MX2019007950A - Tripeptide epoxy ketone protease inhibitors. - Google Patents

Tripeptide epoxy ketone protease inhibitors.

Info

Publication number
MX2019007950A
MX2019007950A MX2019007950A MX2019007950A MX2019007950A MX 2019007950 A MX2019007950 A MX 2019007950A MX 2019007950 A MX2019007950 A MX 2019007950A MX 2019007950 A MX2019007950 A MX 2019007950A MX 2019007950 A MX2019007950 A MX 2019007950A
Authority
MX
Mexico
Prior art keywords
protease inhibitors
epoxy ketone
ketone protease
tripeptide epoxy
compositions
Prior art date
Application number
MX2019007950A
Other languages
Spanish (es)
Inventor
Mcminn Dustin
Johnson Henry
Bowers Simeon
C Moebius David
Original Assignee
Onyx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51581125&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2019007950(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Onyx Therapeutics Inc filed Critical Onyx Therapeutics Inc
Publication of MX2019007950A publication Critical patent/MX2019007950A/en

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    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
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Abstract

Provided herein are tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X): and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of diseases including inflammation and neurodegenerative disease.
MX2019007950A 2013-03-14 2015-09-07 Tripeptide epoxy ketone protease inhibitors. MX2019007950A (en)

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