MX2021014580A - Derivados heterociclos condensados como moduladores de ensamblaje de la capside. - Google Patents

Derivados heterociclos condensados como moduladores de ensamblaje de la capside.

Info

Publication number
MX2021014580A
MX2021014580A MX2021014580A MX2021014580A MX2021014580A MX 2021014580 A MX2021014580 A MX 2021014580A MX 2021014580 A MX2021014580 A MX 2021014580A MX 2021014580 A MX2021014580 A MX 2021014580A MX 2021014580 A MX2021014580 A MX 2021014580A
Authority
MX
Mexico
Prior art keywords
sup
capsid assembly
fused heterocycle
heterocycle derivatives
assembly modulators
Prior art date
Application number
MX2021014580A
Other languages
English (en)
Inventor
Scott D Kuduk
Original Assignee
Janssen Sciences Ireland Unlimited Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Unlimited Co filed Critical Janssen Sciences Ireland Unlimited Co
Publication of MX2021014580A publication Critical patent/MX2021014580A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se dan a conocer compuestos, composiciones y métodos para tratar enfermedades, síndromes, afecciones, y trastornos que se ven afectados por la modulación de CAM1; tales compuestos se representan mediante la Fórmula (I) tal como sigue: (ver Fórmula) donde, R1, R1A, R2, R3, R4, HET, n, X, Y, Z1 y Z2 se definen en el presente documento.
MX2021014580A 2019-05-28 2020-05-27 Derivados heterociclos condensados como moduladores de ensamblaje de la capside. MX2021014580A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962853528P 2019-05-28 2019-05-28
PCT/EP2020/064751 WO2020239864A1 (en) 2019-05-28 2020-05-27 Fused heterocycle derivatives as capsid assembly modulators

Publications (1)

Publication Number Publication Date
MX2021014580A true MX2021014580A (es) 2022-01-11

Family

ID=70968930

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021014580A MX2021014580A (es) 2019-05-28 2020-05-27 Derivados heterociclos condensados como moduladores de ensamblaje de la capside.

Country Status (10)

Country Link
US (1) US20220153754A1 (es)
EP (1) EP3976619A1 (es)
JP (1) JP2022535216A (es)
KR (1) KR20220015426A (es)
CN (1) CN113906031A (es)
AU (1) AU2020285314A1 (es)
BR (1) BR112021022960A2 (es)
CA (1) CA3136519A1 (es)
MX (1) MX2021014580A (es)
WO (1) WO2020239864A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024032409A1 (zh) * 2022-08-09 2024-02-15 成都百裕制药股份有限公司 哌嗪类化合物在联合放疗治疗肿瘤中的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107531691A (zh) * 2014-12-30 2018-01-02 诺维拉治疗公司 治疗乙型肝炎感染的衍生物和方法
WO2018005881A1 (en) 2016-06-29 2018-01-04 Novira Therapeutics, Inc. Oxadiazepinone derivatives and their use in the treatment of hepatitis b infections
CA3029566A1 (en) * 2016-06-29 2018-01-04 Novira Therapeutics, Inc. Diazepinone derivatives and their use in the treatment of hepatitis b infections

Also Published As

Publication number Publication date
BR112021022960A2 (pt) 2022-01-04
KR20220015426A (ko) 2022-02-08
AU2020285314A1 (en) 2021-11-25
WO2020239864A1 (en) 2020-12-03
JP2022535216A (ja) 2022-08-05
CN113906031A (zh) 2022-01-07
US20220153754A1 (en) 2022-05-19
CA3136519A1 (en) 2020-12-03
EP3976619A1 (en) 2022-04-06

Similar Documents

Publication Publication Date Title
MX2022005827A (es) Derivados de pirazol como inhibidores de malt1.
PH12021500014A1 (en) Fused ring compounds
WO2020097537A3 (en) Fused ring compounds
PH12020552207A1 (en) Pyrazole derivatives as malt1 inhibitors
MX2021013193A (es) Cicloalquilos sustituidos como moduladores de la vía integrada del estrés.
CR20210592A (es) Moduladores de la vía integrada del estrés
MX2021005714A (es) Nuevos compuestos heterociclicos.
MX2020013699A (es) Derivados de pirazol como inhibidores de malt1.
WO2019090085A8 (en) Modulators of the integrated stress pathway
MX2021014350A (es) Compuestos de 1-oxo-isoindolin-5-carboxamida sustituida, composiciones de los mismos y metodos de tratamiento con los mismos.
MX2021012706A (es) Inhibidores de dihidroorotato deshidrogenasa.
MX2021009521A (es) Inhibidores de dihidroorotato deshidrogenasa.
PH12017500653A1 (en) Substituted benzothiophenyl derivatives as gpr40 agonists for the treatment of type ii diabetes
CR20220004A (es) Nuevos compuestos heterocíclicos
EA202190272A1 (ru) Дополнительно замещенные производные триазолохиноксалина
EA202190271A1 (ru) Замещенные триазолохиноксалиновые производные
MX2023011065A (es) Derivados de heteroarilos biciclicos como inhibidores de ectonucleotido pirofosfatasa fosfodiesterasa 1.
MX2021000625A (es) Dinucleotidos ciclicos como agonistas de sting.
MX2021014580A (es) Derivados heterociclos condensados como moduladores de ensamblaje de la capside.
PH12020500600A1 (en) Triazole, imidazole and pyrrole condensed piperazine derivatives and their use as modulators of mglu5 receptors
MX2021012417A (es) Anillos de piridina que contienen derivados como inhibidores de malt1.
MX2023005928A (es) Moduladores de malt-1.
MX2021014582A (es) Derivados de diazepinona como moduladores del ensamblaje de la capside.
MX2021014578A (es) Azepinas como moduladores del ensamblaje de la cápside del vhb.
MX2021014577A (es) Difluoroazepanos como moduladores del ensamblaje de la cápside del vhb.