MX2021014577A - Difluoroazepanos como moduladores del ensamblaje de la cápside del vhb. - Google Patents

Difluoroazepanos como moduladores del ensamblaje de la cápside del vhb.

Info

Publication number
MX2021014577A
MX2021014577A MX2021014577A MX2021014577A MX2021014577A MX 2021014577 A MX2021014577 A MX 2021014577A MX 2021014577 A MX2021014577 A MX 2021014577A MX 2021014577 A MX2021014577 A MX 2021014577A MX 2021014577 A MX2021014577 A MX 2021014577A
Authority
MX
Mexico
Prior art keywords
azepanes
fluoro
capsid assembly
hbv capsid
assembly modulators
Prior art date
Application number
MX2021014577A
Other languages
English (en)
Inventor
Scott D Kuduk
Lindsey Graham Deratt
Original Assignee
Janssen Sciences Ireland Unlimited Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Unlimited Co filed Critical Janssen Sciences Ireland Unlimited Co
Publication of MX2021014577A publication Critical patent/MX2021014577A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se divulgan compuestos, composiciones y métodos para tratar enfermedades, síndromes, afecciones y trastornos que se ven afectados por la modulación de CAM1; tales compuestos se representan mediante la Fórmula (I) tal como sigue: (ver fórmula) en donde R1a, R1b, R2 , R3 , R4 y X se definen en la presente.
MX2021014577A 2019-05-28 2020-05-27 Difluoroazepanos como moduladores del ensamblaje de la cápside del vhb. MX2021014577A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962853554P 2019-05-28 2019-05-28
PCT/EP2020/064747 WO2020239862A1 (en) 2019-05-28 2020-05-27 Di-fluoro azepanes as hbv capsid assembly modulators

Publications (1)

Publication Number Publication Date
MX2021014577A true MX2021014577A (es) 2022-03-17

Family

ID=70968928

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021014577A MX2021014577A (es) 2019-05-28 2020-05-27 Difluoroazepanos como moduladores del ensamblaje de la cápside del vhb.

Country Status (10)

Country Link
US (1) US20220235051A1 (es)
EP (1) EP3976614A1 (es)
JP (1) JP2022534247A (es)
KR (1) KR20220012320A (es)
CN (1) CN113939511A (es)
AU (1) AU2020281803A1 (es)
BR (1) BR112021023456A2 (es)
CA (1) CA3138159A1 (es)
MX (1) MX2021014577A (es)
WO (1) WO2020239862A1 (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016109684A2 (en) * 2014-12-30 2016-07-07 Novira Therapeutics, Inc. Derivatives and methods of treating hepatitis b infections
CN109641896B (zh) * 2016-06-29 2021-09-21 诺维拉治疗公司 二氮杂酮衍生物及其在治疗乙型肝炎感染中的用途

Also Published As

Publication number Publication date
EP3976614A1 (en) 2022-04-06
KR20220012320A (ko) 2022-02-03
US20220235051A1 (en) 2022-07-28
CN113939511A (zh) 2022-01-14
JP2022534247A (ja) 2022-07-28
BR112021023456A2 (pt) 2022-01-18
CA3138159A1 (en) 2020-12-03
WO2020239862A1 (en) 2020-12-03
AU2020281803A1 (en) 2021-11-25

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MX2021014577A (es) Difluoroazepanos como moduladores del ensamblaje de la cápside del vhb.