MX2023000577A - Compuesto de pirazolopirimidina usado como inhibidor de atr cinasa. - Google Patents
Compuesto de pirazolopirimidina usado como inhibidor de atr cinasa.Info
- Publication number
- MX2023000577A MX2023000577A MX2023000577A MX2023000577A MX2023000577A MX 2023000577 A MX2023000577 A MX 2023000577A MX 2023000577 A MX2023000577 A MX 2023000577A MX 2023000577 A MX2023000577 A MX 2023000577A MX 2023000577 A MX2023000577 A MX 2023000577A
- Authority
- MX
- Mexico
- Prior art keywords
- atr kinase
- compound used
- kinase inhibitor
- pyrazolopyrimidine compound
- compound
- Prior art date
Links
- 229940125775 ATR kinase inhibitor Drugs 0.000 title 1
- -1 Pyrazolopyrimidine compound Chemical class 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se divulga un compuesto de fórmula general (I), el cual puede usarse para el tratamiento de enfermedades mediadas por ATR cinasa, por ejemplo, enfermedades proliferativas, tal como cáncer. Se divulgan además un método de preparación para el compuesto de la fórmula general (I), una composición farmacéutica, y el uso de la composición farmacéutica para el tratamiento de enfermedades mediadas por ATR cinasa. (ver formula I).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010669088 | 2020-07-13 | ||
CN202011163505 | 2020-10-27 | ||
PCT/CN2021/105867 WO2022012484A1 (zh) | 2020-07-13 | 2021-07-13 | 作为atr激酶抑制剂的吡唑并嘧啶化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023000577A true MX2023000577A (es) | 2023-03-23 |
Family
ID=79274460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023000577A MX2023000577A (es) | 2020-07-13 | 2021-07-13 | Compuesto de pirazolopirimidina usado como inhibidor de atr cinasa. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20230271968A1 (es) |
EP (1) | EP4166556A4 (es) |
JP (1) | JP2023534676A (es) |
KR (1) | KR20230039675A (es) |
CN (2) | CN113929688B (es) |
AU (1) | AU2021310000A1 (es) |
BR (1) | BR112023000654A2 (es) |
CA (1) | CA3185963A1 (es) |
IL (1) | IL299804A (es) |
MX (1) | MX2023000577A (es) |
TW (1) | TW202202506A (es) |
WO (1) | WO2022012484A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117247386A (zh) * | 2022-01-18 | 2023-12-19 | 江苏亚尧生物科技有限公司 | 新型吡唑并嘧啶化合物及其组合物、制备方法和用途 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
SA111320519B1 (ar) * | 2010-06-11 | 2014-07-02 | Astrazeneca Ab | مركبات بيريميدينيل للاستخدام كمثبطات atr |
WO2012044641A1 (en) | 2010-09-29 | 2012-04-05 | Pathway Therapeutics Inc. | 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy |
EP2723745A1 (en) * | 2011-06-22 | 2014-04-30 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
JP6133291B2 (ja) * | 2011-08-12 | 2017-05-24 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ピラゾロ[3,4−c]ピリジン化合物と使用方法 |
TWI700283B (zh) * | 2014-08-04 | 2020-08-01 | 德商拜耳製藥公司 | 2-(嗎啉-4-基)-1,7-萘啶 |
ES2954572T3 (es) * | 2018-09-07 | 2023-11-23 | Merck Patent Gmbh | Derivados de 5-morfolin-4-il-pirazolo[4,3-b]piridina |
CN112142744A (zh) * | 2019-06-28 | 2020-12-29 | 上海瑛派药业有限公司 | 取代的稠合杂芳双环化合物作为激酶抑制剂及其应用 |
-
2021
- 2021-07-13 US US18/016,164 patent/US20230271968A1/en active Pending
- 2021-07-13 EP EP21843562.6A patent/EP4166556A4/en active Pending
- 2021-07-13 WO PCT/CN2021/105867 patent/WO2022012484A1/zh unknown
- 2021-07-13 AU AU2021310000A patent/AU2021310000A1/en active Pending
- 2021-07-13 TW TW110125595A patent/TW202202506A/zh unknown
- 2021-07-13 CN CN202110787074.4A patent/CN113929688B/zh active Active
- 2021-07-13 KR KR1020237004201A patent/KR20230039675A/ko active Search and Examination
- 2021-07-13 CA CA3185963A patent/CA3185963A1/en active Pending
- 2021-07-13 BR BR112023000654A patent/BR112023000654A2/pt unknown
- 2021-07-13 JP JP2023501863A patent/JP2023534676A/ja active Pending
- 2021-07-13 CN CN202180048970.7A patent/CN115943145A/zh active Pending
- 2021-07-13 IL IL299804A patent/IL299804A/en unknown
- 2021-07-13 MX MX2023000577A patent/MX2023000577A/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL299804A (en) | 2023-03-01 |
JP2023534676A (ja) | 2023-08-10 |
CN113929688A (zh) | 2022-01-14 |
KR20230039675A (ko) | 2023-03-21 |
BR112023000654A2 (pt) | 2023-04-25 |
CN113929688B (zh) | 2024-05-10 |
US20230271968A1 (en) | 2023-08-31 |
TW202202506A (zh) | 2022-01-16 |
EP4166556A4 (en) | 2024-06-26 |
AU2021310000A1 (en) | 2023-03-02 |
CA3185963A1 (en) | 2022-01-20 |
CN115943145A (zh) | 2023-04-07 |
WO2022012484A1 (zh) | 2022-01-20 |
EP4166556A1 (en) | 2023-04-19 |
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