MX2019003618A - Pyrimidinyl tyrosine kinase inhibitors. - Google Patents

Pyrimidinyl tyrosine kinase inhibitors.

Info

Publication number
MX2019003618A
MX2019003618A MX2019003618A MX2019003618A MX2019003618A MX 2019003618 A MX2019003618 A MX 2019003618A MX 2019003618 A MX2019003618 A MX 2019003618A MX 2019003618 A MX2019003618 A MX 2019003618A MX 2019003618 A MX2019003618 A MX 2019003618A
Authority
MX
Mexico
Prior art keywords
tyrosine kinase
kinase inhibitors
pyrimidinyl
pyrimidinyl tyrosine
inhibitors
Prior art date
Application number
MX2019003618A
Other languages
Spanish (es)
Inventor
Conlon Patrick
R Chan Timothy
Humora Michael
A Miller Ross
Thompson Andrew
T Hopkins Brian
J Jenkins Tracy
Cai Xiongwei
Shi Xianglin
Original Assignee
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Ma Inc filed Critical Biogen Ma Inc
Publication of MX2019003618A publication Critical patent/MX2019003618A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Abstract

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
MX2019003618A 2012-06-08 2014-12-08 Pyrimidinyl tyrosine kinase inhibitors. MX2019003618A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261657360P 2012-06-08 2012-06-08

Publications (1)

Publication Number Publication Date
MX2019003618A true MX2019003618A (en) 2019-07-18

Family

ID=49712704

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014015044A MX363672B (en) 2012-06-08 2013-06-07 Pyrimidinyl tyrosine kinase inhibitors.
MX2019003618A MX2019003618A (en) 2012-06-08 2014-12-08 Pyrimidinyl tyrosine kinase inhibitors.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2014015044A MX363672B (en) 2012-06-08 2013-06-07 Pyrimidinyl tyrosine kinase inhibitors.

Country Status (30)

Country Link
US (5) US9394277B2 (en)
EP (3) EP3385263B1 (en)
JP (6) JP6214643B2 (en)
KR (4) KR102468430B1 (en)
CN (3) CN109305959B (en)
AR (1) AR091273A1 (en)
AU (5) AU2013271407B2 (en)
BR (2) BR112014030655B1 (en)
CA (2) CA2875799C (en)
CY (1) CY1120638T1 (en)
DK (1) DK2858499T3 (en)
EA (2) EA201790418A1 (en)
ES (2) ES2684268T3 (en)
HK (1) HK1209284A1 (en)
HR (1) HRP20181294T1 (en)
HU (1) HUE039897T2 (en)
IL (2) IL235938B (en)
IN (1) IN2014DN10576A (en)
LT (1) LT2858499T (en)
MX (2) MX363672B (en)
NZ (1) NZ702715A (en)
PH (2) PH12014502699B1 (en)
PL (1) PL2858499T3 (en)
PT (1) PT2858499T (en)
RS (1) RS57978B1 (en)
SG (2) SG11201408173WA (en)
SI (1) SI2858499T1 (en)
TW (3) TWI592406B (en)
WO (1) WO2013185084A1 (en)
ZA (1) ZA201409255B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2473049T3 (en) 2009-09-04 2019-07-31 Biogen Ma Inc. Bruton's tyrosine kinase inhibitors
WO2012058645A1 (en) 2010-10-29 2012-05-03 Biogen Idec Ma Inc. Heterocyclic tyrosine kinase inhibitors
AR091273A1 (en) 2012-06-08 2015-01-21 Biogen Idec Inc PYRIMIDINYL TIROSINE KINASE INHIBITORS
US9353087B2 (en) 2012-06-08 2016-05-31 Biogen Ma Inc. Inhibitors of Bruton's tyrosine kinase
RS57662B1 (en) * 2013-12-11 2018-11-30 Biogen Ma Inc Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology
WO2015151006A1 (en) 2014-03-29 2015-10-08 Lupin Limited Substituted purine compounds as btk inhibitors
WO2015170266A1 (en) 2014-05-07 2015-11-12 Lupin Limited Substituted pyrimidine compounds as btk inhibitors
CA2965517C (en) * 2014-10-24 2023-05-02 Bristol-Myers Squibb Company Indole carboxamides compounds useful as kinase inhibitors
KR20190035769A (en) * 2016-07-21 2019-04-03 바이오젠 엠에이 인코포레이티드 The form and composition of succinate of Brutonyl tyrosine kinase inhibitor
US20210113568A1 (en) 2018-04-27 2021-04-22 Ono Pharmaceutical Co., Ltd. PREVENTIVE AND/OR THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASE COMPRISING COMPOUND HAVING Btk INHIBITORY ACTIVITY AS ACTIVE INGREDIENT
CA3224949A1 (en) 2018-07-31 2020-02-06 Loxo Oncology, Inc. Spray-dried dispersions, formulations, and polymorphs of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1h-pyrazole-4-carboxamide
WO2020188015A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
WO2021089791A1 (en) 2019-11-08 2021-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
US20240100172A1 (en) 2020-12-21 2024-03-28 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
WO2022212893A1 (en) 2021-04-02 2022-10-06 Biogen Ma Inc. Combination treatment methods of multiple sclerosis
WO2023081715A1 (en) 2021-11-03 2023-05-11 Viracta Therapeutics, Inc. Combination of car t-cell therapy with btk inhibitors and methods of use thereof
WO2023081709A1 (en) 2021-11-03 2023-05-11 Viracta Therapeutics, Inc. Vecabrutinib for the treatment of graft-versus-host disease
WO2023110970A1 (en) 2021-12-14 2023-06-22 Netherlands Translational Research Center Holding B.V Macrocyclic btk inhibitors

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1624A (en) * 1840-06-10 Cooking-stove
US4528138A (en) 1984-06-20 1985-07-09 E. R. Squibb & Sons, Inc. 16-Keto-17-substituted thia-17-alkyl(or alkenyl or alkynyl) androstenes
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (en) 1985-10-03 1988-12-02 Merck Sharp & Dohme LIQUID-GEL PHASE TRANSITION PHARMACEUTICAL COMPOSITION
EP0495421B1 (en) 1991-01-15 1996-08-21 Alcon Laboratories, Inc. Use of carrageenans in topical ophthalmic compositions
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
PA8474101A1 (en) 1998-06-19 2000-09-29 Pfizer Prod Inc PYROLEUM [2,3-D] PIRIMIDINE COMPOUNDS
US6919178B2 (en) 2000-11-21 2005-07-19 Sunesis Pharmaceuticals, Inc. Extended tethering approach for rapid identification of ligands
AU2001250849A1 (en) 2000-03-17 2001-10-03 Bristol-Myers Squibb Pharma Company Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha
MY137020A (en) 2000-04-27 2008-12-31 Abbott Lab Diazabicyclic central nervous system active agents
EP1294724B1 (en) 2000-06-26 2006-04-19 Pfizer Products Inc. Pyrrolo¬2,3-d|pyrimidine compounds as immunosuppressive agents
PE20020507A1 (en) * 2000-10-17 2002-06-25 Schering Corp NON-IMIDAZOLE COMPOUNDS AS ANTAGONISTS OF THE HISTAMINE H3 RECEPTOR
US20050143372A1 (en) * 2001-10-30 2005-06-30 Shomir Ghosh Compounds, pharmaceutical compositions and methods of use therefor
JP2005515173A (en) 2001-10-31 2005-05-26 バイエル・ヘルスケア・アクチェンゲゼルシャフト Pyrimido [4,5-b] indole derivatives
DE602004009295T2 (en) 2003-01-14 2008-07-03 Arena Pharmaceuticals, Inc., San Diego 1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM FOR THE PREVENTION AND TREATMENT OF METABOLISM-CONDITIONAL DISEASES SUCH AS DIABETES OR HYPERGLYKEMIA
SI1678166T1 (en) 2003-10-14 2009-10-31 Univ Arizona State Protein kinase inhibitors
EP1778298A4 (en) * 2004-04-01 2010-03-31 Univ Pennsylvania Lipoprotein nanoplatforms
EP1750727A2 (en) 2004-04-23 2007-02-14 Exelixis, Inc. Kinase modulators and methods of use
FR2870541B1 (en) 2004-05-18 2006-07-14 Proskelia Sas ANTIGONISTIC PYRIMIDINE DERIVATIVES OF VITRONECTIN RECEPTOR
TW200621760A (en) 2004-09-09 2006-07-01 Mitsubishi Pharma Corp 2-morpholino-4-pyrimidone compound
NZ555236A (en) * 2004-11-04 2010-10-29 Vertex Pharma Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
KR101351209B1 (en) 2004-12-03 2014-02-06 머크 샤프 앤드 돔 코포레이션 Substituted piperazines as CB1 antagonists
CA2590961C (en) 2004-12-28 2013-11-26 Exelixis, Inc. [1h-pyrazolo[3,4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-threonine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases
US7880002B2 (en) 2004-12-29 2011-02-01 Millennium Pharmaceuticals, Inc. Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists
WO2006091450A1 (en) * 2005-02-18 2006-08-31 Lexicon Genetics Incorporated 4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds
US20060281764A1 (en) 2005-06-10 2006-12-14 Gaul Michael D Aminopyrimidines as kinase modulators
US20060281700A1 (en) 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using aminopyrimidines kinase modulators
TW200740779A (en) 2005-07-22 2007-11-01 Mitsubishi Pharma Corp Intermediate compound for synthesizing pharmaceutical agent and production method thereof
JP5191391B2 (en) 2005-11-01 2013-05-08 ターゲジェン インコーポレーティッド Bi-aryl meta-pyrimidine inhibitors of kinases
CN101378807A (en) * 2005-12-21 2009-03-04 先灵公司 Combination of an H3 antagonist/inverse agonist and an appetite suppressant
US20080076924A1 (en) 2006-06-30 2008-03-27 Patrick Betschmann Piperazines as P2X7 antagonists
WO2008012635A2 (en) 2006-07-26 2008-01-31 Pfizer Products Inc. Amine derivatives useful as anticancer agents
EP2059305A2 (en) 2006-07-26 2009-05-20 Novartis Ag Inhibitors of undecaprenyl pyrophosphate synthase
US20100160292A1 (en) 2006-09-11 2010-06-24 Cgi Pharmaceuticals, Inc Kinase Inhibitors, and Methods of Using and Identifying Kinase Inhibitors
SI2526934T1 (en) 2006-09-22 2016-04-29 Pharmacyclics Llc Inhibitors of bruton's tyrosine kinase
AR065494A1 (en) * 2007-03-02 2009-06-10 Schering Corp PIPERIDINE DERIVATIVES AND METHODS OF USE OF THE SAME
WO2008116064A2 (en) 2007-03-21 2008-09-25 Bristol-Myers Squibb Company Fused heterocyclic compounds useful for the treatment of proliferative, allergic, autoimmune or inflammatory diseases
WO2008144253A1 (en) 2007-05-14 2008-11-27 Irm Llc Protein kinase inhibitors and methods for using thereof
JP5291095B2 (en) 2007-06-01 2013-09-18 グラクソスミスクライン エルエルシー Imidazopyridine kinase inhibitor
RU2505538C2 (en) * 2008-02-05 2014-01-27 Ф.Хоффманн-Ля Рош Аг Novel pyridinones and pyridazinones
ES2542066T3 (en) 2008-04-29 2015-07-30 Immunexcite, Inc. Immunomodulatory compositions and methods of use thereof
AU2009270856B2 (en) 2008-07-16 2013-07-25 Pharmacyclics Llc Inhibitors of Bruton's tyrosine kinase for the treatment of solid tumors
WO2010068788A1 (en) * 2008-12-10 2010-06-17 Cgi Pharmaceuticals, Inc. Heterocyclic amides as btk inhibitors
KR20110098827A (en) * 2008-12-19 2011-09-01 브리스톨-마이어스 스큅 컴퍼니 Carbazole carboxamide compounds useful as kinase inhibitors
WO2010080712A2 (en) * 2009-01-06 2010-07-15 Dana Farber Cancer Institute Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
EP2435442B1 (en) 2009-05-25 2016-01-13 Sandoz AG Method for producing ceftobiprol medocaril
EP2485589A4 (en) 2009-09-04 2013-02-06 Biogen Idec Inc Heteroaryl btk inhibitors
PL2473049T3 (en) 2009-09-04 2019-07-31 Biogen Ma Inc. Bruton's tyrosine kinase inhibitors
US8685880B2 (en) 2010-06-30 2014-04-01 Chevron U.S.A. Inc. On-site drying of aqueous salt for ionic liquid make-up
WO2012058645A1 (en) 2010-10-29 2012-05-03 Biogen Idec Ma Inc. Heterocyclic tyrosine kinase inhibitors
US9353087B2 (en) 2012-06-08 2016-05-31 Biogen Ma Inc. Inhibitors of Bruton's tyrosine kinase
AR091273A1 (en) * 2012-06-08 2015-01-21 Biogen Idec Inc PYRIMIDINYL TIROSINE KINASE INHIBITORS
EP3444251B1 (en) 2013-12-11 2023-06-07 Biogen MA Inc. Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology
RS57662B1 (en) 2013-12-11 2018-11-30 Biogen Ma Inc Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology
US20170298446A1 (en) 2014-10-03 2017-10-19 Ohio State Innovation Foundation Biomarkers of bruton tyrosine kinase inhibitor resistance

Also Published As

Publication number Publication date
EA201492056A1 (en) 2015-05-29
MX363672B (en) 2019-03-29
PL2858499T3 (en) 2019-03-29
AU2017201536B2 (en) 2019-03-07
SG11201408173WA (en) 2015-01-29
MX2014015044A (en) 2015-09-22
SG10201708535UA (en) 2017-11-29
AU2019203476A1 (en) 2019-06-06
KR102468430B1 (en) 2022-11-21
EP3753934A1 (en) 2020-12-23
AU2021202412A1 (en) 2021-05-20
BR122021002178B1 (en) 2022-03-22
IL235938A0 (en) 2015-02-01
KR20200043497A (en) 2020-04-27
IL235938B (en) 2020-10-29
AU2022275504A1 (en) 2023-01-05
TWI592406B (en) 2017-07-21
IN2014DN10576A (en) 2015-08-28
NZ702715A (en) 2016-11-25
CA2875799C (en) 2021-03-23
CN109305959A (en) 2019-02-05
TW202142535A (en) 2021-11-16
PH12018501463A1 (en) 2019-03-04
US20210017155A1 (en) 2021-01-21
AU2019203476B2 (en) 2021-01-28
RS57978B1 (en) 2019-01-31
TW201805279A (en) 2018-02-16
TWI792158B (en) 2023-02-11
KR20150036020A (en) 2015-04-07
JP2021073299A (en) 2021-05-13
BR112014030655A8 (en) 2018-01-02
DK2858499T3 (en) 2018-08-20
CA3108186A1 (en) 2013-12-12
JP2019077728A (en) 2019-05-23
US20190047986A1 (en) 2019-02-14
PH12014502699A1 (en) 2015-02-02
TWI719209B (en) 2021-02-21
JP6214643B2 (en) 2017-10-18
JP2023052415A (en) 2023-04-11
CA2875799A1 (en) 2013-12-12
AR091273A1 (en) 2015-01-21
AU2013271407B2 (en) 2016-12-08
SI2858499T1 (en) 2018-10-30
CN104540385B (en) 2018-06-05
LT2858499T (en) 2018-09-10
EP3385263B1 (en) 2020-07-22
JP2017193583A (en) 2017-10-26
EP2858499A4 (en) 2016-01-20
IL277951A (en) 2020-11-30
EP2858499A1 (en) 2015-04-15
EA201790418A1 (en) 2017-11-30
WO2013185084A1 (en) 2013-12-12
EA027823B1 (en) 2017-09-29
ZA201409255B (en) 2015-12-23
BR112014030655A2 (en) 2017-06-27
US9944622B2 (en) 2018-04-17
JP2015518903A (en) 2015-07-06
HUE039897T2 (en) 2019-02-28
KR20220154850A (en) 2022-11-22
CN109305959B (en) 2022-02-08
PT2858499T (en) 2018-10-24
EP3385263A1 (en) 2018-10-10
KR102102587B1 (en) 2020-04-22
KR20210072139A (en) 2021-06-16
JP2021073298A (en) 2021-05-13
ES2834333T3 (en) 2021-06-17
ES2684268T3 (en) 2018-10-02
CY1120638T1 (en) 2019-12-11
US10618887B2 (en) 2020-04-14
AU2013271407A1 (en) 2015-01-22
CN104540385A (en) 2015-04-22
EP2858499B1 (en) 2018-05-16
AU2017201536A1 (en) 2017-03-23
US20230174511A1 (en) 2023-06-08
PH12014502699B1 (en) 2015-02-02
CN113549055A (en) 2021-10-26
US20150158843A1 (en) 2015-06-11
BR112014030655B1 (en) 2021-04-20
US20160304494A1 (en) 2016-10-20
TW201410668A (en) 2014-03-16
HRP20181294T1 (en) 2018-10-05
US9394277B2 (en) 2016-07-19
HK1209284A1 (en) 2016-04-01

Similar Documents

Publication Publication Date Title
PH12018501463A1 (en) Pyrimidinyl tyrosine kinase inhibitors
MY179781A (en) Biaryl inhibitors of bruton's tyrosine kinase
AU2018236800B2 (en) DNA-PK inhibitors
TW201713640A (en) Bruton's tyrosine kinase inhibitors
WO2013185082A3 (en) Inhibitors of bruton's tyrosine kinase
NZ700928A (en) Dna-pk inhibitors
PH12015502041B1 (en) Heteroaryl compounds and uses thereof
IN2014DN09346A (en)
MX368455B (en) Tetrahydropyrazolopyrimidine compounds.
MX2014010849A (en) Solid forms of an epidermal growth factor receptor kinase inhibitor.
IN2015DN00127A (en)
IL259863B (en) Polycyclic compounds as inhibitors of bruton's tyrosine kinase
EA201590268A1 (en) ARYLACTAM KINASE INHIBITORS
MX2019000884A (en) Succinate forms and compositions of bruton's tyrosine kinase inhibitors.
NZ743260A (en) Bipiperidine-2-one compounds for the preparation of pyrimidinyl tyrosine kinase inhibitors
NZ737572A (en) Intermediate compounds for the preparation of bipiperidine-2-one compounds