MX2023006545A - Formas solidas de (5s)-ciclopropil-5-[3-[(3s)-4-(3,5-difluorofenil )-3-metil-piperazin-1-il]-3-oxo-propil]imidazolidin-2,4-diona. - Google Patents

Formas solidas de (5s)-ciclopropil-5-[3-[(3s)-4-(3,5-difluorofenil )-3-metil-piperazin-1-il]-3-oxo-propil]imidazolidin-2,4-diona.

Info

Publication number
MX2023006545A
MX2023006545A MX2023006545A MX2023006545A MX2023006545A MX 2023006545 A MX2023006545 A MX 2023006545A MX 2023006545 A MX2023006545 A MX 2023006545A MX 2023006545 A MX2023006545 A MX 2023006545A MX 2023006545 A MX2023006545 A MX 2023006545A
Authority
MX
Mexico
Prior art keywords
solid forms
imidazolidine
difluorophenyl
dione
cyclopropyl
Prior art date
Application number
MX2023006545A
Other languages
English (en)
Inventor
Renaud Henri Marcel Lépine
Didier Philippe Robert Schils
Sam Bob Corveleyn
Michael Anthony Lynch
Nicolas Valentin Leblanc
Gradus Johannes Dulos
Original Assignee
Galapagos Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galapagos Nv filed Critical Galapagos Nv
Publication of MX2023006545A publication Critical patent/MX2023006545A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente invención se refiere a formas sólidas de (5S)-ciclopropil-5-[3-[(3S)-4-(3,5-difluorofenil)-3-metil-piperaz in-1-il]-3-oxo-propil]imidazolidin-2,4-diona y a preparaciones farmacéuticas que las comprenden y métodos para su manufactura, así como el uso de las formas sólidas o preparaciones para la profilaxis y/o tratamiento de afecciones inflamatorias, enfermedad muscular, enfermedades fibróticas, infección viral y/o enfermedades que involucran la degradación del cartílago y/o alteración de la homeostasis del cartílago, especialmente osteoartritis.
MX2023006545A 2020-12-15 2021-12-13 Formas solidas de (5s)-ciclopropil-5-[3-[(3s)-4-(3,5-difluorofenil )-3-metil-piperazin-1-il]-3-oxo-propil]imidazolidin-2,4-diona. MX2023006545A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20306578 2020-12-15
EP21170505 2021-04-26
PCT/EP2021/085376 WO2022128849A1 (en) 2020-12-15 2021-12-13 Solid forms of (5s)-cyclopropyl-5-[3-[(3s)-4-(3,5-difluorophenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione

Publications (1)

Publication Number Publication Date
MX2023006545A true MX2023006545A (es) 2023-06-16

Family

ID=78851033

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023006545A MX2023006545A (es) 2020-12-15 2021-12-13 Formas solidas de (5s)-ciclopropil-5-[3-[(3s)-4-(3,5-difluorofenil )-3-metil-piperazin-1-il]-3-oxo-propil]imidazolidin-2,4-diona.

Country Status (10)

Country Link
US (1) US20240124424A1 (es)
EP (1) EP4263530A1 (es)
JP (1) JP2023552908A (es)
KR (1) KR20230121762A (es)
AU (1) AU2021399788A1 (es)
CA (1) CA3205021A1 (es)
IL (1) IL303642A (es)
MX (1) MX2023006545A (es)
TW (1) TW202237590A (es)
WO (1) WO2022128849A1 (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE031089T2 (en) 2012-04-13 2017-06-28 Rottapharm Biotech Srl Anti-ADAMTS-5 antibody, derivatives and uses
JO3501B1 (ar) 2014-12-22 2020-07-05 Servier Lab مشتقات 5-{(بيبرازين - 1-يل)-3-أوكسو - بروبيل}- إيميدازوليدين-2، 4 - دايون كمثبطات ل adamts لمعالجة هشاشة العظام)

Also Published As

Publication number Publication date
KR20230121762A (ko) 2023-08-21
WO2022128849A1 (en) 2022-06-23
JP2023552908A (ja) 2023-12-19
AU2021399788A1 (en) 2023-08-03
EP4263530A1 (en) 2023-10-25
CA3205021A1 (en) 2022-06-23
TW202237590A (zh) 2022-10-01
IL303642A (en) 2023-08-01
US20240124424A1 (en) 2024-04-18

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