MX2019010007A - Métodos para generar y separar por exclusión genotecas de péptidos compartimentados. - Google Patents
Métodos para generar y separar por exclusión genotecas de péptidos compartimentados.Info
- Publication number
- MX2019010007A MX2019010007A MX2019010007A MX2019010007A MX2019010007A MX 2019010007 A MX2019010007 A MX 2019010007A MX 2019010007 A MX2019010007 A MX 2019010007A MX 2019010007 A MX2019010007 A MX 2019010007A MX 2019010007 A MX2019010007 A MX 2019010007A
- Authority
- MX
- Mexico
- Prior art keywords
- compartmentalised
- polypeptide
- methods
- screening
- polynucleotide
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Un método para co-compartimentar un polipéptido cíclico con un polinucleótido que codifica el polipéptido cíclico, que comprende los pasos de a) formar un compartimento que contiene un polinucleótido que codifica el polipéptido cíclico, b) expresar un polipéptido a partir del polinucleótido, y c) ciclar el polipéptido. Polipéptidos cíclicos co-compartimentados y polinucleótidos codificadores. Bibliotecas de polipéptidos cíclicos compartimentados y polinucleótidos codificantes. Métodos para el rastreo de bibliotecas de polipéptidos cíclicos cocompartimentados y polinucleótidos codificantes. Incorporación de ácidos nucleicos no canónicos en dichas bibliotecas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1702938.0A GB201702938D0 (en) | 2017-02-23 | 2017-02-23 | Methods of generating and screening compartmentalised peptides libraries |
PCT/EP2018/054443 WO2018154021A1 (en) | 2017-02-23 | 2018-02-22 | Methods for generating and screening compartmentalised peptide libraries |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019010007A true MX2019010007A (es) | 2019-12-19 |
Family
ID=58544063
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019010007A MX2019010007A (es) | 2017-02-23 | 2018-02-22 | Métodos para generar y separar por exclusión genotecas de péptidos compartimentados. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20200049695A1 (es) |
EP (1) | EP3586134B1 (es) |
JP (1) | JP2020511432A (es) |
KR (1) | KR102567657B1 (es) |
CN (1) | CN110520729B (es) |
AU (1) | AU2018223899C1 (es) |
CA (1) | CA3054251A1 (es) |
ES (1) | ES2972599T3 (es) |
GB (1) | GB201702938D0 (es) |
MX (1) | MX2019010007A (es) |
WO (1) | WO2018154021A1 (es) |
ZA (1) | ZA201905538B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018165159A1 (en) * | 2017-03-06 | 2018-09-13 | Synvitrobio, Inc. | Methods and systems for cell-free biodiscovery of natural products |
WO2018225864A1 (ja) * | 2017-06-09 | 2018-12-13 | 中外製薬株式会社 | 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ |
CN110218776A (zh) * | 2019-06-14 | 2019-09-10 | 苏州叠代生物科技有限公司 | Pcr油相组合物及其制备方法 |
CN114902024A (zh) * | 2019-11-15 | 2022-08-12 | 闪璨迈璀公司 | 基于荧光团扩散的组合物和方法 |
WO2021174199A1 (en) * | 2020-02-28 | 2021-09-02 | Synvitrobio, Inc. | Methods and compositions for identifying traits using a cell-free system |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2260956T3 (es) * | 1998-12-18 | 2006-11-01 | The Penn State Research Foundation | Ciclacion de peptidos mediada por inteina. |
WO2001014539A2 (en) * | 1999-08-20 | 2001-03-01 | Johns Hopkins University School Of Medicine | Methods and compositions for the construction and use of fusion libraries |
EP1691792A4 (en) * | 2003-11-24 | 2008-05-28 | Yeda Res & Dev | COMPOSITIONS AND METHODS FOR IN VITRO / I SORTING OF MOLECULAR AND CELLULAR BANKS |
US7968287B2 (en) * | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
GB201108259D0 (en) * | 2011-05-17 | 2011-06-29 | Cambridge Entpr Ltd | Gel beads in microfluidic droplets |
JP6754997B2 (ja) * | 2013-08-26 | 2020-09-16 | 国立大学法人 東京大学 | 大環状ペプチド、その製造方法、及び大環状ペプチドライブラリを用いるスクリーニング方法 |
-
2017
- 2017-02-23 GB GBGB1702938.0A patent/GB201702938D0/en not_active Ceased
-
2018
- 2018-02-22 JP JP2019546242A patent/JP2020511432A/ja active Pending
- 2018-02-22 US US16/487,478 patent/US20200049695A1/en active Pending
- 2018-02-22 CN CN201880024950.4A patent/CN110520729B/zh active Active
- 2018-02-22 WO PCT/EP2018/054443 patent/WO2018154021A1/en unknown
- 2018-02-22 AU AU2018223899A patent/AU2018223899C1/en active Active
- 2018-02-22 MX MX2019010007A patent/MX2019010007A/es unknown
- 2018-02-22 EP EP18711230.5A patent/EP3586134B1/en active Active
- 2018-02-22 CA CA3054251A patent/CA3054251A1/en active Pending
- 2018-02-22 KR KR1020197027104A patent/KR102567657B1/ko active IP Right Grant
- 2018-02-22 ES ES18711230T patent/ES2972599T3/es active Active
-
2019
- 2019-08-22 ZA ZA2019/05538A patent/ZA201905538B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3586134C0 (en) | 2023-12-13 |
AU2018223899C1 (en) | 2024-03-28 |
US20200049695A1 (en) | 2020-02-13 |
KR102567657B1 (ko) | 2023-08-16 |
JP2020511432A (ja) | 2020-04-16 |
KR20190137078A (ko) | 2019-12-10 |
AU2018223899B2 (en) | 2023-11-30 |
CA3054251A1 (en) | 2018-08-30 |
ZA201905538B (en) | 2024-01-31 |
EP3586134A1 (en) | 2020-01-01 |
ES2972599T3 (es) | 2024-06-13 |
WO2018154021A1 (en) | 2018-08-30 |
CN110520729B (zh) | 2024-05-28 |
GB201702938D0 (en) | 2017-04-12 |
AU2018223899A1 (en) | 2019-09-12 |
EP3586134B1 (en) | 2023-12-13 |
CN110520729A (zh) | 2019-11-29 |
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