MX350390B - Formulations of deoxycholic acid and salts thereof. - Google Patents
Formulations of deoxycholic acid and salts thereof.Info
- Publication number
- MX350390B MX350390B MX2014001495A MX2014001495A MX350390B MX 350390 B MX350390 B MX 350390B MX 2014001495 A MX2014001495 A MX 2014001495A MX 2014001495 A MX2014001495 A MX 2014001495A MX 350390 B MX350390 B MX 350390B
- Authority
- MX
- Mexico
- Prior art keywords
- deoxycholic acid
- formulations
- salts
- composition
- salt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2011/048806 WO2013028177A1 (en) | 2011-08-23 | 2011-08-23 | Formulations of deoxycholic acid and salts thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014001495A MX2014001495A (en) | 2014-04-25 |
MX350390B true MX350390B (en) | 2017-09-06 |
Family
ID=45569726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014001495A MX350390B (en) | 2011-08-23 | 2011-08-23 | Formulations of deoxycholic acid and salts thereof. |
Country Status (18)
Country | Link |
---|---|
JP (1) | JP5919597B2 (en) |
KR (5) | KR101919269B1 (en) |
CN (3) | CN108619089A (en) |
AU (3) | AU2011375432B2 (en) |
BR (1) | BR112014000547B1 (en) |
CA (1) | CA2842177C (en) |
CR (1) | CR20140053A (en) |
EA (1) | EA029305B1 (en) |
IL (1) | IL230547A (en) |
IN (1) | IN2014CN02188A (en) |
MX (1) | MX350390B (en) |
MY (1) | MY184277A (en) |
NZ (1) | NZ620040A (en) |
PH (1) | PH12016501175A1 (en) |
SG (1) | SG2014013205A (en) |
UA (1) | UA113522C2 (en) |
WO (1) | WO2013028177A1 (en) |
ZA (1) | ZA201401027B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
US20170119794A1 (en) * | 2015-11-04 | 2017-05-04 | Kythera Biopharmaceuticals, Inc. | Treatments of accumulated fat with deoxycholic acid and salts thereof |
US20180078621A1 (en) * | 2016-09-22 | 2018-03-22 | Kyoung Lack Lee | Composition for hypotonic lipolysis and manufacturing method thereof |
KR101841193B1 (en) * | 2016-09-22 | 2018-03-22 | 이경락 | Composition for hypotonic lipolysis and manufacturing method thereof |
JP7042531B2 (en) * | 2018-04-16 | 2022-03-28 | ペンミックス リミテッド | Pharmaceutical composition containing deoxycholic acid |
KR102172439B1 (en) | 2018-12-05 | 2020-10-30 | 송미희 | Composition for lipolysis and injection composition comprising the same |
KR102064864B1 (en) | 2019-02-08 | 2020-01-10 | (주)제테마 | Topical injectable composition |
KR102111346B1 (en) * | 2019-08-20 | 2020-05-22 | 아영창 | Aqueous composition with sodium deoxycholate having improved stability against precipitation |
KR20220026068A (en) | 2020-08-25 | 2022-03-04 | 강명범 | Composition for lipolysis and injection composition comprising the same |
CN116617160A (en) * | 2023-07-25 | 2023-08-22 | 山东则正医药技术有限公司 | Aqueous suspension, preparation method, freeze-dried powder, application and fat reduction injection |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2754709B1 (en) | 1996-10-23 | 1999-03-05 | Sanofi Sa | COSMETIC COMPOSITION CONTAINING AN ANTAGONIST OF GAMMA NEUROPEPTIDE RECEPTORS AND ALPHA 2 ANTAGONISTS THAT MAY BE INCORPORATED IN SUCH A COMPOSITION |
KR100524358B1 (en) * | 1998-07-24 | 2005-10-26 | 유서홍 | Preparation of aqueous clear solution dosage forms with bile acids |
US6417179B1 (en) | 1998-10-13 | 2002-07-09 | Craig G. Burkhart | Ear wax solution |
US20050048126A1 (en) * | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
DE10361067A1 (en) * | 2003-12-22 | 2005-07-14 | Aventis Pharma Deutschland Gmbh | Medicinal lipolysis of fat accumulations |
US7754230B2 (en) * | 2004-05-19 | 2010-07-13 | The Regents Of The University Of California | Methods and related compositions for reduction of fat |
US7622130B2 (en) * | 2004-05-19 | 2009-11-24 | Los Angeles Biomedical Research Institute at Harbor UCLA-Medical Center | Methods and compositions for the non-surgical removal of fat |
US20060127468A1 (en) * | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
AU2006255097B2 (en) | 2005-06-06 | 2012-02-09 | Georgetown University | Compositions and methods for lipo modeling |
TW201011755A (en) | 2008-09-10 | 2010-03-16 | Skymedi Corp | Flash memory system and its data recovery method |
JP5420946B2 (en) * | 2009-03-23 | 2014-02-19 | 富士フイルム株式会社 | Minoxidil aqueous composition containing bile acids |
EP2645099A1 (en) | 2012-03-30 | 2013-10-02 | Phares Pharmaceutical Research N.V. | Biorelevant compositions |
-
2011
- 2011-08-23 IN IN2188CHN2014 patent/IN2014CN02188A/en unknown
- 2011-08-23 CA CA2842177A patent/CA2842177C/en active Active
- 2011-08-23 SG SG2014013205A patent/SG2014013205A/en unknown
- 2011-08-23 KR KR1020177016779A patent/KR101919269B1/en active IP Right Grant
- 2011-08-23 CN CN201810400642.9A patent/CN108619089A/en active Pending
- 2011-08-23 AU AU2011375432A patent/AU2011375432B2/en active Active
- 2011-08-23 CN CN201810403291.7A patent/CN108743522A/en active Pending
- 2011-08-23 EA EA201490175A patent/EA029305B1/en unknown
- 2011-08-23 MX MX2014001495A patent/MX350390B/en active IP Right Grant
- 2011-08-23 UA UAA201400641A patent/UA113522C2/en unknown
- 2011-08-23 BR BR112014000547-8A patent/BR112014000547B1/en active IP Right Grant
- 2011-08-23 KR KR1020197030233A patent/KR102073536B1/en active IP Right Grant
- 2011-08-23 MY MYPI2014000197A patent/MY184277A/en unknown
- 2011-08-23 NZ NZ620040A patent/NZ620040A/en unknown
- 2011-08-23 KR KR1020187032491A patent/KR102034606B1/en active IP Right Grant
- 2011-08-23 KR KR1020207002722A patent/KR20200013103A/en not_active Application Discontinuation
- 2011-08-23 CN CN201180072842.2A patent/CN103826608A/en active Pending
- 2011-08-23 WO PCT/US2011/048806 patent/WO2013028177A1/en active Application Filing
- 2011-08-23 KR KR1020147006855A patent/KR101751585B1/en active IP Right Review Request
- 2011-08-23 JP JP2014527128A patent/JP5919597B2/en active Active
-
2014
- 2014-01-20 IL IL230547A patent/IL230547A/en active IP Right Grant
- 2014-01-30 CR CR20140053A patent/CR20140053A/en unknown
- 2014-02-10 ZA ZA2014/01027A patent/ZA201401027B/en unknown
-
2016
- 2016-04-27 AU AU2016202661A patent/AU2016202661B2/en active Active
- 2016-06-16 PH PH12016501175A patent/PH12016501175A1/en unknown
-
2018
- 2018-04-23 AU AU2018202807A patent/AU2018202807B2/en active Active
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Legal Events
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