MX2021013597A - El polipeptido ix adenoviral aumenta la productividad y la infectividad del vector adenoviral de terapia genica. - Google Patents

El polipeptido ix adenoviral aumenta la productividad y la infectividad del vector adenoviral de terapia genica.

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Publication number
MX2021013597A
MX2021013597A MX2021013597A MX2021013597A MX2021013597A MX 2021013597 A MX2021013597 A MX 2021013597A MX 2021013597 A MX2021013597 A MX 2021013597A MX 2021013597 A MX2021013597 A MX 2021013597A MX 2021013597 A MX2021013597 A MX 2021013597A
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Mexico
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express
adenoviral
adenovirus
polypeptide
gene therapy
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MX2021013597A
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English (en)
Inventor
Vesa Turkki
Saana Lepola
Hanna Lesch
Seppo Yla-Herttuala
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Kuopio Center for Gene and Cell Therapy Oy
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Application filed by Kuopio Center for Gene and Cell Therapy Oy filed Critical Kuopio Center for Gene and Cell Therapy Oy
Publication of MX2021013597A publication Critical patent/MX2021013597A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86—Viral vectors
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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Abstract

La producción de un vector de terapia génica de adenovirus en células productoras que expresan o sobreexpresan el polipéptido IX adenoviral o sus formas truncadas permite producir adenovirus con eliminación de pIX en cultivos de células en suspensión. El uso de células productoras que expresan o sobreexpresan el polipéptido IX adenoviral o sus formas truncadas también aumenta el rendimiento del vector adenoviral, independientemente de que el adenovirus tenga eliminación de pIX. El uso de células productoras que expresan o sobreexpresan el polipéptido IX adenoviral o formas truncadas del mismo también mejora la cinética de transducción del vector resultante, reduciendo el número de ufp/célula diana requeridas para alcanzar un nivel determinado de transducción/infección, acortando el tiempo que el vector necesita para transducir o infectar una célula diana, y acortando el tiempo en que una célula diana infectada produce progenie de virus.
MX2021013597A 2019-05-07 2020-05-01 El polipeptido ix adenoviral aumenta la productividad y la infectividad del vector adenoviral de terapia genica. MX2021013597A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962844175P 2019-05-07 2019-05-07
US16/423,215 US20190315808A1 (en) 2019-05-07 2019-05-28 Adenoviral Polypeptide IX Increases Adenoviral Gene Therapy Vector Productivity and Infectivity
US16/569,742 US20200354409A1 (en) 2019-05-07 2019-09-13 Adenoviral Polypeptide IX Increases Adenoviral Gene Therapy Vector Productivity and Infectivity
PCT/US2020/030924 WO2020227049A1 (en) 2019-05-07 2020-05-01 Adenoviral polypeptide ix increases adenoviral gene therapy vector productivity and infectivity

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MX2021013597A true MX2021013597A (es) 2022-02-11

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US (2) US20190315808A1 (es)
EP (1) EP3965787A4 (es)
JP (1) JP2022532138A (es)
KR (1) KR20220012863A (es)
CN (1) CN114450017A (es)
AU (1) AU2020267343A1 (es)
BR (1) BR112021022311A2 (es)
CA (1) CA3136313A1 (es)
IL (1) IL287846A (es)
MX (1) MX2021013597A (es)
WO (1) WO2020227049A1 (es)

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US20190315808A1 (en) * 2019-05-07 2019-10-17 Kuopio Center for Gene and Cell Therapy Oy Adenoviral Polypeptide IX Increases Adenoviral Gene Therapy Vector Productivity and Infectivity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5880102A (en) * 1995-01-17 1999-03-09 Duke University Adenoviral vector system
WO1999057296A1 (en) * 1998-05-01 1999-11-11 Genzyme Corporation Partially deleted adenoviral vectors
AU2001291162A1 (en) * 2000-09-25 2002-04-08 Regents Of The University Of Michigan Production of viral vectors
JP2005536231A (ja) * 2002-05-08 2005-12-02 イントロン，インコーポレーテッド アデノウイルスに細胞選択的複製をもたらすための、スプライセオソーム媒介型ｒｎａトランススプライシングの使用
US20090253184A1 (en) * 2008-01-23 2009-10-08 Introgen Therapeutics, Inc. Compositions and methods related to an adenoviral trans-complementing cell line
CA2792537A1 (en) * 2010-03-30 2011-10-06 Mount Sinai School Of Medicine Influenza virus vaccines and uses thereof
US20190315808A1 (en) * 2019-05-07 2019-10-17 Kuopio Center for Gene and Cell Therapy Oy Adenoviral Polypeptide IX Increases Adenoviral Gene Therapy Vector Productivity and Infectivity

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CA3136313A1 (en) 2020-11-12
CN114450017A (zh) 2022-05-06
US20190315808A1 (en) 2019-10-17
US20200354409A1 (en) 2020-11-12
KR20220012863A (ko) 2022-02-04
BR112021022311A2 (pt) 2021-12-28
EP3965787A4 (en) 2023-09-13
JP2022532138A (ja) 2022-07-13
EP3965787A1 (en) 2022-03-16
AU2020267343A1 (en) 2021-12-16
IL287846A (en) 2022-01-01
WO2020227049A1 (en) 2020-11-12

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