MX2021010896A - Methods, devices, and systems for analyte detection and analysis. - Google Patents

Methods, devices, and systems for analyte detection and analysis.

Info

Publication number
MX2021010896A
MX2021010896A MX2021010896A MX2021010896A MX2021010896A MX 2021010896 A MX2021010896 A MX 2021010896A MX 2021010896 A MX2021010896 A MX 2021010896A MX 2021010896 A MX2021010896 A MX 2021010896A MX 2021010896 A MX2021010896 A MX 2021010896A
Authority
MX
Mexico
Prior art keywords
substrate
analysis
systems
methods
analyte detection
Prior art date
Application number
MX2021010896A
Other languages
Spanish (es)
Inventor
Phillip You Fai Lee
Gilad Almogy
Nathan Beckett
Nathan Caswell
Jacob A Wolf
Kristopher Barbee
Denis Pristinski
Mark Pratt
Gene Polovy
Osip Schwartz
Stephanie Kubecka
Steven Menchen
Joseph Anthony
Jose Martin Sosa
Original Assignee
Ultima Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/445,798 external-priority patent/US10900078B2/en
Priority claimed from US16/677,067 external-priority patent/US10830703B1/en
Priority claimed from US16/677,115 external-priority patent/US10852518B1/en
Application filed by Ultima Genomics Inc filed Critical Ultima Genomics Inc
Publication of MX2021010896A publication Critical patent/MX2021010896A/en

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
    • B01J4/007—Feed or outlet devices as such, e.g. feeding tubes provided with moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/26—Stages; Adjusting means therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/10—Scanning
    • G01N2201/104—Mechano-optical scan, i.e. object and beam moving

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Microscoopes, Condenser (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Spectroscopy & Molecular Physics (AREA)

Abstract

Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.
MX2021010896A 2019-03-14 2020-03-13 Methods, devices, and systems for analyte detection and analysis. MX2021010896A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962818549P 2019-03-14 2019-03-14
US201962837684P 2019-04-23 2019-04-23
US16/445,798 US10900078B2 (en) 2019-03-14 2019-06-19 Methods, devices, and systems for analyte detection and analysis
US201962914293P 2019-10-11 2019-10-11
US16/677,067 US10830703B1 (en) 2019-03-14 2019-11-07 Methods, devices, and systems for analyte detection and analysis
US16/677,115 US10852518B1 (en) 2019-03-14 2019-11-07 Methods, devices, and systems for analyte detection and analysis
PCT/US2020/022816 WO2020186243A1 (en) 2019-03-14 2020-03-13 Methods, devices, and systems for analyte detection and analysis

Publications (1)

Publication Number Publication Date
MX2021010896A true MX2021010896A (en) 2023-03-16

Family

ID=72426853

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021010896A MX2021010896A (en) 2019-03-14 2020-03-13 Methods, devices, and systems for analyte detection and analysis.

Country Status (9)

Country Link
EP (1) EP3938832A4 (en)
JP (1) JP7530909B2 (en)
KR (1) KR20210150402A (en)
CN (1) CN113841078B (en)
AU (2) AU2020239263B2 (en)
CA (2) CA3238741A1 (en)
MX (1) MX2021010896A (en)
SG (1) SG11202109764VA (en)
WO (1) WO2020186243A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10267790B1 (en) 2017-11-17 2019-04-23 Ultima Genomics, Inc. Systems for biological sample processing and analysis
US11499962B2 (en) 2017-11-17 2022-11-15 Ultima Genomics, Inc. Methods and systems for analyte detection and analysis
US10512911B1 (en) 2018-12-07 2019-12-24 Ultima Genomics, Inc. Implementing barriers for controlled environments during sample processing and detection
US10900078B2 (en) 2019-03-14 2021-01-26 Ultima Genomics, Inc. Methods, devices, and systems for analyte detection and analysis
US11118223B2 (en) 2019-03-14 2021-09-14 Ultima Genomics, Inc. Methods, devices, and systems for analyte detection and analysis
US20220403466A1 (en) * 2021-06-17 2022-12-22 Mgi Tech Co., Ltd. Sequencing systems and methods utilizing curved imaging paths on rotating substrates
KR20230091463A (en) * 2021-12-16 2023-06-23 (주)레보스케치 Rotational-type multi-channel fluorescence scanner
CN115041157B (en) * 2022-06-10 2023-08-08 佛山科学技术学院 Hydrogen production catalyst carrier and preparation method thereof
KR102704324B1 (en) * 2022-11-16 2024-09-09 한국수자원공사 Monitoring Apparatus For Small Creatures and Monitoring Method Using the Same
WO2024130655A1 (en) * 2022-12-22 2024-06-27 深圳华大生命科学研究院 Reagent delivery method and surface liquid path system used for gene sequencing
CN116930481A (en) * 2023-09-12 2023-10-24 重庆医科大学绍兴柯桥医学检验技术研究中心 Cross-molecule detection method for magnetic field driven micro-nano motor

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962020A (en) 1988-07-12 1990-10-09 President And Fellows Of Harvard College DNA sequencing
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US5800997A (en) * 1996-11-01 1998-09-01 Novartis Finance Corporation Detection of maize fungal pathogens using the polymerase chain reaction
US6320609B1 (en) * 1998-07-10 2001-11-20 Nanometrics Incorporated System using a polar coordinate stage and continuous image rotation to compensate for stage rotation
US20020055112A1 (en) * 2000-08-26 2002-05-09 Nila Patil Methods for reducing complexity of nucleic acid samples
US7689022B2 (en) * 2002-03-15 2010-03-30 Affymetrix, Inc. System, method, and product for scanning of biological materials
US20030224506A1 (en) 2002-05-30 2003-12-04 Biomicroarrays Inc Tiled biochips and the methods of making the same
US9976192B2 (en) * 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
JP4866462B2 (en) 2006-08-03 2012-02-01 ナショナル ユニバーシティ オブ シンガポール Microarray system and method for manufacturing microarray
CN101893523A (en) * 2009-05-20 2010-11-24 纳米基因有限公司 Analyte detecting method and composite
KR101567195B1 (en) * 2013-03-14 2015-11-06 가부시키가이샤 스크린 홀딩스 Ejection inspection apparatus and substrate processing apparatus
WO2014143981A1 (en) 2013-03-15 2014-09-18 Massachusetts Institute Of Technology Deposition and imaging of particles on planar substrates
US10512911B1 (en) 2018-12-07 2019-12-24 Ultima Genomics, Inc. Implementing barriers for controlled environments during sample processing and detection

Also Published As

Publication number Publication date
CA3238741A1 (en) 2020-09-17
EP3938832A1 (en) 2022-01-19
EP3938832A4 (en) 2023-03-22
CA3129726A1 (en) 2020-09-17
AU2024205158A1 (en) 2024-08-15
WO2020186243A1 (en) 2020-09-17
CN113841078A (en) 2021-12-24
SG11202109764VA (en) 2021-10-28
CN113841078B (en) 2024-10-01
JP2022526715A (en) 2022-05-26
JP7530909B2 (en) 2024-08-08
KR20210150402A (en) 2021-12-10
AU2020239263B2 (en) 2024-05-02
AU2024205158B2 (en) 2024-08-22
AU2020239263A1 (en) 2021-10-07

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