MX2021005323A - Metodos de tratar la oftalmopatía de graves mediante el uso de anticuerpos anti-fcrn. - Google Patents

Metodos de tratar la oftalmopatía de graves mediante el uso de anticuerpos anti-fcrn.

Info

Publication number
MX2021005323A
MX2021005323A MX2021005323A MX2021005323A MX2021005323A MX 2021005323 A MX2021005323 A MX 2021005323A MX 2021005323 A MX2021005323 A MX 2021005323A MX 2021005323 A MX2021005323 A MX 2021005323A MX 2021005323 A MX2021005323 A MX 2021005323A
Authority
MX
Mexico
Prior art keywords
ophthalmopathy
methods
fcrn antibodies
fcrn
treating graves
Prior art date
Application number
MX2021005323A
Other languages
English (en)
Inventor
Regan Fong
Melissa Polasek
Christine Coquery
Original Assignee
Immunovant Sciences Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunovant Sciences Gmbh filed Critical Immunovant Sciences Gmbh
Publication of MX2021005323A publication Critical patent/MX2021005323A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

La presente descripción se refiere a composiciones, métodos y usos para usar un anticuerpo anti-FcRn aislado o un fragmento de unión a antígeno del mismo que se une al receptor de Fc neonatal (FcRn) para prevenir, modular o tratar la oftalmopatía de Graves.
MX2021005323A 2018-11-06 2019-11-05 Metodos de tratar la oftalmopatía de graves mediante el uso de anticuerpos anti-fcrn. MX2021005323A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862756472P 2018-11-06 2018-11-06
PCT/US2019/059894 WO2020097099A1 (en) 2018-11-06 2019-11-05 Methods of treating graves' ophthalmopathy using anti-fcrn antibodies

Publications (1)

Publication Number Publication Date
MX2021005323A true MX2021005323A (es) 2021-08-24

Family

ID=68655771

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021005323A MX2021005323A (es) 2018-11-06 2019-11-05 Metodos de tratar la oftalmopatía de graves mediante el uso de anticuerpos anti-fcrn.

Country Status (17)

Country Link
US (1) US20220002402A1 (es)
EP (1) EP3876985A1 (es)
JP (1) JP2022512967A (es)
KR (1) KR20210089214A (es)
CN (1) CN113423426A (es)
AU (1) AU2019374780A1 (es)
BR (1) BR112021008778A2 (es)
CA (1) CA3118777A1 (es)
CL (1) CL2021001201A1 (es)
CO (1) CO2021007053A2 (es)
EA (1) EA202191231A1 (es)
IL (1) IL282795A (es)
MX (1) MX2021005323A (es)
SG (1) SG11202104115SA (es)
TW (1) TW202031287A (es)
WO (1) WO2020097099A1 (es)
ZA (1) ZA202103035B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11926669B2 (en) 2022-05-30 2024-03-12 Hanall Biopharma Co., Ltd. Anti-FcRn antibody or antigen binding fragment thereof with improved stability
WO2024006942A1 (en) * 2022-06-29 2024-01-04 Lirum Therapeutics, Inc. Methods for treating inflammatory conditions of the eye with an igf-1r ligand conjugated to a disease- modifying agent
WO2024052357A1 (en) * 2022-09-06 2024-03-14 Immunovant Sciences Gmbh Methods of treating graves' disease using anti-fcrn antibodies
WO2024052358A1 (en) * 2022-09-06 2024-03-14 Immunovant Sciences Gmbh Methods of treating chronic inflammatory demyelinating polyneuropathy using anti-fcrn antibodies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201208370D0 (en) * 2012-05-14 2012-06-27 Ucb Pharma Sa Antibodies
EP3137504B1 (en) * 2014-04-30 2023-05-10 Hanall Biopharma Co., Ltd. Antibody binding to fcrn for treating autoimmune diseases
GB201508180D0 (en) * 2015-05-13 2015-06-24 Ucb Biopharma Sprl Antibodies

Also Published As

Publication number Publication date
US20220002402A1 (en) 2022-01-06
AU2019374780A1 (en) 2021-05-27
CA3118777A1 (en) 2020-05-14
CO2021007053A2 (es) 2021-08-19
WO2020097099A1 (en) 2020-05-14
CN113423426A (zh) 2021-09-21
EA202191231A1 (ru) 2021-10-11
CL2021001201A1 (es) 2022-02-11
JP2022512967A (ja) 2022-02-07
TW202031287A (zh) 2020-09-01
IL282795A (en) 2021-06-30
EP3876985A1 (en) 2021-09-15
BR112021008778A2 (pt) 2021-08-31
ZA202103035B (en) 2022-03-30
SG11202104115SA (en) 2021-05-28
KR20210089214A (ko) 2021-07-15

Similar Documents

Publication Publication Date Title
MX2021005323A (es) Metodos de tratar la oftalmopatía de graves mediante el uso de anticuerpos anti-fcrn.
MX2020007888A (es) Anticuerpos anti-tmprss2 y fragmentos de union a antigeno.
MX2021013681A (es) Moleculas de union a lag-3 y metodos de uso de las mismas.
CR20200579A (es) Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación
TN2019000272A1 (en) Anti-ilt4 antibodies and antigen-binding fragments.
EP4241852A3 (en) Antibody binding to fcrn for treating autoimmune diseases
EP3552665A3 (en) Antibodies
WO2019014328A3 (en) AGONISTIC ANTIBODIES THAT BIND HUMAN CD137 AND USES THEREOF
EA202091747A1 (ru) Составы антитела b7-h4
MX2020010094A (es) Kir3dl3 como receptor de hhla2, anticuerpos anti-hhla2 y usos de estos.
PH12020552006A1 (en) Antibodies specific for cd3 and uses thereof
PH12021550244A1 (en) Anti-btla antibody
JOP20190246A1 (ar) جسم مضاد أحادي النسيلة لـ pd-l1
CR20220078A (es) Anticuerpos anti-ms4a4a y métodos de uso de los mismos
MX2021012962A (es) Anticuerpo monoclonal que se une especificamente a gitr.
MX2022008255A (es) Anticuerpo anti-il-13 para usarse en el tratamiento de esofagitis eosinofilica.
MX2022005862A (es) Metodos de tratamiento de anemia hemolitica autoinmune caliente mediante el uso de anticuerpos anti-fcrn.
MX2022012628A (es) Anticuerpos anti-phf-tau y usos de estos.
MX2021000783A (es) Anticuerpos humanizados contra psma.
MX2021002750A (es) Anticuerpos anti-tnfrsf9 y usos de los mismos.
MX2021003119A (es) Anticuerpos anti-klrg1.
AU2018345715A8 (en) DNA monoclonal antibodies targeting CTLA-4 for the treatment and prevention of cancer
EP4218817A3 (en) Methods for treating metabolic diseases by inhibiting myostatin activation
MX2022002672A (es) Anticuerpo anti-vsig4 o fragmento de union a antigeno y usos del mismo.
MX2021015743A (es) Anticuerpos anti-angpt2.