MX2018013070A - Pharmaceutical combination comprising extended-release tramadol hydrochloride and immediate-release etoricoxib, and its use for the treatment of pain. - Google Patents

Pharmaceutical combination comprising extended-release tramadol hydrochloride and immediate-release etoricoxib, and its use for the treatment of pain.

Info

Publication number
MX2018013070A
MX2018013070A MX2018013070A MX2018013070A MX2018013070A MX 2018013070 A MX2018013070 A MX 2018013070A MX 2018013070 A MX2018013070 A MX 2018013070A MX 2018013070 A MX2018013070 A MX 2018013070A MX 2018013070 A MX2018013070 A MX 2018013070A
Authority
MX
Mexico
Prior art keywords
release
pain
pharmaceutical combination
etoricoxib
tramadol hydrochloride
Prior art date
Application number
MX2018013070A
Other languages
Spanish (es)
Inventor
Pattaro Marcondes Lizandra
Lastenia RODRIGUEZ FLORES Maria
Estefania Oleas Recalde Mishel
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MX2018013070A publication Critical patent/MX2018013070A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A pharmaceutical combination comprising: i) a first formulation of extended- release tramadol hydrochloride containing from 2.0% to 12.0% w/w of tramadol hydrochloride, and ii) a second formulation of immediate-release etoricoxib containing from 6.0% to 18% w/w of etoricoxib, solvents or carrier; manufacturing process to prepare the pharmaceutical combination and the individual formulations, wherein the combination is presented in a single dosage form such as, capsules, tablets, bilayer tablets, granulates and sachets. The present invention provides methods of preventing and treating pain, such as acute pain, and the use of the pharmaceutical combination for the prevention and treatment of pain, such as acute pain.
MX2018013070A 2017-12-29 2017-12-29 Pharmaceutical combination comprising extended-release tramadol hydrochloride and immediate-release etoricoxib, and its use for the treatment of pain. MX2018013070A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2017/058519 WO2019130049A1 (en) 2017-12-29 2017-12-29 Pharmaceutical combination comprising extended-release tramadol hydrochloride and immediate-release etoricoxib, and its use for the treatment of pain

Publications (1)

Publication Number Publication Date
MX2018013070A true MX2018013070A (en) 2019-10-15

Family

ID=61024811

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018013070A MX2018013070A (en) 2017-12-29 2017-12-29 Pharmaceutical combination comprising extended-release tramadol hydrochloride and immediate-release etoricoxib, and its use for the treatment of pain.

Country Status (4)

Country Link
AR (1) AR114074A1 (en)
MX (1) MX2018013070A (en)
UY (1) UY38043A (en)
WO (1) WO2019130049A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113521292A (en) * 2020-04-15 2021-10-22 江苏恒瑞医药股份有限公司 Compound preparation of COX-2 inhibitor and tramadol

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1207994B (en) 1986-01-03 1989-06-01 Therapicon Srl WATER SOLUBLE SALTS OF ANTI-INFLAMMATORY AND ANALGESIC ADAPTITY COMPOUNDS, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS.
CN1349423A (en) 1999-03-01 2002-05-15 奥索-麦克尼尔药品公司 Composition comprising tramadol aterial and a selective cox-2 inhibitor drug
ATE320809T1 (en) 1999-11-29 2006-04-15 Merck Frosst Canada Inc POLYMORPHOUS, AMORPHOUS AND HYDRATED FORMS OF 5-CHLORINE-3-(METHANSULFONYLPHENYL)-6'-METHYL-2, 3')BIPYRIDINYL
PH12001001175B1 (en) 2000-05-26 2006-08-10 Merck Sharp & Dohme 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl- (2,3')bipyridinyl in pure crystalline form and process for synthesis
NZ535500A (en) 2002-02-19 2006-09-29 Adcock Ingram Ltd Pharmaceutical combinations of COX-2 inhibitors i.e. meloxicam, opiates i.e. codeine and centrally acting cox inhibitors i.e. paracetamol
WO2005085199A1 (en) 2004-01-14 2005-09-15 Cadila Healthcare Limited Novel polymorphs of etoricoxib
JP5068167B2 (en) 2005-06-10 2012-11-07 中外製薬株式会社 Stabilizer for protein preparation containing meglumine and use thereof
AU2005338461A1 (en) 2005-11-22 2007-05-31 Teva Pharmaceutical Industries Ltd. Pharmaceutical compositions of telmisartan
BRPI0700133A (en) 2007-01-29 2008-09-16 Incrementha P D & I Pesquisa D pharmaceutical composition comprising tramadol and ketoprofen in combination
US20080026054A1 (en) 2007-04-27 2008-01-31 Nectid Inc. Novel anelgesic combination
KR101972299B1 (en) 2007-11-23 2019-08-16 그뤼넨탈 게엠베하 Tapentadol compositions
EP2177215A1 (en) 2008-10-17 2010-04-21 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of tramadol and NSAIDs
CZ2008740A3 (en) 2008-11-24 2010-01-06 Zentiva, A.S. Solid pharmaceutical composition with atorvastatin and telmisartan active ingredients
EP2281558A1 (en) 2009-08-06 2011-02-09 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical compounds of O-Desmethyl-Tramadol and COX-inhibitors
KR101471585B1 (en) 2009-10-16 2014-12-10 라보라토리오스 델 드라. 에스테브.에스.에이. Co-crystals of Tramadol and Coxibs
WO2012004677A1 (en) 2010-07-05 2012-01-12 Actavis Group Ptc Ehf Solid state forms of etoricoxib salts
EP2601952A1 (en) 2011-12-07 2013-06-12 Zentiva, k.s. Novel pharmaceutically acceptable salts and cocrystals of 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyl and their therapeutic uses
WO2014033526A1 (en) 2012-08-27 2014-03-06 Cadila Healthcare Limited Pharmaceutical compositions of etoricoxib
EP3179987A1 (en) 2014-07-31 2017-06-21 KRKA, d.d., Novo mesto Pharmaceutical composition of etoricoxib
WO2016036588A1 (en) 2014-09-03 2016-03-10 Merck Sharp & Dohme Corp. Pharmaceutical suspensions containing etoricoxib
CN104586799A (en) 2015-01-07 2015-05-06 万全万特制药江苏有限公司 Etoricoxib dispersible tablets and preparation method thereof
CN105343002B (en) 2015-11-27 2019-07-26 济南康和医药科技有限公司 A kind of Etoricoxib oral microemulsion preparation and preparation method thereof
EP3238714A1 (en) * 2016-04-28 2017-11-01 Sanovel Ilac Sanayi ve Ticaret A.S. Extended release formulations of flurbiprofen and tramadol
MX2016006464A (en) 2016-05-18 2017-11-17 Laboratorios Liomont S A De C V Pharmaceutical composition of a combination of tramadol-etoricoxib hydrochloride for the treatment of pain.

Also Published As

Publication number Publication date
WO2019130049A1 (en) 2019-07-04
UY38043A (en) 2019-07-31
AR114074A1 (en) 2020-07-15

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