MX2018015542A - Expresion de proteinas de ligando activadoras de nkg2d para la sensibilizacion de celulas cancerosas para el ataque por celulas inmunocitotoxicas. - Google Patents
Expresion de proteinas de ligando activadoras de nkg2d para la sensibilizacion de celulas cancerosas para el ataque por celulas inmunocitotoxicas.Info
- Publication number
- MX2018015542A MX2018015542A MX2018015542A MX2018015542A MX2018015542A MX 2018015542 A MX2018015542 A MX 2018015542A MX 2018015542 A MX2018015542 A MX 2018015542A MX 2018015542 A MX2018015542 A MX 2018015542A MX 2018015542 A MX2018015542 A MX 2018015542A
- Authority
- MX
- Mexico
- Prior art keywords
- vector
- expression
- cancer
- cells
- activating ligand
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title abstract 9
- 206010028980 Neoplasm Diseases 0.000 title abstract 7
- 201000011510 cancer Diseases 0.000 title abstract 7
- 239000003446 ligand Substances 0.000 title abstract 5
- 230000003213 activating effect Effects 0.000 title abstract 4
- 231100000433 cytotoxic Toxicity 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
- 210000002865 immune cell Anatomy 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 230000001235 sensitizing effect Effects 0.000 title 1
- 239000013598 vector Substances 0.000 abstract 5
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 abstract 3
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 abstract 3
- 102000012011 Isocitrate Dehydrogenase Human genes 0.000 abstract 2
- 108010075869 Isocitrate Dehydrogenase Proteins 0.000 abstract 2
- 230000003013 cytotoxicity Effects 0.000 abstract 2
- 231100000135 cytotoxicity Toxicity 0.000 abstract 2
- 239000012636 effector Substances 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 208000032612 Glial tumor Diseases 0.000 abstract 1
- 206010018338 Glioma Diseases 0.000 abstract 1
- 241000700584 Simplexvirus Species 0.000 abstract 1
- 108091008324 binding proteins Proteins 0.000 abstract 1
- 102000023732 binding proteins Human genes 0.000 abstract 1
- 208000005017 glioblastoma Diseases 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 108091070501 miRNA Proteins 0.000 abstract 1
- 239000002679 microRNA Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 230000000174 oncolytic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000013603 viral vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16632—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662350095P | 2016-06-14 | 2016-06-14 | |
| PCT/US2017/037531 WO2017218689A1 (en) | 2016-06-14 | 2017-06-14 | Expression of nkg2d activating ligand proteins for sensitizing cancer cells to attack by cytotoxic immune cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018015542A true MX2018015542A (es) | 2019-10-14 |
Family
ID=60664263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018015542A MX2018015542A (es) | 2016-06-14 | 2017-06-14 | Expresion de proteinas de ligando activadoras de nkg2d para la sensibilizacion de celulas cancerosas para el ataque por celulas inmunocitotoxicas. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11427625B2 (enExample) |
| EP (1) | EP3468588A4 (enExample) |
| JP (1) | JP7184337B2 (enExample) |
| CN (1) | CN109475613B (enExample) |
| AU (1) | AU2017285213B2 (enExample) |
| CA (1) | CA3027857C (enExample) |
| MX (1) | MX2018015542A (enExample) |
| NZ (1) | NZ749586A (enExample) |
| WO (1) | WO2017218689A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020000993A (es) | 2017-07-26 | 2020-07-22 | Oncorus Inc | Vectores virales oncolíticos y usos de estos. |
| WO2019032628A1 (en) | 2017-08-07 | 2019-02-14 | The Regents Of The University Of California | GENERATING PLATFORM FOR SAFE CELLULAR THERAPEUTIC AGENTS |
| SG11202101581RA (en) * | 2017-08-09 | 2021-03-30 | Ohio State Innovation Foundation | Oncolytic virus carrying e-cadherin and uses thereof |
| US12036256B2 (en) * | 2018-04-13 | 2024-07-16 | Regeneron Pharmaceuticals, Inc. | Adoptive cellular therapy |
| EP3874041A1 (en) * | 2018-11-01 | 2021-09-08 | Onconetics Pharmaceuticals, Inc. | Multi-component vector systems, methods of making, and uses thereof |
| TW202038947A (zh) | 2018-11-28 | 2020-11-01 | 德商創新分子有限責任公司 | 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑 |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| EP4061405A1 (en) | 2019-11-18 | 2022-09-28 | Janssen Biotech, Inc. | Vaccines based on mutant calr and jak2 and their uses |
| EP4175664A2 (en) | 2020-07-06 | 2023-05-10 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| WO2022009049A1 (en) | 2020-07-06 | 2022-01-13 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| AU2022255538B2 (en) * | 2021-04-08 | 2026-01-22 | Immvira Biopharmaceuticals Co., Limited | Genetically modified oncolytic herpes simplex virus delivering chemokine and tumor associated/specific antigen |
| WO2025245495A1 (en) * | 2024-05-24 | 2025-11-27 | Cz Biohub Sf, Llc | Selective sensitization of cancer cells to elimination by cytotoxic lymphocytes |
| CN118389408B (zh) * | 2024-06-26 | 2024-11-29 | 淇嘉科技(苏州)有限公司 | 炎症性肠病及纤维化体外精准模拟方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999031241A1 (en) | 1997-12-17 | 1999-06-24 | Immunex Corporation | Cell surface glycoproteins associated with human b cell lymphomas - ulbp, dna and polypeptides |
| JP2005523681A (ja) | 2001-10-04 | 2005-08-11 | イミュネックス・コーポレーション | Ｕｌ１６結合タンパク質４ |
| US20150165065A1 (en) | 2009-12-31 | 2015-06-18 | Avidbiotics Corp. | Non-natural mic proteins |
| WO2012006181A2 (en) | 2010-06-29 | 2012-01-12 | Mount Sinai School Of Medicine | Compositions and methods for inhibiting oncogenic micrornas and treatment of cancer |
| US20130156808A1 (en) | 2011-11-22 | 2013-06-20 | Stipan Jonjic | Vaccine comprising beta-herpesvirus |
| DK3184641T3 (da) * | 2013-10-28 | 2020-08-03 | Univ Of Pittsburgh - Of The Commonwealth System Of Higher Education | Onkolytisk hsv-vektor |
-
2017
- 2017-06-14 MX MX2018015542A patent/MX2018015542A/es unknown
- 2017-06-14 NZ NZ749586A patent/NZ749586A/en unknown
- 2017-06-14 CA CA3027857A patent/CA3027857C/en active Active
- 2017-06-14 AU AU2017285213A patent/AU2017285213B2/en active Active
- 2017-06-14 WO PCT/US2017/037531 patent/WO2017218689A1/en not_active Ceased
- 2017-06-14 US US16/309,862 patent/US11427625B2/en active Active
- 2017-06-14 CN CN201780036512.5A patent/CN109475613B/zh active Active
- 2017-06-14 EP EP17814031.5A patent/EP3468588A4/en not_active Withdrawn
- 2017-06-14 JP JP2018566257A patent/JP7184337B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3468588A1 (en) | 2019-04-17 |
| CN109475613A (zh) | 2019-03-15 |
| EP3468588A4 (en) | 2019-12-11 |
| CN109475613B (zh) | 2024-02-20 |
| WO2017218689A1 (en) | 2017-12-21 |
| US11427625B2 (en) | 2022-08-30 |
| JP7184337B2 (ja) | 2022-12-06 |
| NZ749586A (en) | 2023-06-30 |
| AU2017285213A1 (en) | 2019-01-17 |
| JP2019517815A (ja) | 2019-06-27 |
| AU2017285213B2 (en) | 2024-05-16 |
| CA3027857C (en) | 2023-07-25 |
| US20200148742A1 (en) | 2020-05-14 |
| CA3027857A1 (en) | 2017-12-21 |
| WO2017218689A9 (en) | 2018-12-13 |
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