MX2021012740A - Péptidos y nanopartículas para entrega intracelular de moléculas. - Google Patents

Péptidos y nanopartículas para entrega intracelular de moléculas.

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Publication number
MX2021012740A
MX2021012740A MX2021012740A MX2021012740A MX2021012740A MX 2021012740 A MX2021012740 A MX 2021012740A MX 2021012740 A MX2021012740 A MX 2021012740A MX 2021012740 A MX2021012740 A MX 2021012740A MX 2021012740 A MX2021012740 A MX 2021012740A
Authority
MX
Mexico
Prior art keywords
peptide
cpp
cargo
directed
present application
Prior art date
Application number
MX2021012740A
Other languages
English (en)
Inventor
Gilles Divita
Neil P Desai
Original Assignee
Aadigen Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aadigen Llc filed Critical Aadigen Llc
Publication of MX2021012740A publication Critical patent/MX2021012740A/es

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente solicitud está dirigida a complejos de entrega de carga para la entrega intracelular de una molécula de carga que comprende: un primer péptido que comprende un péptido que penetra en las células (CPP), un segundo péptido que comprende un péptido que penetra en las células y una molécula de carga. El segundo péptido comprende un resto de polietilenglicol (PEG) unido al segundo CPP, y el primer péptido no tiene un resto de PEG. La presente solicitud también está dirigida a un complejo de entrega de carga que comprende un CPP y una molécula de carga en donde el CPP es un péptido retro-inverso. La presente solicitud también está dirigida a un complejo de entrega de carga que comprende un CPP y una molécula de carga en donde el péptido comprende además una 15 secuencia de direccionamiento seleccionada del grupo que consiste en GYVSK, GYVS, YIGS y YIGSR. También se describen métodos para fabricar y usar los complejos de entrega de carga.
MX2021012740A 2019-04-17 2020-04-16 Péptidos y nanopartículas para entrega intracelular de moléculas. MX2021012740A (es)

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CA3137137A1 (en) 2020-10-22
IL287321A (en) 2021-12-01
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