MX2019004299A - Peptidos derivados de fibronectina con bioactividad mejorada y sensibilidad reducida a la degradacion de la elastasa de neutrofilos. - Google Patents
Peptidos derivados de fibronectina con bioactividad mejorada y sensibilidad reducida a la degradacion de la elastasa de neutrofilos.Info
- Publication number
- MX2019004299A MX2019004299A MX2019004299A MX2019004299A MX2019004299A MX 2019004299 A MX2019004299 A MX 2019004299A MX 2019004299 A MX2019004299 A MX 2019004299A MX 2019004299 A MX2019004299 A MX 2019004299A MX 2019004299 A MX2019004299 A MX 2019004299A
- Authority
- MX
- Mexico
- Prior art keywords
- fibronectin
- neutrophil elastase
- peptides derived
- reduced susceptibility
- improved bioactivity
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000016359 Fibronectins Human genes 0.000 title abstract 2
- 108010067306 Fibronectins Proteins 0.000 title abstract 2
- 108010028275 Leukocyte Elastase Proteins 0.000 title abstract 2
- 102000016799 Leukocyte elastase Human genes 0.000 title abstract 2
- 230000015556 catabolic process Effects 0.000 title 1
- 238000006731 degradation reaction Methods 0.000 title 1
- 239000003102 growth factor Substances 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Se presentan los polipéptidos derivados de la fibronectina que son resistentes a la elastasa de neutrófilos y pueden unirse a factores de crecimiento y/o aumentar la actividad del factor de crecimiento. Estos polipéptidos son útiles para mejorar la cicatrización de heridas en un paciente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662408222P | 2016-10-14 | 2016-10-14 | |
PCT/US2017/056399 WO2018071709A1 (en) | 2016-10-14 | 2017-10-12 | Peptides derived from fibronectin with improved bioactivity and reduced susceptibility to neutrophil elastase degradation |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019004299A true MX2019004299A (es) | 2019-12-05 |
Family
ID=61906459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019004299A MX2019004299A (es) | 2016-10-14 | 2017-10-12 | Peptidos derivados de fibronectina con bioactividad mejorada y sensibilidad reducida a la degradacion de la elastasa de neutrofilos. |
Country Status (10)
Country | Link |
---|---|
US (2) | US11548935B2 (es) |
EP (1) | EP3526233A4 (es) |
JP (1) | JP6953537B2 (es) |
CN (1) | CN110023325B (es) |
AU (1) | AU2017343752B2 (es) |
BR (1) | BR112019007563A2 (es) |
CA (1) | CA3040467C (es) |
IL (1) | IL266023B2 (es) |
MX (1) | MX2019004299A (es) |
WO (1) | WO2018071709A1 (es) |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US860405A (en) | 1906-08-27 | 1907-07-16 | Hugh Mcchesley | Hoe. |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
US5051448A (en) | 1984-07-24 | 1991-09-24 | The Mclean Hospital Corporation | GABA esters and GABA analog esters |
DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
JP2594123B2 (ja) | 1987-09-12 | 1997-03-26 | 株式会社林原生物化学研究所 | 減感作剤 |
US5169862A (en) | 1989-07-07 | 1992-12-08 | Peptide Technologies Corporation | Analogs of viscosin and their uses |
US5192746A (en) | 1990-07-09 | 1993-03-09 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
US5559103A (en) | 1993-07-21 | 1996-09-24 | Cytel Corporation | Bivalent sialyl X saccharides |
US5539085A (en) | 1993-08-20 | 1996-07-23 | Onyx Pharmaceuticals, Inc. | Bcl-2 and R-ras complex |
US5576423A (en) | 1994-12-02 | 1996-11-19 | Schering Corporation | Antibodies to the slam protein expressed on activated T cells |
US6818209B1 (en) | 1998-05-22 | 2004-11-16 | Oxford Biomedica (Uk) Limited | Retroviral delivery system |
US6924123B2 (en) | 1996-10-29 | 2005-08-02 | Oxford Biomedica (Uk) Limited | Lentiviral LTR-deleted vector |
CA2366054A1 (en) | 1999-03-16 | 2000-09-21 | Wayne A. Marasco | Lentiviral vector system for high quantity screening |
WO2000072886A1 (en) | 1999-05-26 | 2000-12-07 | Dana-Farber Cancer Institute, Inc. | Episomally replicating lentiviral vectors |
WO2001066565A2 (en) | 2000-03-06 | 2001-09-13 | Rigel Pharmaceuticals, Inc. | In vivo production of cyclic peptides |
WO2002090377A2 (en) | 2001-05-07 | 2002-11-14 | Tufts University | Peptides that bind to dna and inhibit dna replication, and methods of use |
US6863884B2 (en) | 2002-05-01 | 2005-03-08 | Cell Genesys, Inc. | Pseudotyped retroviral vectors |
US6799657B2 (en) | 2002-10-02 | 2004-10-05 | Carrier Corporation | Absorptive/reactive muffler for variable speed compressors |
FR2854897B1 (fr) | 2003-05-12 | 2007-05-04 | Sederma Sa | Compositions cosmetiques ou dermopharmaceutiques pour reduire les signes du vieillissement cutane. |
AU2004249165A1 (en) | 2003-06-17 | 2004-12-29 | Cognis Deutschland Gmbh & Co. Kg | Modified soy proteins in skin tightening compositions |
CA2530407A1 (en) | 2003-07-23 | 2005-02-03 | The Regents Of The University Of California | Penetration enhancer combinations for transdermal delivery |
US20050282747A1 (en) | 2003-10-01 | 2005-12-22 | The Research Foundation Of State University Of New York At Stony Brook | Methods and compositions for wound healing |
DK1755660T3 (da) * | 2004-05-07 | 2010-07-19 | Univ North Carolina | Fremgangsmåde til forbedring eller hæmning af insulin-lignende vækstfaktor-I |
US8691944B2 (en) | 2005-10-04 | 2014-04-08 | The Research Foundation For The State University Of New York | Fibronectin polypeptides and methods of use |
CA2690734A1 (en) | 2007-06-14 | 2008-12-24 | Richard A. Clark | Polypeptides and methods of use |
NZ600454A (en) * | 2009-11-30 | 2014-10-31 | Univ Queensland | Fibronectin: growth factor chimeras |
DK3690056T5 (da) * | 2014-01-31 | 2024-08-26 | Factor Bioscience Inc | Fremgangsmåder og produkter til fremstilling og indgivelse af nukleinsyre |
-
2017
- 2017-10-12 EP EP17859564.1A patent/EP3526233A4/en active Pending
- 2017-10-12 IL IL266023A patent/IL266023B2/en unknown
- 2017-10-12 CN CN201780073465.1A patent/CN110023325B/zh active Active
- 2017-10-12 BR BR112019007563A patent/BR112019007563A2/pt unknown
- 2017-10-12 CA CA3040467A patent/CA3040467C/en active Active
- 2017-10-12 MX MX2019004299A patent/MX2019004299A/es unknown
- 2017-10-12 US US16/341,686 patent/US11548935B2/en active Active
- 2017-10-12 JP JP2019541675A patent/JP6953537B2/ja active Active
- 2017-10-12 WO PCT/US2017/056399 patent/WO2018071709A1/en unknown
- 2017-10-12 AU AU2017343752A patent/AU2017343752B2/en active Active
-
2022
- 2022-11-22 US US18/057,898 patent/US20230331814A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2020500208A (ja) | 2020-01-09 |
CN110023325B (zh) | 2023-07-04 |
EP3526233A1 (en) | 2019-08-21 |
IL266023B2 (en) | 2024-07-01 |
AU2017343752B2 (en) | 2021-12-16 |
WO2018071709A1 (en) | 2018-04-19 |
EP3526233A4 (en) | 2020-03-18 |
CA3040467C (en) | 2023-10-31 |
NZ752999A (en) | 2022-03-25 |
US11548935B2 (en) | 2023-01-10 |
US20230331814A1 (en) | 2023-10-19 |
CN110023325A (zh) | 2019-07-16 |
IL266023B1 (en) | 2024-03-01 |
US20200223903A1 (en) | 2020-07-16 |
BR112019007563A2 (pt) | 2019-07-02 |
IL266023A (en) | 2019-06-30 |
AU2017343752A1 (en) | 2019-05-23 |
CA3040467A1 (en) | 2018-04-19 |
JP6953537B2 (ja) | 2021-10-27 |
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