nitration reaction of the compound 3-(1',1'-dimethylallyl)-herniarin. The present invention also relates to the method for the isolation and synthesis of the compound 3 -(1',1'-dimethylallyl)-herniarin.
MX2014007297A 2014-06-17 2014-06-17 Method for the isolation and synthesis of 3-(1', 1'- dimethylallyl)-herniarin, as well as (e)-3-(1',1'-dimethyl-3'nit ro-allyl-herniarin, from casimiroa pubescens, and use thereof as an antidepressant. MX361113B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
MX2014007297A MX361113B (en) 2014-06-17 2014-06-17 Method for the isolation and synthesis of 3-(1', 1'- dimethylallyl)-herniarin, as well as (e)-3-(1',1'-dimethyl-3'nit ro-allyl-herniarin, from casimiroa pubescens, and use thereof as an antidepressant.
PCT/MX2015/000093 WO2015194928A1 (en) 2014-06-17 2015-06-10 Method for the isolation and synthesis of 3-(1´, 1´- dimethylallyl)-herniarin, as well as (e)-3-(1´,1´-dimethyl-3´nitro-allyl-herniarin, from casimiroa pubescens, and use thereof as an antidepressant

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MX2014007297A MX361113B (en) 2014-06-17 2014-06-17 Method for the isolation and synthesis of 3-(1', 1'- dimethylallyl)-herniarin, as well as (e)-3-(1',1'-dimethyl-3'nit ro-allyl-herniarin, from casimiroa pubescens, and use thereof as an antidepressant.

Publications (2)

Publication Number Publication Date
MX2014007297A true MX2014007297A (en) 2015-12-17
MX361113B MX361113B (en) 2018-11-20

Family

ID=54935826

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014007297A MX361113B (en) 2014-06-17 2014-06-17 Method for the isolation and synthesis of 3-(1', 1'- dimethylallyl)-herniarin, as well as (e)-3-(1',1'-dimethyl-3'nit ro-allyl-herniarin, from casimiroa pubescens, and use thereof as an antidepressant.

Country Status (2)

Country Link
MX (1) MX361113B (en)
WO (1) WO2015194928A1 (en)

Also Published As

Publication number Publication date
WO2015194928A1 (en) 2015-12-23
MX361113B (en) 2018-11-20

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