MX339866B - Metodo para analizar conjuntos de secuencias repetidas en tandem d4z4 de acido nucleico y paquete correspondiente. - Google Patents

Metodo para analizar conjuntos de secuencias repetidas en tandem d4z4 de acido nucleico y paquete correspondiente.

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Publication number
MX339866B
MX339866B MX2011003170A MX2011003170A MX339866B MX 339866 B MX339866 B MX 339866B MX 2011003170 A MX2011003170 A MX 2011003170A MX 2011003170 A MX2011003170 A MX 2011003170A MX 339866 B MX339866 B MX 339866B
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MX
Mexico
Prior art keywords
nucleic acid
kit
tandem repeat
repeat arrays
analyzing
Prior art date
Application number
MX2011003170A
Other languages
English (en)
Other versions
MX2011003170A (es
Inventor
Walrafen Pierre
Vannier Anne
Bensimon Aaron
Lévy Nicolas
Original Assignee
Genomic Vision
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genomic Vision filed Critical Genomic Vision
Publication of MX2011003170A publication Critical patent/MX2011003170A/es
Publication of MX339866B publication Critical patent/MX339866B/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un método para analizar in vitro arreglos de D4Z4 repetidos en tándem de ácido nucleico contenido en ácido nucleico representativo de cromosomas, en particular en ácido nucleico representativo de cromosomas 4 y 10 humanos, y a un paquete por lo tanto. Dicho método es adecuado en particular para determinar el número de unidades D4Z4 repetidas en dichos arreglos repetidos de D4Z4. Dicho método se basa en estiramiento de ácido nucleico y en particular en Combinación Molecular y depende del uso de sondas, especialmente sondas de ácido nucleico, con un diseño particular. La invención se refiere también a un método para proporcionar herramientas para la diagnosis de distrofia muscular facioscapulo-humeral (FSHD) y por lo tanto a un paquete de diagnosis. La invención se refiere además a un método para identificar eventos bioquímicos y/o genéticos en regiones que contienen tales arreglos repetidos en tándem.
MX2011003170A 2008-09-26 2009-09-25 Metodo para analizar conjuntos de secuencias repetidas en tandem d4z4 de acido nucleico y paquete correspondiente. MX339866B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08165310.7A EP2175037B1 (en) 2008-09-26 2008-09-26 Method for analyzing D4Z4 tandem repeat arrays of nucleic acid and kit therefore
PCT/IB2009/007197 WO2010035140A1 (en) 2008-09-26 2009-09-25 Method for analyzing d4z4 tandem repeat arrays of nucleic acid and kit therefore

Publications (2)

Publication Number Publication Date
MX2011003170A MX2011003170A (es) 2011-11-01
MX339866B true MX339866B (es) 2016-06-14

Family

ID=40279124

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011003170A MX339866B (es) 2008-09-26 2009-09-25 Metodo para analizar conjuntos de secuencias repetidas en tandem d4z4 de acido nucleico y paquete correspondiente.

Country Status (4)

Country Link
US (1) US9422607B2 (es)
EP (1) EP2175037B1 (es)
MX (1) MX339866B (es)
WO (1) WO2010035140A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2175037B1 (en) 2008-09-26 2017-10-11 Genomic Vision Method for analyzing D4Z4 tandem repeat arrays of nucleic acid and kit therefore
CN105734170A (zh) 2010-04-23 2016-07-06 基因组影像公司 通过由分子梳检测基因组和感染性病毒dna的病毒感染的诊断
EP4050109A1 (en) * 2010-08-18 2022-08-31 Fred Hutchinson Cancer Center Agents for use in treating facioscapulohumeral dystrophy (fshd)
WO2013120038A2 (en) * 2012-02-10 2013-08-15 Regents Of The University Of Minnesota Morpholino targeting dux4 for treating fshd
EP2861738A4 (en) * 2012-06-18 2015-12-23 Hutchinson Fred Cancer Res METHODS AND COMPOSITIONS ASSOCIATED WITH THE SMCHD1 GENE
WO2016057648A1 (en) * 2014-10-09 2016-04-14 University Of Massachusetts Medical Center Molecular diagnosis of fshd by epigenetic signature
EP3497239A4 (en) * 2016-08-10 2020-02-26 Ramot at Tel-Aviv University Ltd. METHYLATION STATUS ANALYSIS AND COPY NUMBER
EP3541955A1 (en) 2016-11-15 2019-09-25 Genomic Vision Method for the monitoring of modified nucleases induced-gene editing events by molecular combing
CN110199031A (zh) 2016-11-29 2019-09-03 基因组影像公司 设计用于分析感兴趣的遗传区域中的特定事件的一组多核苷酸序列的方法
DE202019005627U1 (de) * 2018-04-02 2021-05-31 Grail, Inc. Methylierungsmarker und gezielte Methylierungssondenpanels
CN113286881A (zh) 2018-09-27 2021-08-20 格里尔公司 甲基化标记和标靶甲基化探针板
EP4158050A4 (en) * 2020-05-29 2024-07-17 Childrens Nat Medical Ct GENETIC DIAGNOSIS TOOL FOR FACIOSCAPULO-HUMERAL MUSCULAR DYSTROPHY (FSHD)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2716263B1 (fr) 1994-02-11 1997-01-17 Pasteur Institut Procédé d'alignement de macromolécules par passage d'un ménisque et applications dans un procédé de mise en évidence, séparation et/ou dosage d'une macromolécule dans un échantillon.
FR2737574B1 (fr) 1995-08-03 1997-10-24 Pasteur Institut Appareillage d'alignement parallele de macromolecules et utilisation
FR2755149B1 (fr) 1996-10-30 1999-01-15 Pasteur Institut Procede de diagnostic de maladies genetiques par peignage moleculaire et coffret de diagnostic
US6248537B1 (en) 1999-05-28 2001-06-19 Institut Pasteur Use of the combing process for the identification of DNA origins of replication
US20050054012A1 (en) * 2002-10-11 2005-03-10 Tupler Rossella G. Methods of detecting and treating facioscapulohumeral muscular dystrophy
US7985542B2 (en) 2006-09-07 2011-07-26 Institut Pasteur Genomic morse code
EP2175037B1 (en) 2008-09-26 2017-10-11 Genomic Vision Method for analyzing D4Z4 tandem repeat arrays of nucleic acid and kit therefore

Also Published As

Publication number Publication date
WO2010035140A1 (en) 2010-04-01
WO2010035140A8 (en) 2010-08-05
EP2175037A1 (en) 2010-04-14
US9422607B2 (en) 2016-08-23
MX2011003170A (es) 2011-11-01
EP2175037B1 (en) 2017-10-11
US20130130924A1 (en) 2013-05-23

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