MX2023005855A - Inhibidores de calicreina plasmatica. - Google Patents

Inhibidores de calicreina plasmatica.

Info

Publication number
MX2023005855A
MX2023005855A MX2023005855A MX2023005855A MX2023005855A MX 2023005855 A MX2023005855 A MX 2023005855A MX 2023005855 A MX2023005855 A MX 2023005855A MX 2023005855 A MX2023005855 A MX 2023005855A MX 2023005855 A MX2023005855 A MX 2023005855A
Authority
MX
Mexico
Prior art keywords
plasma kallikrein
compounds
macular edema
kallikrein inhibitors
uveitis
Prior art date
Application number
MX2023005855A
Other languages
English (en)
Inventor
Song Yang
Dong Xiao
Salman Jabri
Christopher J Sinz
Alan C Cheng
Ying - Duo GAO
Jianming Bao
Maoqun Tian
Jovan Alexander Lopez
Rohan Merchant
Phillip Patrick Sharp
Natalija Cernaka
Anthony Ken Ogawa
Skylar K Osler
Haiqun Tang
Original Assignee
Merck Sharp & Dohme Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Llc filed Critical Merck Sharp & Dohme Llc
Publication of MX2023005855A publication Critical patent/MX2023005855A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

La presente invención proporciona un compuesto de Fórmula I (ver Fórmula) I y composiciones farmacéuticas que comprenden uno o más de dichos compuestos, y métodos para usar dichos compuestos para tratamiento o prevención de uno o más estados de enfermedad que podrían beneficiarse de la inhibición de calicreína plasmática, que incluyen angioedema hereditario, uveítis, uveítis posterior, edema macular húmedo relacionado con la edad, edema macular diabético, retinopatía diabética y oclusión de la vena retiniana. Los compuestos son inhibidores selectivos de calicreína plasmática.
MX2023005855A 2020-11-19 2021-11-18 Inhibidores de calicreina plasmatica. MX2023005855A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063115890P 2020-11-19 2020-11-19
PCT/US2021/059930 WO2022109161A1 (en) 2020-11-19 2021-11-18 Plasma kallikrein inhibitors

Publications (1)

Publication Number Publication Date
MX2023005855A true MX2023005855A (es) 2023-06-05

Family

ID=81709811

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023005855A MX2023005855A (es) 2020-11-19 2021-11-18 Inhibidores de calicreina plasmatica.

Country Status (9)

Country Link
US (1) US20240025917A1 (es)
EP (1) EP4247372A1 (es)
JP (1) JP2023551150A (es)
KR (1) KR20230110544A (es)
CN (1) CN116917293A (es)
AU (1) AU2021383762A1 (es)
CA (1) CA3198550A1 (es)
MX (1) MX2023005855A (es)
WO (1) WO2022109161A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4326274A1 (en) * 2021-04-22 2024-02-28 Merck Sharp & Dohme LLC Plasma kallikrein inhibitors
WO2023146809A1 (en) * 2022-01-25 2023-08-03 Merck Sharp & Dohme Llc Plasma kallikrein inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ568595A (en) * 2005-12-14 2010-04-30 Bristol Myers Squibb Co Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor Xla inhibitors
US10093683B2 (en) * 2014-04-22 2018-10-09 Merck Sharp & Dohme Corp. Factor XIa inhibitors
WO2017074833A1 (en) * 2015-10-29 2017-05-04 Merck Sharp & Dohme Corp. Macrocyclic spirocarbamate derivatives as factor xia inhibitors, pharmaceutically acceptable compositions and their use

Also Published As

Publication number Publication date
KR20230110544A (ko) 2023-07-24
US20240025917A1 (en) 2024-01-25
JP2023551150A (ja) 2023-12-07
EP4247372A1 (en) 2023-09-27
AU2021383762A1 (en) 2023-06-15
WO2022109161A1 (en) 2022-05-27
CN116917293A (zh) 2023-10-20
CA3198550A1 (en) 2022-05-27

Similar Documents

Publication Publication Date Title
MX2023005855A (es) Inhibidores de calicreina plasmatica.
MX2021008342A (es) Derivados de pirazol como inhibidores de calicreina plasmatica.
MX2020011495A (es) Inhibidores de bcl-2.
JOP20220142A1 (ar) مثبطات kras g12c
TN2019000136A1 (en) 2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of dhodh
PH12021550931A1 (en) New anthelmintic compounds
PH12020500257A1 (en) Quinoline derivatives for treating infections with helminths
EA201891703A1 (ru) Соединения бензопиразола и их аналоги
NO20070258L (no) Benzyltriazolonforbindelser som ikke-nukleoside revers transkriptase inhibitorer
MA53399B1 (fr) Pyrazoles substitués en tant qu`inhibiteurs de la kallicréine plasmatique humaine
PH12019502851A1 (en) New azaquinoline derivatives
WO2008016883A3 (en) Inhibitors of plasma kallikrein
MX2021014350A (es) Compuestos de 1-oxo-isoindolin-5-carboxamida sustituida, composiciones de los mismos y metodos de tratamiento con los mismos.
MX2022001784A (es) Piperidinil-metil-purinaminas como inhibidores de nsd2 y antineoplásicos.
MX2022009197A (es) Metodos de tratamiento para deficiencia de alfa-1 antitripsina.
EA202193019A1 (ru) Лечение наследственного ангионевротического отека
MX2021008400A (es) Inhibidores de dihidroorotato deshidrogenasa.
WO2008008701A3 (en) Substituted cyclopentane derivatives as therapeutic agents
MX2022012056A (es) Pirrolopirimidinaminas como inhibidores del sistema del complemento.
MX2022000545A (es) Inhibidores de enzimas.
MX2023001296A (es) Composiciones y metodos para tratar enfermedades y trastornos.
ZA202300912B (en) Tyk-2 inhibitor
TW200719903A (en) Compositions for the treatment of neoplasms
MX2021009971A (es) Compuesto heterociclico, composicion farmaceutica que lo comprende, metodo para su preparacion, y uso de estos.
MX2023000507A (es) Inhibidores de la calicreina plasmatica.