MX2017007643A - Composicion farmaceutica que comprende compuesto biciclico de amida heterociclica aromatica que contiene nitrogeno como ingrediente activo. - Google Patents
Composicion farmaceutica que comprende compuesto biciclico de amida heterociclica aromatica que contiene nitrogeno como ingrediente activo.Info
- Publication number
- MX2017007643A MX2017007643A MX2017007643A MX2017007643A MX2017007643A MX 2017007643 A MX2017007643 A MX 2017007643A MX 2017007643 A MX2017007643 A MX 2017007643A MX 2017007643 A MX2017007643 A MX 2017007643A MX 2017007643 A MX2017007643 A MX 2017007643A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical composition
- aromatic heterocyclic
- containing aromatic
- active component
- heterocyclic amide
- Prior art date
Links
- -1 bicyclic nitrogen-containing aromatic heterocyclic amide compound Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000034578 Multiple myelomas Diseases 0.000 abstract 2
- 206010035226 Plasma cell myeloma Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 230000002438 mitochondrial effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 230000009036 growth inhibition Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Problema. Se proporciona una composición farmacéutica para el tratamiento de mieloma múltiple. Medios para Solución. Los inventores de la presente invención efectuaron exámenes sobre un compuesto que tiene un efecto de inhibir el Complejo I de la mitocondria, y confirmaron que un compuesto bicíclico de amida heterocíclica aromática que contiene nitrógeno de la presente invención tiene el efecto de inhibir el Complejo I de la mitocondria y que este compuesto muestra el efecto de inhibir el crecimiento de mieloma múltiple, y por lo tanto terminaron la presente invención.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014249350 | 2014-12-09 | ||
| PCT/JP2015/084341 WO2016093203A1 (ja) | 2014-12-09 | 2015-12-08 | 二環式含窒素芳香族ヘテロ環アミド化合物を有効成分とする医薬組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017007643A true MX2017007643A (es) | 2017-10-11 |
Family
ID=56107386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017007643A MX2017007643A (es) | 2014-12-09 | 2015-12-08 | Composicion farmaceutica que comprende compuesto biciclico de amida heterociclica aromatica que contiene nitrogeno como ingrediente activo. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20170360780A1 (es) |
| EP (1) | EP3231425A1 (es) |
| JP (1) | JPWO2016093203A1 (es) |
| KR (1) | KR20170088882A (es) |
| CN (1) | CN106999488A (es) |
| AU (1) | AU2015362516A1 (es) |
| BR (1) | BR112017012379A2 (es) |
| CA (1) | CA2970232A1 (es) |
| IL (1) | IL252663A0 (es) |
| MA (1) | MA41158A (es) |
| MX (1) | MX2017007643A (es) |
| RU (1) | RU2017120173A (es) |
| SG (1) | SG11201704593QA (es) |
| TW (1) | TW201636021A (es) |
| WO (1) | WO2016093203A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117045800A (zh) * | 2022-05-06 | 2023-11-14 | 上海科技大学 | mTOR抑制剂增强靶向蛋白降解药物功效的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7410998B2 (en) * | 2000-09-06 | 2008-08-12 | The Scripps Research Institute | Inhibitors of NADH:ubiquinone oxidoreductase |
| EP3009424B1 (en) * | 2013-06-10 | 2017-12-20 | Astellas Pharma Inc. | Bicyclic nitrogen-containing aromatic heterocyclic amide compound |
-
2015
- 2015-12-07 MA MA041158A patent/MA41158A/fr unknown
- 2015-12-08 US US15/534,355 patent/US20170360780A1/en not_active Abandoned
- 2015-12-08 AU AU2015362516A patent/AU2015362516A1/en not_active Abandoned
- 2015-12-08 MX MX2017007643A patent/MX2017007643A/es unknown
- 2015-12-08 CN CN201580067074.XA patent/CN106999488A/zh active Pending
- 2015-12-08 WO PCT/JP2015/084341 patent/WO2016093203A1/ja active Application Filing
- 2015-12-08 TW TW104141107A patent/TW201636021A/zh unknown
- 2015-12-08 EP EP15867918.3A patent/EP3231425A1/en not_active Withdrawn
- 2015-12-08 JP JP2016563670A patent/JPWO2016093203A1/ja active Pending
- 2015-12-08 BR BR112017012379-7A patent/BR112017012379A2/pt not_active Application Discontinuation
- 2015-12-08 CA CA2970232A patent/CA2970232A1/en not_active Abandoned
- 2015-12-08 SG SG11201704593QA patent/SG11201704593QA/en unknown
- 2015-12-08 RU RU2017120173A patent/RU2017120173A/ru not_active Application Discontinuation
- 2015-12-08 KR KR1020177015806A patent/KR20170088882A/ko unknown
-
2017
- 2017-06-05 IL IL252663A patent/IL252663A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2970232A1 (en) | 2016-06-16 |
| EP3231425A1 (en) | 2017-10-18 |
| AU2015362516A1 (en) | 2017-06-29 |
| RU2017120173A (ru) | 2019-01-11 |
| IL252663A0 (en) | 2017-08-31 |
| TW201636021A (zh) | 2016-10-16 |
| WO2016093203A1 (ja) | 2016-06-16 |
| JPWO2016093203A1 (ja) | 2017-09-14 |
| BR112017012379A2 (pt) | 2018-04-24 |
| MA41158A (fr) | 2017-10-17 |
| US20170360780A1 (en) | 2017-12-21 |
| KR20170088882A (ko) | 2017-08-02 |
| CN106999488A (zh) | 2017-08-01 |
| SG11201704593QA (en) | 2017-07-28 |
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