MX2022004615A - Nuevas formulaciones. - Google Patents
Nuevas formulaciones.Info
- Publication number
- MX2022004615A MX2022004615A MX2022004615A MX2022004615A MX2022004615A MX 2022004615 A MX2022004615 A MX 2022004615A MX 2022004615 A MX2022004615 A MX 2022004615A MX 2022004615 A MX2022004615 A MX 2022004615A MX 2022004615 A MX2022004615 A MX 2022004615A
- Authority
- MX
- Mexico
- Prior art keywords
- new formulations
- formulations
- salt
- ampk
- thiadiazol
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- WEDWLYRQKUTOAX-UHFFFAOYSA-N 4-chloro-n-[2-[(4-chlorophenyl)methyl]-3-oxo-1,2,4-thiadiazol-5-yl]benzamide Chemical compound C1=CC(Cl)=CC=C1CN1C(=O)N=C(NC(=O)C=2C=CC(Cl)=CC=2)S1 WEDWLYRQKUTOAX-UHFFFAOYSA-N 0.000 abstract 1
- 102100036009 5'-AMP-activated protein kinase catalytic subunit alpha-2 Human genes 0.000 abstract 1
- 101000783681 Homo sapiens 5'-AMP-activated protein kinase catalytic subunit alpha-2 Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal salt Chemical class 0.000 abstract 1
- 230000001668 ameliorated effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201915094A GB201915094D0 (en) | 2019-10-18 | 2019-10-18 | New formulations |
| PCT/GB2020/052618 WO2021074646A1 (en) | 2019-10-18 | 2020-10-16 | New formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022004615A true MX2022004615A (es) | 2022-07-11 |
Family
ID=68728312
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022004615A MX2022004615A (es) | 2019-10-18 | 2020-10-16 | Nuevas formulaciones. |
| MX2025003950A MX2025003950A (es) | 2019-10-18 | 2022-04-18 | Composiciones de sales de metal alcalino de 4-cloro-n-[2-[(4-clorofenil)metil]-3-oxo-1,2,4-tiadiazol-5-il]benzamida |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2025003950A MX2025003950A (es) | 2019-10-18 | 2022-04-18 | Composiciones de sales de metal alcalino de 4-cloro-n-[2-[(4-clorofenil)metil]-3-oxo-1,2,4-tiadiazol-5-il]benzamida |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20230096218A1 (enExample) |
| EP (2) | EP4045038B1 (enExample) |
| JP (3) | JP7554263B2 (enExample) |
| KR (1) | KR20220084379A (enExample) |
| CN (2) | CN119112886A (enExample) |
| AU (1) | AU2020366142A1 (enExample) |
| CA (1) | CA3154915A1 (enExample) |
| DK (1) | DK4045038T3 (enExample) |
| ES (1) | ES2977279T3 (enExample) |
| FI (1) | FI4045038T3 (enExample) |
| GB (1) | GB201915094D0 (enExample) |
| HU (1) | HUE066075T2 (enExample) |
| MX (2) | MX2022004615A (enExample) |
| PL (1) | PL4045038T3 (enExample) |
| PT (1) | PT4045038T (enExample) |
| WO (1) | WO2021074646A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11691954B2 (en) | 2019-10-18 | 2023-07-04 | Betagenon Ab | Formulations |
| GB202100352D0 (en) * | 2021-01-12 | 2021-02-24 | Balticgruppen Bio Ab | New methods |
| WO2025017193A1 (en) * | 2023-07-20 | 2025-01-23 | Betagenon Ab | Methods of treating cardiomyopathy induced by metabolic inflexibility |
| WO2025017194A1 (en) * | 2023-07-20 | 2025-01-23 | Betagenon Ab | Methods for regulating blood glucose levels using a dual ampk activator and mitochondrial uncoupler |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2166328B1 (es) | 2000-05-11 | 2003-09-16 | Consejo Superior Investigacion | Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos |
| WO2006045581A1 (en) | 2004-10-21 | 2006-05-04 | Neuropharma, S.A. | The use of 1, 2, 4-thiadiazolidine-3, 5-diones as ppar activators |
| UA94724C2 (en) * | 2005-12-08 | 2011-06-10 | Новартис Аг | Thiadiazolidinone derivatives as antidiabetic agents |
| JP5982281B2 (ja) | 2009-07-08 | 2016-08-31 | バルティック バイオ アーベー | 医薬として有用な化合物 |
| WO2013108026A1 (en) * | 2012-01-17 | 2013-07-25 | Baltic Bio Ab | Thiadiazolone derivatives useful in the treatment of diabetes |
| AU2018448511B2 (en) * | 2018-11-05 | 2025-07-03 | Betagenon Ab | Methods of treating diabetes in severe insulin-resistant diabetic subjects |
-
2019
- 2019-10-18 GB GB201915094A patent/GB201915094D0/en not_active Ceased
-
2020
- 2020-10-16 US US17/769,666 patent/US20230096218A1/en not_active Abandoned
- 2020-10-16 DK DK20799795.8T patent/DK4045038T3/da active
- 2020-10-16 WO PCT/GB2020/052618 patent/WO2021074646A1/en not_active Ceased
- 2020-10-16 JP JP2022523275A patent/JP7554263B2/ja active Active
- 2020-10-16 CN CN202411247521.7A patent/CN119112886A/zh active Pending
- 2020-10-16 FI FIEP20799795.8T patent/FI4045038T3/fi active
- 2020-10-16 ES ES20799795T patent/ES2977279T3/es active Active
- 2020-10-16 PL PL20799795.8T patent/PL4045038T3/pl unknown
- 2020-10-16 CA CA3154915A patent/CA3154915A1/en active Pending
- 2020-10-16 CN CN202080072849.3A patent/CN114630824B/zh active Active
- 2020-10-16 AU AU2020366142A patent/AU2020366142A1/en active Pending
- 2020-10-16 EP EP20799795.8A patent/EP4045038B1/en active Active
- 2020-10-16 EP EP23200594.2A patent/EP4316470B1/en active Active
- 2020-10-16 KR KR1020227016816A patent/KR20220084379A/ko active Pending
- 2020-10-16 PT PT207997958T patent/PT4045038T/pt unknown
- 2020-10-16 MX MX2022004615A patent/MX2022004615A/es unknown
- 2020-10-16 HU HUE20799795A patent/HUE066075T2/hu unknown
-
2022
- 2022-04-18 MX MX2025003950A patent/MX2025003950A/es unknown
-
2024
- 2024-09-06 JP JP2024153951A patent/JP7771316B2/ja active Active
-
2025
- 2025-11-05 JP JP2025186783A patent/JP2026027357A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3154915A1 (en) | 2021-04-22 |
| US20230096218A1 (en) | 2023-03-30 |
| HUE066075T2 (hu) | 2024-07-28 |
| EP4316470B1 (en) | 2026-04-29 |
| EP4045038A1 (en) | 2022-08-24 |
| JP7554263B2 (ja) | 2024-09-19 |
| CN114630824B (zh) | 2024-09-24 |
| EP4045038B1 (en) | 2023-12-06 |
| CN119112886A (zh) | 2024-12-13 |
| MX2025003950A (es) | 2025-08-01 |
| FI4045038T3 (fi) | 2024-03-13 |
| AU2020366142A1 (en) | 2022-06-02 |
| JP2022553268A (ja) | 2022-12-22 |
| PL4045038T3 (pl) | 2024-06-24 |
| WO2021074646A1 (en) | 2021-04-22 |
| JP2024174965A (ja) | 2024-12-17 |
| JP7771316B2 (ja) | 2025-11-17 |
| PT4045038T (pt) | 2024-03-11 |
| ES2977279T3 (es) | 2024-08-21 |
| CN114630824A (zh) | 2022-06-14 |
| GB201915094D0 (en) | 2019-12-04 |
| JP2026027357A (ja) | 2026-02-18 |
| KR20220084379A (ko) | 2022-06-21 |
| DK4045038T3 (en) | 2024-03-18 |
| EP4316470A3 (en) | 2024-02-28 |
| EP4316470A2 (en) | 2024-02-07 |
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