MX3493E - Procedimiento para la preparacion de una composicion de materia a base de un alcaloide de cornezuelo de centeno, papaverina y esparteina - Google Patents
Procedimiento para la preparacion de una composicion de materia a base de un alcaloide de cornezuelo de centeno, papaverina y esparteinaInfo
- Publication number
- MX3493E MX3493E MX10022667U MX10022667U MX3493E MX 3493 E MX3493 E MX 3493E MX 10022667 U MX10022667 U MX 10022667U MX 10022667 U MX10022667 U MX 10022667U MX 3493 E MX3493 E MX 3493E
- Authority
- MX
- Mexico
- Prior art keywords
- sparteine
- papaverine
- vehicles
- water soluble
- physiologically tolerable
- Prior art date
Links
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 title abstract 7
- 239000000203 mixture Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- SLRCCWJSBJZJBV-ZQDZILKHSA-N sparteine Chemical compound C1N2CCCC[C@@H]2[C@@H]2CN3CCCC[C@H]3[C@H]1C2 SLRCCWJSBJZJBV-ZQDZILKHSA-N 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- 229930008281 A03AD01 - Papaverine Natural products 0.000 abstract 3
- 229930008564 C01BA04 - Sparteine Natural products 0.000 abstract 3
- SLRCCWJSBJZJBV-UHFFFAOYSA-N alpha-isosparteine Natural products C1N2CCCCC2C2CN3CCCCC3C1C2 SLRCCWJSBJZJBV-UHFFFAOYSA-N 0.000 abstract 3
- 229960001789 papaverine Drugs 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- SLRCCWJSBJZJBV-AJNGGQMLSA-N sparteine Chemical compound C1N2CCCC[C@H]2[C@@H]2CN3CCCC[C@H]3[C@H]1C2 SLRCCWJSBJZJBV-AJNGGQMLSA-N 0.000 abstract 3
- 229960001945 sparteine Drugs 0.000 abstract 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 abstract 2
- 235000021355 Stearic acid Nutrition 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 2
- 239000008187 granular material Substances 0.000 abstract 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 abstract 2
- 239000008108 microcrystalline cellulose Substances 0.000 abstract 2
- 229940016286 microcrystalline cellulose Drugs 0.000 abstract 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 abstract 2
- 239000008117 stearic acid Substances 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 150000003797 alkaloid derivatives Chemical class 0.000 abstract 1
- PBUNVLRHZGSROC-VTIMJTGVSA-N dihydro-alpha-ergocryptine Chemical compound C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)CC(C)C)C(C)C)=C3C2=CNC3=C1 PBUNVLRHZGSROC-VTIMJTGVSA-N 0.000 abstract 1
- 229960002032 dihydroergocryptine Drugs 0.000 abstract 1
- 229960003133 ergot alkaloid Drugs 0.000 abstract 1
- 235000013312 flour Nutrition 0.000 abstract 1
- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 238000004898 kneading Methods 0.000 abstract 1
- 235000021374 legumes Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
Landscapes
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a un procedimiento para la preparación de una composición de materia a base de un alcaloide de cornezuelo de centeno, papaverina y esparteína, que comprende los pasos de: formar a temperatura ambiente una combinación de 10 a 40 partes en peso de un constituyente molido de papaverina, seleccionado de papaverina y una sal soluble en agua fisiológicamente tolerable de la misma, y de 15 a 80 partes en peso de un constituyente molido de esparteína seleccionado de esparteína y de una sal soluble en agua fisiológicamente tolerable de la misma, con vehículos tales como celulosa microcristalina y harina de leguminosa; humedecer está combinación molida con una mezcla de disolventes tales como alcohol y agua, agregando si es necesario, vehículos adicionales tales como ácido esteárico; amazar la mezcla húmeda hasta que se encuentre lista para granulacion; secar el granulado durante varios minutos a una temperatura elevada preferiblemente de 30 a 50°C, quebrando el granulado si es necesario para secarlo posteriormente; y añadir cantidades adicionales de vehículos tales como celulosa microcristalina y ácido esteárico para formar postriormente la dosis unitaria de la composición de materia resultante, agregando durante el paso de amazado o de adición de vehículos, una parte en paso de un alcaliode hidrogenado de cornezuelo de centeno seleccionado de dihidroorgocristina, dihidro ergocriptina, dihidroergocornina y se sus sales solubles en agua fisiológicamente tolerables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR66851A FR5468M (es) | 1966-06-24 | 1966-06-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX3493E true MX3493E (es) | 1980-12-16 |
Family
ID=8611745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX10022667U MX3493E (es) | 1966-06-24 | 1967-06-22 | Procedimiento para la preparacion de una composicion de materia a base de un alcaloide de cornezuelo de centeno, papaverina y esparteina |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE700371A (es) |
| ES (1) | ES342172A1 (es) |
| FR (1) | FR5468M (es) |
| GB (1) | GB1180120A (es) |
| MX (1) | MX3493E (es) |
| NL (1) | NL6708490A (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4153700A (en) * | 1975-08-27 | 1979-05-08 | Lake Shore Roentgenology Ltd. | Treatment of the acute after-effects resulting from alcohol ingestion |
| IT1157365B (it) * | 1977-10-24 | 1987-02-11 | Sandoz Ag | Medicamenti per trattare l'obesita' o ridurre il peso del corpo |
| HU192050B (en) * | 1983-04-22 | 1987-05-28 | Sandoz Ag | Process for production of medical preparative containing co-dergocrin and one piridin-dicarbonic acid diesthertype calcium-antagonist |
| YU183988A (en) * | 1988-09-30 | 1990-08-31 | Lek Tovarna Farmacevtskih | Process for preparing dispersion pills of dihydroergotoxine |
-
1966
- 1966-06-24 FR FR66851A patent/FR5468M/fr not_active Expired
-
1967
- 1967-06-09 GB GB2675267A patent/GB1180120A/en not_active Expired
- 1967-06-19 NL NL6708490A patent/NL6708490A/xx unknown
- 1967-06-22 BE BE700371D patent/BE700371A/xx not_active IP Right Cessation
- 1967-06-22 MX MX10022667U patent/MX3493E/es unknown
- 1967-06-22 ES ES342172A patent/ES342172A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES342172A1 (es) | 1968-10-01 |
| GB1180120A (en) | 1970-02-04 |
| BE700371A (es) | 1967-12-22 |
| FR5468M (es) | 1967-10-16 |
| NL6708490A (es) | 1967-12-27 |
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