MX2021006447A - Process for preparing polymeric particles. - Google Patents
Process for preparing polymeric particles.Info
- Publication number
- MX2021006447A MX2021006447A MX2021006447A MX2021006447A MX2021006447A MX 2021006447 A MX2021006447 A MX 2021006447A MX 2021006447 A MX2021006447 A MX 2021006447A MX 2021006447 A MX2021006447 A MX 2021006447A MX 2021006447 A MX2021006447 A MX 2021006447A
- Authority
- MX
- Mexico
- Prior art keywords
- weight
- polymeric particles
- methacrylic acid
- further monomers
- polymerized units
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/12—Polymerisation in non-solvents
- C08F2/16—Aqueous medium
- C08F2/22—Emulsion polymerisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/001—Multistage polymerisation processes characterised by a change in reactor conditions without deactivating the intermediate polymer
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/04—Acids; Metal salts or ammonium salts thereof
- C08F220/06—Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/14—Methyl esters, e.g. methyl (meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
- C08J3/126—Polymer particles coated by polymer, e.g. core shell structures
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2800/00—Copolymer characterised by the proportions of the comonomers expressed
- C08F2800/20—Copolymer characterised by the proportions of the comonomers expressed as weight or mass percentages
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
- C08J2333/04—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers esters
- C08J2333/06—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers esters of esters containing only carbon, hydrogen, and oxygen, the oxygen atom being present only as part of the carboxyl radical
- C08J2333/10—Homopolymers or copolymers of methacrylic acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Polymerisation Methods In General (AREA)
- General Preparation And Processing Of Foods (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
The invention relates to a process for preparing polymeric particles, comprising polymerized units of methacrylic acid and further monomers, with an overall monomer composition by weight comprising polymerized units of 5 to 25 % by weight methacrylic acid and 75 to 95 % by weight of further monomers, wherein the further monomers are selected from C1- to C4-alkylesters of methacrylic acid and/or C1- to C4-alkylesters of acrylic acid, by stepwise or gradient emulsion polymerization, wherein the ratio by weight of polymerized units of methacrylic acid to further monomers is increasing stepwise or in a gradient from the center to the surface of the particles and wherein the polymeric particles are obtained in the form of an aqueous dispersion.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18210330 | 2018-12-05 | ||
PCT/EP2019/080788 WO2020114714A1 (en) | 2018-12-05 | 2019-11-11 | Process for preparing polymeric particles |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021006447A true MX2021006447A (en) | 2021-07-02 |
Family
ID=64959084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021006447A MX2021006447A (en) | 2018-12-05 | 2019-11-11 | Process for preparing polymeric particles. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220054421A1 (en) |
EP (1) | EP3891191A1 (en) |
JP (1) | JP2022511855A (en) |
KR (1) | KR20210099064A (en) |
CN (1) | CN113166287B (en) |
BR (1) | BR112021010623A2 (en) |
CA (1) | CA3121333A1 (en) |
IL (1) | IL283618A (en) |
MX (1) | MX2021006447A (en) |
WO (1) | WO2020114714A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2022307756A1 (en) | 2021-07-09 | 2024-02-22 | Evonik Operations Gmbh | Composition comprising a (meth)acrylate copolymer, an alkali or ammonium salt of a saturated aliphatic monocarboxylic acid and specific glidants |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE9414066U1 (en) | 1994-08-31 | 1994-11-03 | Röhm GmbH & Co. KG, 64293 Darmstadt | Coating and binding agents for pharmaceutical forms and pharmaceutical form produced therewith |
DE10260919A1 (en) * | 2002-12-20 | 2004-07-01 | Röhm GmbH & Co. KG | Process for the preparation of coated dosage forms and dietary supplements with concentration gradients in the coating |
DE102005007059A1 (en) * | 2005-02-15 | 2006-08-24 | Röhm GmbH & Co. KG | Partially neutralized anionic (meth) acrylate copolymer |
CN101696277B (en) * | 2009-10-27 | 2011-09-28 | 华南理工大学 | Redispersable acrylic ester polymer emulsion powder and preparation method thereof |
CA2839689C (en) | 2011-06-17 | 2018-05-01 | Evonik Roehm Gmbh | Coating composition suitable for pharmaceutical or nutraceutical dosage forms |
CN103160051B (en) * | 2011-12-16 | 2015-12-02 | 北京化工大学 | A kind of surface containing the polymer beads of tertiary amine groups as the purposes of thermal reversion reactive filler and composition thereof |
BR102014017358B1 (en) * | 2013-07-30 | 2020-06-02 | Rohm And Haas Company | STABLE AQUEOUS DISPERSION OF POLYMER PARTICLES, AND, METHOD |
ES2838816T3 (en) * | 2015-06-05 | 2021-07-02 | Evonik Operations Gmbh | Pharmaceutical or nutraceutical composition with resistance against the influence of ethanol |
FI128940B (en) * | 2015-09-04 | 2021-03-31 | Kemira Oyj | Core/shell polymer particles as surface sizing agents |
EP3248465A1 (en) * | 2016-05-25 | 2017-11-29 | Bayer CropScience Aktiengesellschaft | Agrochemical formulation based on emulsion polymers |
-
2019
- 2019-11-11 WO PCT/EP2019/080788 patent/WO2020114714A1/en unknown
- 2019-11-11 MX MX2021006447A patent/MX2021006447A/en unknown
- 2019-11-11 BR BR112021010623-5A patent/BR112021010623A2/en active Search and Examination
- 2019-11-11 EP EP19798103.8A patent/EP3891191A1/en active Pending
- 2019-11-11 CA CA3121333A patent/CA3121333A1/en active Pending
- 2019-11-11 CN CN201980080477.6A patent/CN113166287B/en active Active
- 2019-11-11 JP JP2021532084A patent/JP2022511855A/en not_active Withdrawn
- 2019-11-11 KR KR1020217020422A patent/KR20210099064A/en unknown
- 2019-11-11 US US17/309,498 patent/US20220054421A1/en not_active Abandoned
-
2021
- 2021-06-01 IL IL283618A patent/IL283618A/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20220054421A1 (en) | 2022-02-24 |
WO2020114714A1 (en) | 2020-06-11 |
KR20210099064A (en) | 2021-08-11 |
BR112021010623A2 (en) | 2021-09-14 |
EP3891191A1 (en) | 2021-10-13 |
IL283618A (en) | 2021-07-29 |
CN113166287B (en) | 2023-04-14 |
CA3121333A1 (en) | 2020-06-11 |
JP2022511855A (en) | 2022-02-01 |
CN113166287A (en) | 2021-07-23 |
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