MX2021000107A - Formas sólidas de 2-(3,5-dicloro-4-((5-isopropil-6-oxo-1,6-dihidro piridazin-3-il)oxi)fenil)-3,5-dioxo-2,3,4,5-tetrahidro-1,2,4-tria zin-6-carbonitrilo. - Google Patents

Formas sólidas de 2-(3,5-dicloro-4-((5-isopropil-6-oxo-1,6-dihidro piridazin-3-il)oxi)fenil)-3,5-dioxo-2,3,4,5-tetrahidro-1,2,4-tria zin-6-carbonitrilo.

Info

Publication number
MX2021000107A
MX2021000107A MX2021000107A MX2021000107A MX2021000107A MX 2021000107 A MX2021000107 A MX 2021000107A MX 2021000107 A MX2021000107 A MX 2021000107A MX 2021000107 A MX2021000107 A MX 2021000107A MX 2021000107 A MX2021000107 A MX 2021000107A
Authority
MX
Mexico
Prior art keywords
dioxo
tetrahydro
dichloro
oxy
oxo
Prior art date
Application number
MX2021000107A
Other languages
English (en)
Inventor
Mahmoud Mirmehrabi
Marco Jonas
Pavan Karthik Batchu
Original Assignee
Madrigal Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madrigal Pharmaceuticals Inc filed Critical Madrigal Pharmaceuticals Inc
Publication of MX2021000107A publication Critical patent/MX2021000107A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se relaciona a formas mórficas, cocristales, sales y dispersiones sólidas amorfas del 2-(3,5-dicloro-4-((5-isopropil-6-oxo-1,6-dihidropiridazin-3-il)ox i)fenil)-3,5-dioxo-2,3,4,5-tetrahidro-1,2,4-riazin-6-carbonitrilo .
MX2021000107A 2018-07-02 2019-07-02 Formas sólidas de 2-(3,5-dicloro-4-((5-isopropil-6-oxo-1,6-dihidro piridazin-3-il)oxi)fenil)-3,5-dioxo-2,3,4,5-tetrahidro-1,2,4-tria zin-6-carbonitrilo. MX2021000107A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862692914P 2018-07-02 2018-07-02
PCT/US2019/040276 WO2020010068A1 (en) 2018-07-02 2019-07-02 Solid forms of 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile

Publications (1)

Publication Number Publication Date
MX2021000107A true MX2021000107A (es) 2021-05-27

Family

ID=67441642

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2021000107A MX2021000107A (es) 2018-07-02 2019-07-02 Formas sólidas de 2-(3,5-dicloro-4-((5-isopropil-6-oxo-1,6-dihidro piridazin-3-il)oxi)fenil)-3,5-dioxo-2,3,4,5-tetrahidro-1,2,4-tria zin-6-carbonitrilo.
MX2023009701A MX2023009701A (es) 2018-07-02 2021-01-06 Formas solidas de 2-(3,5-dicloro-4-( (5-isopropil-6-oxo -1,6-dihidropiridazin-3-il) oxi) fenil)-3,5-dioxo -2,3,4,5-tetrahidro -1,2,4-triazina-6-carbonitrilo.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023009701A MX2023009701A (es) 2018-07-02 2021-01-06 Formas solidas de 2-(3,5-dicloro-4-( (5-isopropil-6-oxo -1,6-dihidropiridazin-3-il) oxi) fenil)-3,5-dioxo -2,3,4,5-tetrahidro -1,2,4-triazina-6-carbonitrilo.

Country Status (12)

Country Link
US (1) US20210122740A1 (es)
EP (1) EP3818057A1 (es)
JP (1) JP2021530456A (es)
KR (1) KR20210027454A (es)
CN (1) CN112638904A (es)
AR (1) AR115666A1 (es)
AU (1) AU2019298236A1 (es)
CA (1) CA3104860A1 (es)
IL (1) IL279700A (es)
MX (2) MX2021000107A (es)
TW (1) TW202019914A (es)
WO (1) WO2020010068A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3689853B1 (en) 2012-09-17 2021-11-24 Madrigal Pharmaceuticals, Inc. Method of synthesizing thyroid hormone analogs and polymorphs thereof
WO2018075650A1 (en) 2016-10-18 2018-04-26 Madrigal Pharmaceuticals, Inc. Methods of treating liver disorders or lipid disorders with a thr-beta agonist
WO2020169069A1 (en) 2019-02-21 2020-08-27 Nanjing Ruijie Pharma Co., Ltd. Novel compounds and their uses as thyroid hormone receptor agonists
US11091467B2 (en) 2019-05-08 2021-08-17 Aligos Therapeutics, Inc. Modulators of THR-β and methods of use thereof
WO2021063367A1 (zh) * 2019-09-30 2021-04-08 苏州科睿思制药有限公司 一种Resmetirom晶型及其制备方法和用途
CN114787153A (zh) * 2019-12-26 2022-07-22 苏州科睿思制药有限公司 一种Resmetirom晶型及其制备方法和用途
AU2021341182A1 (en) 2020-09-10 2023-04-27 Crystal Pharmaceutical (Suzhou) Co., Ltd. Crystal form of resmetirom, preparation method therefor, and use thereof
US20230364099A1 (en) 2020-10-19 2023-11-16 Teva Pharmaceuticals International Gmbh Solid state forms of resmetirom
CN114907327A (zh) * 2021-02-10 2022-08-16 杭州领业医药科技有限公司 Resmetirom的晶型及其制备方法和用途
WO2022225827A1 (en) * 2021-04-21 2022-10-27 Merck Sharp & Dohme Llc Novel forms of cyclic dinucleotide compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE480524T1 (de) * 2005-07-21 2010-09-15 Hoffmann La Roche Pyridazinonderivate als schilddrüsenhormon- rezeptoragonisten
EP3689853B1 (en) * 2012-09-17 2021-11-24 Madrigal Pharmaceuticals, Inc. Method of synthesizing thyroid hormone analogs and polymorphs thereof
WO2018075650A1 (en) * 2016-10-18 2018-04-26 Madrigal Pharmaceuticals, Inc. Methods of treating liver disorders or lipid disorders with a thr-beta agonist

Also Published As

Publication number Publication date
IL279700A (en) 2021-03-01
JP2021530456A (ja) 2021-11-11
EP3818057A1 (en) 2021-05-12
TW202019914A (zh) 2020-06-01
WO2020010068A1 (en) 2020-01-09
AR115666A1 (es) 2021-02-10
CN112638904A (zh) 2021-04-09
CA3104860A1 (en) 2020-01-09
MX2023009701A (es) 2023-08-29
US20210122740A1 (en) 2021-04-29
KR20210027454A (ko) 2021-03-10
AU2019298236A1 (en) 2021-01-21

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