MX2017008058A - Formulaciones farmaceuticas de inhibidores de la cinasa relacionada con tropomiosina (trk). - Google Patents

Formulaciones farmaceuticas de inhibidores de la cinasa relacionada con tropomiosina (trk).

Info

Publication number
MX2017008058A
MX2017008058A MX2017008058A MX2017008058A MX2017008058A MX 2017008058 A MX2017008058 A MX 2017008058A MX 2017008058 A MX2017008058 A MX 2017008058A MX 2017008058 A MX2017008058 A MX 2017008058A MX 2017008058 A MX2017008058 A MX 2017008058A
Authority
MX
Mexico
Prior art keywords
pharmaceutical formulations
trk
related kinase
inhibitors
tropomyosin
Prior art date
Application number
MX2017008058A
Other languages
English (en)
Inventor
Yang Donglai
lieberman Harvey
Michael Philbrook C
HO Chris
Santos Michael
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55080206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017008058(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of MX2017008058A publication Critical patent/MX2017008058A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

En la presente se describen formulaciones farmacéuticas con un inhibidor de cinasa relacionada con tropomiosina ("inhibidor de Trk"). Las formulaciones farmacéuticas comprenden 3-(3-metoxi-4-((4- metoxibencil)oxi)bencil)-6-(1-metil-1H-pirazol- 4-i1)-3H-imidazo[4 ,5- b]piridin-2-amina en formulaciones de suspensión microcristalina en su forma monohidratada, que muestra características mejoradas frente a la forma anhidra y en formulaciones de liberación prolongada. Las formulaciones farmacéuticas de liberación prolongada comprenden microesferas cargadas con 3-(3-metoxi-4-((4-metoxibencipoxi)bencil)-6- (1-metil-1H-pirazol-4-i1)-3H-imidazo[4,5-11piridin-2-amina.
MX2017008058A 2014-12-18 2015-12-17 Formulaciones farmaceuticas de inhibidores de la cinasa relacionada con tropomiosina (trk). MX2017008058A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462093801P 2014-12-18 2014-12-18
PCT/US2015/066396 WO2016100677A2 (en) 2014-12-18 2015-12-17 Pharmaceutical formulations of tropomyosin related kinase (trk) inhibitors

Publications (1)

Publication Number Publication Date
MX2017008058A true MX2017008058A (es) 2017-09-28

Family

ID=55080206

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017008058A MX2017008058A (es) 2014-12-18 2015-12-17 Formulaciones farmaceuticas de inhibidores de la cinasa relacionada con tropomiosina (trk).
MX2020013015A MX2020013015A (es) 2014-12-18 2017-06-16 Formulaciones farmaceuticas de inhibidores de cinasa relacionada con tropomiosina (trk).

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020013015A MX2020013015A (es) 2014-12-18 2017-06-16 Formulaciones farmaceuticas de inhibidores de cinasa relacionada con tropomiosina (trk).

Country Status (22)

Country Link
US (3) US10219998B2 (es)
EP (1) EP3233057A2 (es)
JP (1) JP6606183B2 (es)
KR (1) KR102561692B1 (es)
CN (2) CN107231803B (es)
AR (1) AR103176A1 (es)
AU (1) AU2015364557C1 (es)
BR (1) BR112017012566B1 (es)
CA (1) CA2970938C (es)
CL (1) CL2017001543A1 (es)
CO (1) CO2017007118A2 (es)
EA (1) EA201791336A1 (es)
IL (1) IL252901B (es)
MA (1) MA40698A3 (es)
MX (2) MX2017008058A (es)
MY (1) MY195799A (es)
NZ (1) NZ733825A (es)
PH (1) PH12017501121B1 (es)
SG (1) SG11201704872RA (es)
TN (1) TN2017000234A1 (es)
TW (2) TWI696621B (es)
WO (1) WO2016100677A2 (es)

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CN110156813B (zh) * 2018-02-13 2023-07-25 北京诺诚健华医药科技有限公司 作为trk抑制剂的杂环化合物
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EP4180428A1 (en) 2021-11-12 2023-05-17 Genzyme Corporation Crystalline imidazo[4,5-b]pyridine compound, pharmaceutical compositions, and their use in treating medical conditions
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BR112017012566A2 (pt) 2018-01-02
CO2017007118A2 (es) 2017-08-18
IL252901B (en) 2020-10-29
JP6606183B2 (ja) 2019-11-13
MY195799A (en) 2023-02-21
KR20170096160A (ko) 2017-08-23
AU2015364557C1 (en) 2021-11-18
CN110950862B (zh) 2024-01-05
TW202104225A (zh) 2021-02-01
US20200048222A1 (en) 2020-02-13
WO2016100677A3 (en) 2016-08-11
PH12017501121A1 (en) 2017-11-27
TWI780438B (zh) 2022-10-11
CN107231803A (zh) 2017-10-03
EP3233057A2 (en) 2017-10-25
US11110055B2 (en) 2021-09-07
AR103176A1 (es) 2017-04-19
CA2970938A1 (en) 2016-06-23
NZ733825A (en) 2022-02-25
CA2970938C (en) 2023-04-18
MA40698A3 (fr) 2020-01-31
TWI696621B (zh) 2020-06-21
JP2018503611A (ja) 2018-02-08
IL252901A0 (en) 2017-08-31
US20180000728A1 (en) 2018-01-04
US20220110861A1 (en) 2022-04-14
SG11201704872RA (en) 2017-07-28
AU2015364557B2 (en) 2021-04-29
CN110950862A (zh) 2020-04-03
US10219998B2 (en) 2019-03-05
CL2017001543A1 (es) 2018-03-16
PH12017501121B1 (en) 2017-11-27
MX2020013015A (es) 2021-02-22
WO2016100677A2 (en) 2016-06-23
TN2017000234A1 (en) 2018-10-19
KR102561692B1 (ko) 2023-07-28
US11793749B2 (en) 2023-10-24
AU2015364557A1 (en) 2017-08-03
MA40698A2 (fr) 2018-10-31
BR112017012566B1 (pt) 2024-01-30
EA201791336A1 (ru) 2017-10-31
CN107231803B (zh) 2019-12-03
TW201639837A (zh) 2016-11-16

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