MX2018006790A - Composiciones que contienen decitabina, 5azacitidina y etrahidrouridina y sus usos. - Google Patents
Composiciones que contienen decitabina, 5azacitidina y etrahidrouridina y sus usos.Info
- Publication number
- MX2018006790A MX2018006790A MX2018006790A MX2018006790A MX2018006790A MX 2018006790 A MX2018006790 A MX 2018006790A MX 2018006790 A MX2018006790 A MX 2018006790A MX 2018006790 A MX2018006790 A MX 2018006790A MX 2018006790 A MX2018006790 A MX 2018006790A
- Authority
- MX
- Mexico
- Prior art keywords
- tetrahydrouridine
- compositions containing
- decitabine
- containing decitabine
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen composiciones que comprenden decitabina y tetrahidrouridina o 5-azacitidina y tetrahidrouridina para el tratamiento del cancer. Las composiciones en forma de pildora se administran a un sujeto humano en secuencia o de manera alternada en funcion de la medicion de biomarcadores predictivos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562262839P | 2015-12-03 | 2015-12-03 | |
US201662429292P | 2016-12-02 | 2016-12-02 | |
PCT/US2016/064935 WO2017096357A1 (en) | 2015-12-03 | 2016-12-05 | Compositions containing decitabine, 5azacytidine and tetrahydrouridine and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018006790A true MX2018006790A (es) | 2019-05-02 |
Family
ID=58798100
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021007569A MX2021007569A (es) | 2015-12-03 | 2016-12-05 | Composiciones que contienen decitabina, 5azacitidina y tetrahidrouridina y sus usos. |
MX2018006790A MX2018006790A (es) | 2015-12-03 | 2016-12-05 | Composiciones que contienen decitabina, 5azacitidina y etrahidrouridina y sus usos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021007569A MX2021007569A (es) | 2015-12-03 | 2016-12-05 | Composiciones que contienen decitabina, 5azacitidina y tetrahidrouridina y sus usos. |
Country Status (9)
Country | Link |
---|---|
US (3) | US11376270B2 (es) |
EP (2) | EP3383406B1 (es) |
JP (2) | JP7194021B2 (es) |
CN (1) | CN109789155A (es) |
BR (1) | BR112018011324A2 (es) |
CA (1) | CA3007357C (es) |
DK (1) | DK3383406T3 (es) |
MX (2) | MX2021007569A (es) |
WO (1) | WO2017096357A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20220226355A1 (en) * | 2019-05-24 | 2022-07-21 | The Cleveland Clinic Foundation | Timed alternate administration of decitabine and 5-azacytidine for cancer treatment |
US20210077492A1 (en) * | 2019-09-17 | 2021-03-18 | The Trustees Of Indiana University | Methods and compositions of treating pancreatic cancer |
WO2021211890A1 (en) * | 2020-04-16 | 2021-10-21 | Adimabio Llc | Compositions comprising 2'-deoxycytidine analogs and use thereof for the treatment of sickle cell disease, thalassemia, and cancers |
CA3236051A1 (en) | 2021-10-19 | 2023-04-27 | Akirabio, Inc. | Compositions comprising 2'-deoxycytidine analogs and use thereof for the treatment of sickle cell disease, thalassemia, and cancers |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5760208A (en) | 1996-08-14 | 1998-06-02 | The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Process to prepare pyrimidine nucleosides |
ATE339960T1 (de) | 1999-03-01 | 2006-10-15 | Halogenetics Inc | Verwendung von zusammensetzungen enthaltend cldc als strahlungssensibilisatoren in der behandlung von neoplastischen erkrankungen |
US6861513B2 (en) | 2000-01-12 | 2005-03-01 | Schering Corporation | Everninomicin biosynthetic genes |
US6982253B2 (en) | 2002-06-05 | 2006-01-03 | Supergen, Inc. | Liquid formulation of decitabine and use of the same |
US20050056280A1 (en) | 2002-12-31 | 2005-03-17 | Nektar Therapeutics | Receptacle for an aerosolizable pharmaceutical formulation |
WO2005115410A2 (en) | 2004-05-06 | 2005-12-08 | University Of Rochester | Context dependent inhibitors of cytidine deaminases and uses thereof |
US20060069060A1 (en) * | 2004-09-27 | 2006-03-30 | Sanjeev Redkar | Salts of decitabine |
US20060063735A1 (en) | 2004-09-17 | 2006-03-23 | Supergen, Inc. | Salts of 5-azacytidine |
US20060128653A1 (en) | 2004-12-10 | 2006-06-15 | Chunlin Tang | Pharmaceutical formulation of decitabine |
US7250416B2 (en) | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
MX2008001709A (es) | 2005-08-01 | 2008-11-26 | Nupotential Inc | Produccion de celulas reprogramadas con potencial restablecido. |
MX2010003261A (es) | 2007-09-26 | 2010-08-18 | Sinai School Medicine | Analogos de azacitidina y usos de los mismos. |
EP2050757A1 (en) * | 2007-10-10 | 2009-04-22 | Cilag AG | Method of producing 2' -deoxy-5-azacytidine (Decitabine) |
JO2778B1 (en) | 2007-10-16 | 2014-03-15 | ايساي انك | Certain vehicles, installations and methods |
LT3782612T (lt) | 2008-05-15 | 2023-12-27 | Celgene Corporation | Geriamosios citidino analogų kompozicijos ir jų naudojimo būdai |
US9265785B2 (en) * | 2008-12-22 | 2016-02-23 | The Board Of Trustees Of The University Of Illinois | Compositions comprising decitabine and tetrahydrouridine and uses thereof |
US9259469B2 (en) | 2008-12-22 | 2016-02-16 | The Board Of Trustees Of The University Of Illinois | Compositions comprising decitabine and tetrahydrouridine and uses thereof |
JP6063628B2 (ja) | 2009-02-10 | 2017-01-18 | セルジーン インターナショナル サルル | 5−アザシチジンを用いる、非小細胞肺癌の治療方法 |
US8609631B2 (en) | 2009-04-06 | 2013-12-17 | Eisai Inc. | Compositions and methods for treating cancer |
WO2010118010A1 (en) | 2009-04-06 | 2010-10-14 | Eisai Inc. | Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer |
WO2010118013A1 (en) | 2009-04-06 | 2010-10-14 | Eisai Inc. | Combination of cytidine-based antineoplastic drugs with cytidine deaminase inhibitor and use thereof in the treatment of cancer |
CN102485232A (zh) * | 2010-12-06 | 2012-06-06 | 苏州科耐尔医药科技有限公司 | 一种含地西他滨的药物组合物 |
MX2013006020A (es) * | 2011-01-31 | 2013-10-01 | Celgene Corp | Composicion farmaceutica de analogos de citidina y metodos para su uso. |
US8426143B2 (en) * | 2011-05-24 | 2013-04-23 | Saladax Biomedical Inc. | Gemcitabine immunoassay |
US9476099B2 (en) | 2012-08-10 | 2016-10-25 | Trustees Of Dartmouth College | Method for determining sensitivity to decitabine treatment |
US20140100182A1 (en) | 2012-10-05 | 2014-04-10 | The Cleveland Clinic Foundation | Nanogel-Mediated Drug Delivery |
WO2014143051A1 (en) | 2013-03-15 | 2014-09-18 | Richard Daifuku | Fluorinated pyrimidine analogs and methods of use thereof |
WO2017158396A1 (en) | 2016-03-16 | 2017-09-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cytidine deaminase inhibitors for the treatment of pancreatic cancer |
-
2016
- 2016-12-05 DK DK16871704.9T patent/DK3383406T3/da active
- 2016-12-05 MX MX2021007569A patent/MX2021007569A/es unknown
- 2016-12-05 US US15/780,796 patent/US11376270B2/en active Active
- 2016-12-05 WO PCT/US2016/064935 patent/WO2017096357A1/en active Application Filing
- 2016-12-05 EP EP16871704.9A patent/EP3383406B1/en active Active
- 2016-12-05 MX MX2018006790A patent/MX2018006790A/es unknown
- 2016-12-05 EP EP21203432.6A patent/EP3960182A1/en active Pending
- 2016-12-05 CN CN201680080861.2A patent/CN109789155A/zh active Pending
- 2016-12-05 CA CA3007357A patent/CA3007357C/en active Active
- 2016-12-05 BR BR112018011324A patent/BR112018011324A2/pt not_active Application Discontinuation
- 2016-12-05 JP JP2018549129A patent/JP7194021B2/ja active Active
-
2022
- 2022-01-27 US US17/586,387 patent/US11779591B2/en active Active
- 2022-09-13 JP JP2022145598A patent/JP2022184941A/ja active Pending
-
2023
- 2023-09-01 US US18/459,683 patent/US20240165142A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20220152075A1 (en) | 2022-05-19 |
JP2018538370A (ja) | 2018-12-27 |
JP7194021B2 (ja) | 2022-12-21 |
JP2022184941A (ja) | 2022-12-13 |
MX2021007569A (es) | 2022-06-09 |
WO2017096357A1 (en) | 2017-06-08 |
CA3007357A1 (en) | 2017-06-08 |
US11779591B2 (en) | 2023-10-10 |
CN109789155A (zh) | 2019-05-21 |
US20240165142A1 (en) | 2024-05-23 |
EP3383406A4 (en) | 2019-08-21 |
EP3960182A1 (en) | 2022-03-02 |
EP3383406B1 (en) | 2021-10-20 |
US11376270B2 (en) | 2022-07-05 |
CA3007357C (en) | 2023-12-05 |
BR112018011324A2 (pt) | 2018-12-04 |
US20200246368A1 (en) | 2020-08-06 |
EP3383406A1 (en) | 2018-10-10 |
DK3383406T3 (da) | 2022-01-10 |
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