MX2021011374A - Compuestos de heteroaril(heterocyclil)metanol útiles en el tratamiento de la hiperglucemia. - Google Patents

Compuestos de heteroaril(heterocyclil)metanol útiles en el tratamiento de la hiperglucemia.

Info

Publication number
MX2021011374A
MX2021011374A MX2021011374A MX2021011374A MX2021011374A MX 2021011374 A MX2021011374 A MX 2021011374A MX 2021011374 A MX2021011374 A MX 2021011374A MX 2021011374 A MX2021011374 A MX 2021011374A MX 2021011374 A MX2021011374 A MX 2021011374A
Authority
MX
Mexico
Prior art keywords
hyperglycaemia
heterocyclyl
heteroaryl
treatment
sup
Prior art date
Application number
MX2021011374A
Other languages
English (en)
Inventor
Benjamin Pelcman
Tore Bengtsson
Original Assignee
Atrogi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atrogi Ab filed Critical Atrogi Ab
Publication of MX2021011374A publication Critical patent/MX2021011374A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En la presente se proporciona un compuesto de fórmula I (VER FORMULA) o una sal farmacéuticamente aceptable de este, en donde el anillo que contiene Q1 a Q5 , R1 , m, X1 y el anillo A tienen los significados que se proporcionan en la descripción.
MX2021011374A 2019-03-20 2020-03-20 Compuestos de heteroaril(heterocyclil)metanol útiles en el tratamiento de la hiperglucemia. MX2021011374A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1903832.2A GB201903832D0 (en) 2019-03-20 2019-03-20 New compounds and methods
PCT/GB2020/050760 WO2020188299A1 (en) 2019-03-20 2020-03-20 Heteroaryl(heterocyclyl)methanol compounds useful in the treatment of hyperglycaemia

Publications (1)

Publication Number Publication Date
MX2021011374A true MX2021011374A (es) 2022-01-06

Family

ID=66381120

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021011374A MX2021011374A (es) 2019-03-20 2020-03-20 Compuestos de heteroaril(heterocyclil)metanol útiles en el tratamiento de la hiperglucemia.

Country Status (13)

Country Link
US (1) US20220194920A1 (es)
EP (1) EP3941913A1 (es)
JP (1) JP2022525948A (es)
KR (1) KR20220002903A (es)
CN (1) CN113784961A (es)
AU (1) AU2020243454A1 (es)
BR (1) BR112021018587A2 (es)
CA (1) CA3133890A1 (es)
GB (1) GB201903832D0 (es)
IL (1) IL286447A (es)
MX (1) MX2021011374A (es)
TW (1) TW202102486A (es)
WO (1) WO2020188299A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB202204085D0 (en) * 2022-03-23 2022-05-04 Atrogi Ab New compounds and methods

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1156216C (zh) 1998-06-18 2004-07-07 诺瓦提斯公司 驱避与防止害虫的组合物
MXPA04011958A (es) * 2002-06-04 2005-03-31 Pfizer Prod Inc Amidas ciclicas fluoradas como inhibidores de la dipeptidil peptidasa iv.
FR2861073B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
HUP0400405A3 (en) * 2004-02-10 2009-03-30 Sanofi Synthelabo Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
US8735604B2 (en) * 2009-09-22 2014-05-27 Merck Sharp & Dohme Corp. Pyrrolidines as glucagon receptor antagonists, compositions, and methods for their use

Also Published As

Publication number Publication date
JP2022525948A (ja) 2022-05-20
CN113784961A (zh) 2021-12-10
US20220194920A1 (en) 2022-06-23
CA3133890A1 (en) 2020-09-24
EP3941913A1 (en) 2022-01-26
KR20220002903A (ko) 2022-01-07
WO2020188299A1 (en) 2020-09-24
GB201903832D0 (en) 2019-05-01
AU2020243454A1 (en) 2021-11-04
BR112021018587A2 (pt) 2021-11-23
IL286447A (en) 2021-10-31
TW202102486A (zh) 2021-01-16

Similar Documents

Publication Publication Date Title
MX2020002825A (es) Beta-hidroxietilaminas heteroaril sustituidas para su uso en el tratamiento de hiperglucemia.
MX2021011374A (es) Compuestos de heteroaril(heterocyclil)metanol útiles en el tratamiento de la hiperglucemia.
MX2021000795A (es) Compuestos heterociclicos para inhibir la actividad de shp2.
MX2021011286A (es) Compuestos de heterociclil(fenil)metanol útiles en el tratamiento de la hiperglucemia.
PH12021550045A1 (en) 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
MX2021013472A (es) Moduladores de thr-? y metodos de uso de estos.
WO2019173082A8 (en) Substituted 1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones
MX2020013817A (es) Compuestos de naftiridinona sustituidos utiles como activadores de celulas t.
MX2022007372A (es) Compuestos de heteroarilo sustituidos utiles como activadores de celulas t.
EP4249054A3 (en) Fluorophenyl beta-hydroxyethylamines and their use in the treatment of hyperglycaemia
MX2020009530A (es) Inhibidores de la o-glicoproteína-2-acetamido-2-desoxi-3-dglicopir anosidasa.
EA201001669A1 (ru) Замещенные пиримидин-5-карбоксамиды 281
AU2018253590A1 (en) Imidazopyridazine compounds
GEP20156368B (en) Non-nucleoside reverse transcriptase inhibitors
EA017861B9 (ru) Способ получения 4-оксохинолинового соединения
MX2022016515A (es) Nuevo inhibidor de la secrecion de acido y uso del mismo.
MX2020000576A (es) Compuestos quimicos.
CA3156303A1 (en) 5-FLUORONICOTINAMIDE DERIVATIVES AND THEIR USES
MX2023009037A (es) Compuesto de pirimidopirano.
WO2021079196A3 (en) Mettl3 modulators
MX2021012105A (es) Compuestos de pirrol.
MX2013002620A (es) Novedosas n-hidroxi-benzamidas para el tratamiento del cancer.
TN2017000342A1 (en) Novel cyclopropabenzofuranyl pyridopyrazinediones
MY152557A (en) 3-aminocyclopentanecarboxamides as chemokine receptor modulators
CR20210014A (es) Derivados de pirrolo [1,2-b] piridazina