MX2018001042A - Concentrado que contiene alprostadil. - Google Patents

Concentrado que contiene alprostadil.

Info

Publication number
MX2018001042A
MX2018001042A MX2018001042A MX2018001042A MX2018001042A MX 2018001042 A MX2018001042 A MX 2018001042A MX 2018001042 A MX2018001042 A MX 2018001042A MX 2018001042 A MX2018001042 A MX 2018001042A MX 2018001042 A MX2018001042 A MX 2018001042A
Authority
MX
Mexico
Prior art keywords
solvent mixture
acid
active ingredient
concentrate containing
containing alprostadil
Prior art date
Application number
MX2018001042A
Other languages
English (en)
Inventor
HÄUSLER Franz
Hesse Ernst
Hansbauer Bernhard
Original Assignee
Gebro Holding Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gebro Holding Gmbh filed Critical Gebro Holding Gmbh
Publication of MX2018001042A publication Critical patent/MX2018001042A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invención se refiere a una composición farmacéutica líquida en forma de un concentrado para la preparación de una solución para infusión, que contiene alprostadil (prostaglandina E1) como principio activo, disuelto en una mezcla de disolventes de al menos un disolvente orgánico farmacéuticamente aceptable y agua, y se caracteriza porque la proporción de agua total en la mezcla de disolventes se encuentra en el intervalo del 8 al 85 % en peso de H2O, referido a la cantidad total de la mezcla de disolventes, y porque al menos un ácido o una sustancia que actúa de ácido o de donante de protones está contenida como estabilizador para el principio activo.
MX2018001042A 2015-07-27 2016-07-25 Concentrado que contiene alprostadil. MX2018001042A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA50666/2015A AT518009A1 (de) 2015-07-27 2015-07-27 Konzentrat enthaltend Alprostadil
PCT/AT2016/060020 WO2017015692A1 (de) 2015-07-27 2016-07-25 Konzentrat enthaltend alprostadil

Publications (1)

Publication Number Publication Date
MX2018001042A true MX2018001042A (es) 2018-06-07

Family

ID=56852017

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018001042A MX2018001042A (es) 2015-07-27 2016-07-25 Concentrado que contiene alprostadil.

Country Status (8)

Country Link
EP (1) EP3328358B1 (es)
AR (1) AR105504A1 (es)
AT (1) AT518009A1 (es)
BR (1) BR112018001637A2 (es)
CO (1) CO2018000525A2 (es)
MX (1) MX2018001042A (es)
PE (1) PE20180466A1 (es)
WO (1) WO2017015692A1 (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0669966B2 (ja) * 1989-07-05 1994-09-07 株式会社ミドリ十字 血管造影補助剤
DE69421936T2 (de) * 1993-10-27 2000-06-29 Upjohn Co Stabilisiertes prostaglandin e1
DE4342232A1 (de) * 1993-12-10 1995-06-14 Hexal Pharma Gmbh Feste Zubereitung für therapeutische Zwecke mit einem Gehalt an Prostaglandin E1
CN102048687A (zh) * 2009-11-06 2011-05-11 华北制药集团制剂有限公司 一种前列地尔注射液的制备方法
CN103110579B (zh) * 2013-02-20 2014-12-10 北京德立福瑞医药科技有限公司 前列地尔注射剂

Also Published As

Publication number Publication date
EP3328358B1 (de) 2022-11-23
PE20180466A1 (es) 2018-03-06
CO2018000525A2 (es) 2018-04-10
WO2017015692A1 (de) 2017-02-02
BR112018001637A2 (pt) 2018-09-18
AR105504A1 (es) 2017-10-11
EP3328358A1 (de) 2018-06-06
AT518009A1 (de) 2017-06-15

Similar Documents

Publication Publication Date Title
MX2016015179A (es) Una formulación líquida que comprende nicotina para administracion en aerosol.
SG10201806300VA (en) Liquid pharmaceutical composition
PH12015502542A1 (en) Stabilized pemetrexed formulation
BR112015000229A2 (pt) formulações aquosas estáveis de etanercept
WO2012148247A3 (ko) 올레아놀린산 아세테이트를 유효성분으로 포함하는 tlr 및 il-6 매개성 질환예방 또는 치료용 약학적 조성물
EA201791166A1 (ru) Препараты с контролируемым высвобождением
MX2021009377A (es) Formulaciones de espuma y aparatos para su suministro.
CR20200291A (es) Composiciones y métodos para el tratamiento de enfermedades metabólicas
MX2019003520A (es) Mezclas y formulacions que comprenden una sal de alquil amonio de acido etilendiaminotetraacetico (edta).
PH12016502544A1 (en) Pharmaceutical preparation containing entecavir as active ingredient, and preparation method therefor
MX353975B (es) Formulaciones estables no corrosivas para inhaladores presurizados de dosis medida.
MX2018001042A (es) Concentrado que contiene alprostadil.
MX2016009458A (es) Solucion alcoholica estable de alprostadilo.
MX2018001041A (es) Concentrado que contiene alprostadil.
BR112015023750A2 (pt) composição agricolamente ativa concentrada; método de preparação da composição pronta para uso; composição pronta para uso; e método para o tratamento de uma planta
UY37426A (es) Método para producir una composición farmacéuticamente estable presentada como una solución acuosa
JO3689B1 (ar) صيغ من الباراسيتامول قابلة للحقن
PL425725A1 (pl) Produkt leczniczy zawierający wodny roztwór metyzoprynolu o ulepszonej trwałości
EA201790750A1 (ru) Назальная лекарственная композиция, содержащая морскую воду в качестве вспомогательного вещества, улучшающего стабильность препарата
TH170460A (th) "องค์ประกอบเภสัชภัณฑ์สำหรับการให้ทางปากซึ่งประกอบรวมด้วยแทกเซน"
TH182887B (th) องค์ประกอบเภสัชภัณฑ์ที่มีเสถียรภาพและวิธีการสำหรับการจัดเตรียมสิ่งเดียวกันนี้
UA101467U (uk) Спосіб збільшення приросту живої маси поросят у підсисний період
IN2014MU01178A (es)
EA201500090A1 (ru) Фармацевтическая композиция, содержащая силденафила цитрат, и способ ее приготовления
EA201500198A1 (ru) Стабильная фармацевтическая композиция в форме назального спрея, содержащая кеторолак