MX2017007249A - Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof. - Google Patents

Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof.

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Publication number
MX2017007249A
MX2017007249A MX2017007249A MX2017007249A MX2017007249A MX 2017007249 A MX2017007249 A MX 2017007249A MX 2017007249 A MX2017007249 A MX 2017007249A MX 2017007249 A MX2017007249 A MX 2017007249A MX 2017007249 A MX2017007249 A MX 2017007249A
Authority
MX
Mexico
Prior art keywords
receptor
chimeric antigen
antigen receptors
fcrl5
cars
Prior art date
Application number
MX2017007249A
Other languages
Spanish (es)
Inventor
Liu Cheng
Renier J Brentjens
L Smith Eric
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of MX2017007249A publication Critical patent/MX2017007249A/en

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
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    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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Abstract

The presently disclosed subject matter provides for methods and compositions for treating a neoplasia (e.g., multiple myeloma). It relates to chimeric antigen receptors (CARs) that specifically target Fc Receptor-like 5 (FcRL5), e.g., domain 9 of FcRL5, and immunoresponsive cells comprising such CARs. The presently disclosed FcRL5-targeted CARs have enhanced immune-activating properties, including anti-tumor activity.
MX2017007249A 2014-12-05 2015-12-04 Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof. MX2017007249A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462088164P 2014-12-05 2014-12-05
PCT/US2015/064134 WO2016090337A1 (en) 2014-12-05 2015-12-04 Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof

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MX2017007249A true MX2017007249A (en) 2018-01-25

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MX2017007249A MX2017007249A (en) 2014-12-05 2015-12-04 Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof.

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US (2) US11059891B2 (en)
EP (1) EP3227436A4 (en)
JP (3) JP7174522B2 (en)
KR (1) KR20170108946A (en)
CN (2) CN109072199B (en)
AU (2) AU2015357543B2 (en)
BR (1) BR112017011936A2 (en)
CA (1) CA2974434A1 (en)
IL (2) IL252655B (en)
MX (1) MX2017007249A (en)
MY (1) MY192062A (en)
NZ (1) NZ732570A (en)
PH (1) PH12017501041A1 (en)
SG (2) SG11201704550XA (en)
WO (1) WO2016090337A1 (en)

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