MX348665B - Process for extracting oleanolic acid from phoradendrom tomentosum. - Google Patents
Process for extracting oleanolic acid from phoradendrom tomentosum.Info
- Publication number
- MX348665B MX348665B MX2009009263A MX2009009263A MX348665B MX 348665 B MX348665 B MX 348665B MX 2009009263 A MX2009009263 A MX 2009009263A MX 2009009263 A MX2009009263 A MX 2009009263A MX 348665 B MX348665 B MX 348665B
- Authority
- MX
- Mexico
- Prior art keywords
- oleanolic acid
- tomentosum
- vegetal material
- phoradendrom
- extracting
- Prior art date
Links
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 title abstract 5
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 title abstract 5
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 title abstract 5
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 title abstract 5
- 229940100243 oleanolic acid Drugs 0.000 title abstract 5
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000000463 material Substances 0.000 abstract 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 2
- 241000196324 Embryophyta Species 0.000 abstract 1
- 241001342551 Macrophyllum Species 0.000 abstract 1
- 241000221046 Phoradendron leucarpum subsp. tomentosum Species 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 238000005238 degreasing Methods 0.000 abstract 1
- 235000015872 dietary supplement Nutrition 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Described is an extraction process for the isolation of oleanolic acid from Phoradendron tomentosum Macrophyllum. The process comprises the following steps: a) drying the vegetal material, b) degreasing the vegetal material with hexane, c) extracting the degreased vegetal material with medium-polarity solvents, d) concentrating the extract of the plant, e) purifying the concentrate using a step of column chromatography and a mixture of two solvents as mobile phase, and f) removing polar impurities by crystallising the oleanolic acid into methanol. The process results in an oleanolic acid of at least 95% purity, and a yield of 0.7% of the leaves and 0.25% of the stems. The oleanolic acid of high purity resulting from the present process may be added to food supplements, cosmetic or pharmaceutical formulations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2009009263A MX348665B (en) | 2009-08-28 | 2009-08-28 | Process for extracting oleanolic acid from phoradendrom tomentosum. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2009009263A MX348665B (en) | 2009-08-28 | 2009-08-28 | Process for extracting oleanolic acid from phoradendrom tomentosum. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2009009263A MX2009009263A (en) | 2011-02-28 |
| MX348665B true MX348665B (en) | 2017-05-26 |
Family
ID=44060816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009009263A MX348665B (en) | 2009-08-28 | 2009-08-28 | Process for extracting oleanolic acid from phoradendrom tomentosum. |
Country Status (1)
| Country | Link |
|---|---|
| MX (1) | MX348665B (en) |
-
2009
- 2009-08-28 MX MX2009009263A patent/MX348665B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009009263A (en) | 2011-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |