MX2021009959A - Boron schiff bases (boschibas) derived from a-amino acids, their ligands, and their use as fluorescent agents for cell staining. - Google Patents
Boron schiff bases (boschibas) derived from a-amino acids, their ligands, and their use as fluorescent agents for cell staining.Info
- Publication number
- MX2021009959A MX2021009959A MX2021009959A MX2021009959A MX2021009959A MX 2021009959 A MX2021009959 A MX 2021009959A MX 2021009959 A MX2021009959 A MX 2021009959A MX 2021009959 A MX2021009959 A MX 2021009959A MX 2021009959 A MX2021009959 A MX 2021009959A
- Authority
- MX
- Mexico
- Prior art keywords
- boschibas
- boron
- derived
- amino acids
- ligands
- Prior art date
Links
- -1 Boron schiff bases Chemical class 0.000 title abstract 2
- 239000002262 Schiff base Substances 0.000 title abstract 2
- 229910052796 boron Inorganic materials 0.000 title abstract 2
- 239000007850 fluorescent dye Substances 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 238000010186 staining Methods 0.000 title abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- QJYKUYUDWYBTAI-UHFFFAOYSA-N C=1C=CC=CC=1OBOC1=CC=CC=C1 Chemical compound C=1C=CC=CC=1OBOC1=CC=CC=C1 QJYKUYUDWYBTAI-UHFFFAOYSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 239000000090 biomarker Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 238000004624 confocal microscopy Methods 0.000 abstract 1
- 210000000805 cytoplasm Anatomy 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention aims to provide a group of Boron Schiff Bases (BOSCHIBAS) derived from a-amino acids (Glycine, Tryptophan, Phenylalanine) synthesized by condensation of di-phenylboronic acid (generated in situ) with their corresponding ligands, and their use as dual cellular staining fluorescent agents for nucleoli and cytoplasm. Said bases present adequate photophysical properties and low toxicity, using them as fluorescent biomarkers in cells for confocal microscopy and making them good candidates for medical diagnosis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2021009959A MX2021009959A (en) | 2021-08-18 | 2021-08-18 | Boron schiff bases (boschibas) derived from a-amino acids, their ligands, and their use as fluorescent agents for cell staining. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2021009959A MX2021009959A (en) | 2021-08-18 | 2021-08-18 | Boron schiff bases (boschibas) derived from a-amino acids, their ligands, and their use as fluorescent agents for cell staining. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021009959A true MX2021009959A (en) | 2023-02-20 |
Family
ID=89574941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021009959A MX2021009959A (en) | 2021-08-18 | 2021-08-18 | Boron schiff bases (boschibas) derived from a-amino acids, their ligands, and their use as fluorescent agents for cell staining. |
Country Status (1)
| Country | Link |
|---|---|
| MX (1) | MX2021009959A (en) |
-
2021
- 2021-08-18 MX MX2021009959A patent/MX2021009959A/en unknown
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